报告题目：突触上的谷氨酸受体
报告人：石云教授
单位：南京大学模式动物研究所
时间：2017年1月11日，下午1:30
地点：遗传发育所2号楼B109会议室
联系人：刘佳佳
联系电话：64806561
报告人简历
石 云
生理学 博士；神经生物学 教授
专业特长：神经科学和生理学。擅长运用电生理和分子生物学方法研究离子通道及受体的生理和药理活性，以及复杂的神经生理活动。
主要研究方向
中枢神经可塑性；谷氨酸受体和亚单位：结构和功能；新型离子通道
专业经历
2013- 教授，南京大学模式动物研究所
2008-2012 博士后，美国加州大学旧金山分校药理系，师从Roger Nicoll 院士。
1997-2001 助教，南京医科大学
获奖和荣誉
2014 江苏省杰出青年
2014 江苏省双创人才
2007 佐治亚州立大学杰出研究奖
2005-2007 疾病的分子基础基金，佐治亚州
发表论文节选
- Sheng N, Shi YS, Nicoll RA. (2017)The amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking. Proc Natl Acad Sci U S A. (in press)
- He XY, Li YJ, Kalyanaraman C, Qiu LL, Chen C, Xiao Q, Liu WX, Zhang W, Yang JJ, Chen G, Jacobson MP, Shi YS#. (2016) GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors. Proc Natl Acad Sci U S A. Sep 20;113(38):E5645-54. #通讯作者
- Wei M, Zhang J, Jia M, Yang C, Pan Y, Li S, Luo Y, Zheng J, Ji J, Chen J, Hu X, Xiong J, Shi Y, Zhang C.(2016) α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors. Proc Natl Acad Sci U S A. May 10; 113(19):E2695-704.
- Sheng N, Shi YS, Lomash RM, Roche KW, Nicoll RA. (2015) Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1. Elife. pii: e11682
- Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA. (2013) LTP requires an extrasynaptic pool of glutamate receptors independent of subunit type. Nature. 493(7433)，495-500
- Herring B*, Shi Y*, Suh YH, Zheng CY, Schmid SM, Roche KW, Nicoll RA. (2013) Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 77(6),1083-96 *共同第一作者
- Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll RA. (2011) Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: analysis of single-cell GluN2 subunit deletion in vivo. Neuron. 71(6), 1085-1101
- Shi Y, Suh YH, Milstein AD, Isozaki K, Schmid SM, Roche KW, Nicoll RA. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc Natl Acad Sci U S A. 107(37), 16315-16319
- Shi Y, Lu W, Milstein AD, Nicoll RA. (2009) The stoichiometry of AMPA receptors and TARPs varies by neuronal cell types. Neuron. 62(5), 633-40
- Lu W, Shi Y, Jackson A, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA. (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron. 62(2), 254-68
- Shi Y, Chen X, Wu Z, Shi W, Jiang C, Harrison R. (2008) cAMP-dependent protein kinase phosphorylation produces interdomain movements in SUR2B leading to activation of vascular KATP channel. Journal of Biological Chemistry. 283(12), 7523-30
- Shi Y, Cui N, Shi W, Jiang C. (2008) A short motif in Kir6.1 consisting of 4 phosphorylation repeats underlies vascular KATP channel inhibition by protein kinase C. Journal of Biological Chemistry. 283(5), 2488-94
- Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, Rojas A, Ha BT, Jiang C. (2007) PKA phosphorylation on SUR2B subunit underscores vascular KATP channel activation by β-adrenergic receptors. American Journal of Physiology. 293(3), R1205-14
