报告题目：p53 and Tumor Cell Metabolism

报告人：Xiaolu Yang，Professor, Department of Cancer Biology, University of Pennsylvania

报告时间：2010年8月24日上午10：00

地点：中科院遗传发育所一号楼B210

联系人：许执恒 64806581, zhxu@genetics.ac.cn

Selected Publications from Dr. Yang (通信作者）

1.c-FLIPL is a dual function molecule for caspase-8 activation and CD95-mediated apoptosis. EMBOJ.(2002).

2.Interdimer processing mechanism ofprocaspase-8 activation.EMBO J.(2003).

3.cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosaassociatedlymphoid tissue lymphomas.J. Clinical Investigation(2006).

4.Critical role for Daxx in regulating Mdm2. Nature Cell Biology (2006).

5.The paracaspase MALT1 controls caspase-8 activationduring lymphocyte proliferation. Molecular Cell(2008).

6.tRNA binds to cytochrome c andinhibits caspase activation. Molecular Cell (2010).

7.SUMO E3 ligase activity of TRIM proteins. Oncogene (2011).

8.The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.JBC. (2011).

9.Siva1 suppresses epithelial-mesenchymaltransition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. PNAS(2011)

10.p53 regulates biosynthesis throughdirect inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology13: 310-18 (2011).