报告题目：Misregulation of TGF-beta receptor signaling in cancer

　　报 告 人： Dr. Peter ten Dijke,Professor and Head,Section Aging and Signal Transduction,Molecular Cell Biology, Leiden University Medical Center,The Netherlands

　　报告时间：2013年10月22日,星期二,下午3:00

　　报告地点：中科院遗传发育所1号楼210报告厅

　　Transforming growth factor-β (TGF-β) is a secreted homodimeric protein that regulates numerous responses, such as proliferation, differentiation, migration and apoptosis. He is interested in unraveling mechanisms by which TGF-β family members elicit their multifunctional cellular effects and how perturbation in their signal transduction pathways contribute to human diseases. Previous research from his and other laboratories has firmly established the intracellular signaling cascade of TGF-β via serine/threonine kinase receptors and SMAD transcriptional effectors. However, how this pathway is (mis)regulated in cancer and other diseases, remains not well understood. This presentation will discuss some of the aspects of the involvement of TGF-β family members in the metastasis of cancer cells, tumor angiogenesis and high/low bone mass diseases. Professor ten Dijke is one of the leading scientists in the field, having co-authored about 300 research papers and being widely cited. Among many other important contributions, he was one of the first who cloned TGF-β and its receptors as well as Smad7.