Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex
| 作者： |
Dan Xu,Feng Zhang,Yaqing Wang,Yiming Sun,Zhiheng Xu |
| 刊物名称： |
Cell Reports |
| DOI： |
|
| 联系作者： |
|
| 英文联系作者： |
|
| 发表年度： |
2014-01-05 |
| 卷： |
|
| 摘要： |
premature differentiation of neural progenitor cells (NPCs). The defect can be rescued by wild-type human WDR62, but not by the five MCPH-associated WDR62 mutants. We demonstrate that WDR62 acts upstream of JNK signaling in the control of neurogenesis. Depletion of JNK1 and WDR62 incurs very similar defects including abnormal spindle formation and mitotic division of NPCs as well as premature NPC differentiation during cortical development. Thus, our findings indicate that WDR62 is required for proper neurogenesis via JNK1 and provide an insight into the molecular mechanisms underlying MCPH pathogenesis. |
| 参与作者： |
|
