Targeted genome editing in primate embryos
| 作者： |
Xiangyu Guo and Xiao-Jiang Li |
| 刊物名称： |
Cell Research |
| DOI： |
|
| 联系作者： |
|
| 英文联系作者： |
|
| 发布时间： |
2015-06-05 |
| 卷： |
|
| 摘要： |
Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases. |
| 参与作者： |
|
