Targeted genome editing in primate embryos
| 作者： |
Xiangyu Guo and Xiao-Jiang Li |
| 刊物名称： |
Cell Research |
| DOI： |
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| 发表年度： |
2015-06-05 |
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| 摘要： |
Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals. Here we discuss recent findings from primate embryos, with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases. |
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