论文--中国科学院遗传与发育生物学研究所

Membrane Protein MHZ3 Regulates the On-off Switch of Ethylene Signaling in Rice

作者：	Xinkai Li, Yihua Huang, Rui Zhao, Wuqiang Cao, Long Lu, Jiaqi Han, Yang Zhou, Xun Zhang, Wenai Wu, Jianjun Tao, Wei Wei, Wanke Zhang, Shouyi Chen, Biao Ma, He Zhao, Cuicui Yin, Jinsong Zhang
刊物名称：	Nature Communications
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发布时间：	2024-07-18
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摘要：	Ethylene regulates plant growth, development, and stress adaptation. However, the early signaling events following ethylene perception, particularly in the regulation of ethylene receptor/CTRs (CONSTITUTIVE TRIPLE RESPONSE) complex, remains less understood. Here, utilizing the rapid phospho-shift of rice OsCTR2 in response to ethylene as a sensitive readout for signal activation, we revealed that MHZ3, previously identified as a stabilizer of ETHYLENE INSENSITIVE 2 (OsEIN2), is crucial for maintaining OsCTR2 phosphorylation. Genetically, both functional MHZ3 and ethylene receptors prove essential for OsCTR2 phosphorylation. MHZ3 physically interacts with both subfamily I and II ethylene receptors, e.g., OsERS2 and OsETR2 respectively, stabilizing their association with OsCTR2 and thereby maintaining OsCTR2 activity. Ethylene treatment disrupts the interactions within the protein complex MHZ3/receptors/OsCTR2, reducing OsCTR2 phosphorylation and initiating downstream signaling.Our study unveils the dual role of MHZ3 in fine-tuning ethylenesignaling activation, providing insights into the initial stages of the ethylene signaling cascade.
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