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Hepatic Loss of Cers2 Induces Cell Division Defects via Amad2-Mediated Pathway
Mingjun Cao, Shaohua Zhang, Sin Man Lam, Guanghou Shui
Clinical and Translational Medicine
Abstract
Cytokinesis failure is the primary cause of hepatocytepolyploidization. However, there are few studies onceramide synthase and polyploidy. Ceramide synthases(CerS) have six isoforms (CerS1-CerS6), each of whichcan synthesize ceramides with different acyl chain lengths(C14:0-C30:0) and possess tissue-specific distribution. Ceramide synthase 2 (CerS2) preferentially synthesizesceramides with longer acyl chains of C22 and C24. In human hepatocellular carcinoma (HCC), CerS2 geneexpression was lower compared with the normal liver. We found that the deletion of CerS2 led to abnormal hep-atic chromosome polyploidy and substantial steatosis andhepatic carcinoma in 15-month-old mice. Further stud-ies demonstrated that CerS2 plays a critical role in main-taining hepatic chromosome polyploidization via Mad2expression during cell division.
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| 论文编号: |
DOI:10.1002/ctm2.712 |
| 论文题目: |
Hepatic Loss of Cers2 Induces Cell Division Defects via Amad2-Mediated Pathway |
| 英文论文题目: |
Hepatic Loss of Cers2 Induces Cell Division Defects via Amad2-Mediated Pathway |
| 第一作者: |
Mingjun Cao, Shaohua Zhang, Sin Man Lam, Guanghou Shui |
| 英文第一作者: |
Mingjun Cao, Shaohua Zhang, Sin Man Lam, Guanghou Shui |
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2022-01-30 |
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| 摘要: |
Cytokinesis failure is the primary cause of hepatocytepolyploidization. However, there are few studies onceramide synthase and polyploidy. Ceramide synthases(CerS) have six isoforms (CerS1-CerS6), each of whichcan synthesize ceramides with different acyl chain lengths(C14:0-C30:0) and possess tissue-specific distribution. Ceramide synthase 2 (CerS2) preferentially synthesizesceramides with longer acyl chains of C22 and C24. In human hepatocellular carcinoma (HCC), CerS2 geneexpression was lower compared with the normal liver. We found that the deletion of CerS2 led to abnormal hep-atic chromosome polyploidy and substantial steatosis andhepatic carcinoma in 15-month-old mice. Further stud-ies demonstrated that CerS2 plays a critical role in main-taining hepatic chromosome polyploidization via Mad2expression during cell division. |
| 英文摘要: |
Cytokinesis failure is the primary cause of hepatocytepolyploidization. However, there are few studies onceramide synthase and polyploidy. Ceramide synthases(CerS) have six isoforms (CerS1-CerS6), each of whichcan synthesize ceramides with different acyl chain lengths(C14:0-C30:0) and possess tissue-specific distribution. Ceramide synthase 2 (CerS2) preferentially synthesizesceramides with longer acyl chains of C22 and C24. In human hepatocellular carcinoma (HCC), CerS2 geneexpression was lower compared with the normal liver. We found that the deletion of CerS2 led to abnormal hep-atic chromosome polyploidy and substantial steatosis andhepatic carcinoma in 15-month-old mice. Further stud-ies demonstrated that CerS2 plays a critical role in main-taining hepatic chromosome polyploidization via Mad2expression during cell division. |
| 刊物名称: |
Clinical and Translational Medicine |
| 英文刊物名称: |
Clinical and Translational Medicine |
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| 其它备注: |
Mingjun Cao, Shaohua Zhang, Sin Man Lam, Guanghou Shui. Hepatic Loss of Cers2 Induces Cell Division Defects via Amad2-Mediated Pathway. Clinical and Translational Medicine. DOI:10.1002/ctm2.712 |
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