--中国科学院遗传与发育生物学研究所

姓　　名：	马润林
职　　称：	研究员
职　　务：
电话/传真：	86-10-64806599
电子邮件：	rlma@genetics.ac.cn
实验室主页：
研究方向：	人类及动物功能基因组学

简历介绍：

马润林，博士，研究员，博士生导师

马润林实验室研究方向为免疫功能基因组学与免疫遗传学。主要研究人类免疫与自身免疫性疾病的动物模型与组胺过敏相关基因的功能；反刍类动物免疫基因组MHC结构与功能的关系以及MHC比较进化；肺器官早期发育与免疫；侵染性及自身免疫性疾病的致病致癌分子机理。

创新研究课题组长马润林博士, 研究员。1982 年获石河子大学学士学位，1987年获美国明尼苏达大学硕士学位，1991年获堪萨斯州立大学博士学位，1992-1996在伊利诺依大学做分子遗传学博士后研究，1997起任伊利诺依大学（UIUC）研究助理教授，1999起任辛辛拉提大学医学院研究助理教授，2001年获得国家杰出青年基金，2004入选新世纪首批“百千万”人才国家级人选， 2009成为国务院颁发的政府特殊津贴专家。先后在国际英文专业学术刊物上发表 50余篇SCI研究论文。

马润林博士还是新西兰梅西大学荣誉教授。

研究领域：

当前研究课题方向：

1. 绵羊免疫基因组MHC的精细结构与反刍类动物比较进化研究。

2. 肺器官发育及Rcn3敲除导致小鼠肺功能失败的分子机理。

3. 病毒基因对细胞有丝分裂的调控机理与癌症干细胞。

热诚欢迎热爱生命科学、有志向、有能力、且对我们研究方向感兴趣的同志报考研究生或联系实验工作。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

SELECTED PUBLICATIONS

Nie FY, Tian JH, Lin XD, Yu B, Xing JG, Cao JH, Holmes EC, Ma RZ, Zhang YZ. (2019). Discovery of a highly divergent hepadnavirus in shrews from China. Virology, 531, 162-170. doi: 10.1016/j.virol.2019.03.007

Abdel-Fatah TMA, Broom RJ, Lu J, Moseley PM, Huang B, Li L, Liu S, Chen L, Ma RZ, Cao W, Wang X, Li Y, Perry JK, Aleskandarany M, Nolan CC, Rakha EA, Lobie PE, Chan SYT, Ellis IO, Hwang LA, Lane DP, Green AR, Liu DX. (2019) SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment. Br J Cancer. doi: 10.1038/s41416-019-0405-x

Nie FY, Lin XD, Hao ZY, Chen XN, Wang ZX, Wang MR, Wu J, Wang HW, Zhao G, Ma RZ, Holmes EC, Zhang YZ. (2018) Extensive diversity and evolution of hepadnaviruses in bats in China. Virology, 514, 88-97. doi: 10.1016/j.virol.2017.11.005

Jin J, Shi X, Li Y, Zhang Q, Guo Y, Li C, Tan P, Fang Q, Ma Y, Ma RZ. (2018) Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol, 59(3), 320-333. doi: 10.1165/rcmb.2017-0347OC

Gong F, Guo Y, Niu Y, Jin J, Zhang X, Shi X, Zhang L, Li R, Chen L, Ma RZ. (2017) Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma. Oncotarget, 8(1), 315-328. doi: 10.18632/oncotarget.13324

Zhang X, Ling Y, Guo Y, Bai Y, Shi X, Gong F, Tan P, Zhang Y, Wei C, He X, Ramirez A, Liu X, Cao C, Zhong H, Xu Q, Ma RZ. (2016) Mps1 kinase regulates tumor cell viability via its novel role in mitochondria. Cell Death Dis. 2016 Jul 7;7(7):e2292. doi: 10.1038/cddis.2016.193.

Hou Y, Li Y, Gong F, Jin J, Huang A, Fang Q, Ma RZ. (2016) A Preliminary Study on RCN3 Protein Expression in Non-small Cell Lung Cancer. Clin Lab. 62(3):293-300.

Jin J, Li Y, Ren J, Man Lam S, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ. (2016) Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 54(3):410-423. doi: 10.1165/rcmb.2015-0036OC.

Zhang X, Pei L, Li R, Zhang W, Yang H, Li Y, Guo Y, Tan P, Han JJ, Zheng X, Ma RZ. (2016) Spina bifida in fetus is associated with an altered pattern of DNA methylation in placenta. J Hum Genet. 60(10):605-611

Jia H, Zhang X, Wang W, Bai Y, Ling Y, Cao C, Ma RZ, Zhong H, Wang X, Xu Q. (2015) A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphase. BMC Cell Biol. 2015 Feb 27;16:6. doi: 10.1186/s12860-015-0048-6.

Jung Y, Abdel-Fatah TM, Chan SY, Nolan CC, Green AR, Ellis IO, Li L, Huang B, Lu J, Xu B, Chen L, Ma RZ, Zhang M, Wang J, Wu Z, Zhu T, Perry JK, Lobie PE, Liu DX.（2014）SHON is a novel estrogen-regulated oncogene in mammary carcinoma that predicts patient response to endocrine therapy. Cancer Res. 73(23):6951-6962.

Ling Y, Zhang X, Bai Y, Li P, Wei C, Song T, Zheng Z, Guan K, Zhang Y, Zhang B, Liu X, Ma RZ, Cao C, Zhong H, Xu Q. (2014) Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy. Biochem Biophys Res Commun. 450(4):1690-1695.

Zhang P, Liu P, Dou H, Chen L, Chen L, Lin L, Tan P, Vajta G, Gao J, Du Y, Ma RZ. (2013) Handmade cloned transgenic sheep rich in omega-3 Fatty acids. PLoS One. 8 (2):e55941. doi: 10.1371.

Shi H, Qi X, Zhong H, Peng Y, Zhang X, Ma RZ, Su B. (2013) Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N. PLoS One. 8(6):e66102. doi: 10.1371/ journal.pone.0066102

Wang J, Zhu Z, Wang H, Li F, Du X, Ma RZ. (2013) Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs. Int J Oncol. Jun 19. doi: 10.3892/ijo.2013.1987.

Zhang X, Ling Y, Wang W, Zhang Y, Ma Q, Tan P, Song T, Wei C, Li P, Liu X, Ma RZ, Zhong H, Cao C, Xu Q. (2013) UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores. Cell Cycle. Apr 15; 12 (8):1292-302. doi: 10.4161/cc.24403.

Li G, Liu K, Jiao S, Liu H, Blair HT, Zhang P, Cui X, Tan P, Gao J, Ma RZ. (2012) A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb. BMC Genomics. 16;13(1):398-404.

Zhang P, Zhang Y, Dou H, Yin J, Chen Y, Pang X, Vajta G, Bolund L, Du Y, Ma RZ. (2012) Handmade cloned transgenic piglets expressing the nematode fat-1 gene. Cell Reprogram. 14(3):258-266.

Wu X, Zhang Y, Chen S, Xu Y, Pei Z, Lin D, Chen Y, Ma RZ. (2012) Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2. BMC Cancer. 28;12(1):192-198.

Chen L, Liu K, Zhao Z, Blair HT, Zhang P, Li D, Ma RZ. (2012) Identification of sheep ovary genes potentially associated with off-season reproduction. J Genet Genomics. 39(4):181-190.

Zhong H, Li XL, Li M, Hao LX, Chen RW, Xiang K, Qi XB, Ma RZ, Su B. (2011) Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population. Arthritis Res Ther. 13 (6): R186.[Epub ahead of print]

Zhang X, Yin Q, Ling Y, Zhang Y, Ma RZ, Ma Q, Cao C, Zhong H, Liu X, Xu Q. (2011) Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses. Cell Cycle. 10 (16):2742-50.

Zhong H, Shi H, Qi XB, Duan Z, Tan P, Jin L, Su B, Ma RZ. (2011) Extended Y-chromosome investigation suggests post-Glacial migrations of modern humans into East Asia via the northern route. Mol Biol Evol 28(1):717-727.

Liu K, Zhang P, Gao J, Liu H, Li G, Qiu Z, Zhang Y, Ren J, Tan P, Ma RZ. (2011) Closing a gap in the physical map of the ovine major histocompatibility complex. Animal Genetics 42(2):204-207.

Peng Y, Shi H, Qi XB, Xiao CJ, Zhong H, Ma RZ, Su B. (2010) The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history. BMC Evol Biol 10:15-22.

Gao J, Liu K, Liu H, Blair HT, Li G, Chen C, Tan P, Ma RZ. (2010) A complete DNA sequence map of the ovine Major Histocompatibility Complex. BMC Genomics. 11(1):466-474.

Zhong H, Shi H, Qi XB, Xiao CJ, Jin L, Ma RZ, Su B. (2010) Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia. J Hum Genet. 55(7):428-435.

Liu L, Yin J, Li W, Liu K, Peng Y, Tan P, Ma RZ. (2010) Construction of a bacterial artificial chromosome library for the Rongchang pig breed and its use for the identification of genes involved in intramuscular fat deposition. Biochem Biophys Res Commun. 391: 1280-1284.

Song J, Zhang X, Qi Z, Sun G, Chi S, Zhu Z, Ren J, Qiu Z, Liu K, Myatt L, Ma RZ. (2009) Cloning and Characterization of a Calcium-Activated Chloride Channel in Rat Uterus. Biol Reprod. 80: 788-794.

Shi H, Tan SJ, Zhong H, Hu W, Levine A, Xiao CJ, Peng Y, Qi XB, Shou WH, Ma RL, Li Y, Su B, Lu X. (2009) Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. Am J Hum Genet. 84: 534-541

Shi H, Zhong H, Peng Y, Dong YL, Qi XB, Zhang F, Liu LF, Tan SJ, Ma RZ, Xiao CJ, Wells RS, Jin L, Su B. (2008) Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations. BMC Biol. 29, 6:45.

Wei H, Ding X, Ren J, Liu K, Tan P, Li D, Ma RZ. (2008) A murine model for human immune thrombocytopenic purpura and comparative analysis of multiple gene expression in bone marrow and spleen. J Genet Genomics. 35(11):665-671.

Zhang Y., Dasgupta J., Ma RZ, Banks L., Thomas M., Chen X.S. (2007) Structures of a HPV-E6 polypeptide bound to MAGUK proteins: Mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J. Virology 81:3618-3626.

Zhang X., Zhu Z., Huang C., Tan P., Ma RZ (2007) Microsatellite genotyping for four expected inbred mouse strains from KM mice. J Genet Genomics. 34:214-222.

Liu HB，Liu K，Wang JF，Ma RZ. (2006) A BAC-based physical map of Ovine Major Histocompatibility Complex (MHC). Genomics, 88:88-95.

Szakonyi G, Klein MG, Hannan JP, Young KA,Ma RZ, Asokan R, Holers VM, Chen XS. (2006) Structure of the Epstein-Barr virus major envelope glycoprotein. Nat Struct Mol Biol. 13, 996-1001.

Liu YF,Ma RL, Wang SL, Duan ZY, Zhang JH, Wu LJ, Wu CF. (2003) Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli. Protein Expres and Purif. 27(2):253-258.

Sun K, Ma RZ, Cui X, Campos B, Webster R, Brockman D, Myatt L. (2003) Glucocorticoids Induce Cytosolic Phospholipase A (2) and Prostaglandin H Synthase Type 2 But Not Microsomal Prostaglandin E Synthase (PGES) and Cytosolic PGES Expression in Cultured Primary Human Amnion Cells. J Clin Endocrinol Metab 88: 5564-5571.

Butterfield R.J., Roper R.J., Rhein D.M., Melvold R.W., Haynes L, Ma RZ, Doerge R.W., Teuscher C. (2003) Sex-Specific Quantitative Trait Loci Govern Susceptibility to Theiler’s Murine Encephalomyelitis Virus-Induced Demyelination. Genetics 163:1041-1046.

Ma RZ, Gao J., Meeker N.D., Fillmore P.D., Tung K.S.K., Watanabe T., Blankenhorn E.B. and Teuscher C. (2002) Identification of Bphs, an autoimmune diseases locus, as histamine receptor H1. Science 297:620-623.

Roper R.J., Ma, RZ, Biggins, J.E., McAllister, R.D., Min, S., Call, S.B., Butterfield, R.J., Michael S.M., Tung, K.S.K., Doerge, R.W., and Teuscher, C. (2002) Genetic Control of Immunoregulation, Loss of Peripheral Tolerance, and Autoimmune Ovarian Dysgenesis after Day Three Thymectomy in Mice. J Immunol 169:1640-1646.

Ambady S, Kappes SM, Park C, Ma RZ, Beever JE, Lewin HA, Smith TP, Beattie CW, Basrur PK, Ponce de Leon FA. (2001) Development and mapping of microsatellites from a microdissected BTA 11-specific DNA library. Animal Genetics 32:152-155.

Kim K.I, Yang Y.H, Lee S.S, Park C, Ma RZ, Bouzat J.L, Lewin H.A. (1999) Phylogenetic relationships of Cheju horses to other horse breeds as determined by mtDNA D-loop sequence polymorphism. Animal Genetics 30:102-108.

Meeker N.D., A.N. Stafford, J.K. Lunceford, P. Avner, RZ Ma and C. Teuscher. (1999) Physical mapping of the autoimmune disease susceptibility locus, Bphs: Co-localization with a cluster of genes from the TNF receptor superfamily on mouse chromosome 6. Mamm Gemone 10:858-863.

Teuscher C, Butterfield R.J, Ma RZ, Zachary J.F, Doerge R.W, Blankenhorn E.P. (1999) Sequence polymorphisms in the chemokines scya1 (TCA-3), scya2 (Monocyte chemoattractant protein (MCP)-1), and scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic Remitting/Nonrelapsing experimental allergic encephalomyelitis. J Immunol 163:2262-2266.

Da Y, P.M. VanRaden, M. Ron, J.E. Beever, A.A. Paszek, J. Song, G.R. Wiggans, Ma R, J.I. Weller, H.A. Lewin. (1999) Standardization and conversion of marker polymorphism measures. Anim Biotecol 10:25-35.

Ma RZ, J.C. Reese and W.C. Black IV. (1999) Chlorophyll loses in the sorghum susceptible to greengubs (Schizaphis graminum). J Kansas Ent Soc 71:51-60.

Taylor J.F., A. Eggen, A. Aleyasin, S.M. Armitage, W. Barendse, J.E. Beever, M.D. Bishop, R.A. Brenneman, B.M. Burns, S.K. Davis, K. Elo, B. Harlizius, S.M. Kappes, J.W. Keele, J.S. Kemp, B.W. Kirkpatrick, H.A. Lewin, RZ Ma, R.A.McGraw, D. Pomp, R.T. Stone, Y. Sugimoto, A.J. Teale, D. Vaiman, M.C. Zanotti, et al. (1998) Report of the first workshop on the genetic map of bovine chromosome 1. Animal Genetics 29:228-235.

Ma, RZ, M.J.T. van Eijk, J.E. Beever, G. Guèrin, C.L. Mummery, H.A. Lewin. (1998) Comparative analysis of 82 expressed sequence tags from a bovine ovary cDNA library. Mamm Genome 9:545-549.

Zhang, A. W., G. L. Hartman, L. Riccioni, W. D. Chen, RZ Ma and Pedersen. (1997) Using PCR to distinguish Diaporthe phaseolorun and Phomopsis longicolla from other soybean fungal pathogens and to detect them in soybean tissues. Plant Disease 81:1143-1149.

Ma, RZ, J. E. Beever, Y. DA, C. A. Green, I. Russ, C. Park, D. W. Heyen, R. E. Everts, A. J. Teale, S. J. Kemp, H. C. Hines, G. Guérin and H. A. Lewin. (1996) A male linkage map of the cattle (Bos taurus) genome. J Heredity 87:261-271.

Beever, J. E., H. A. Lewin, W. Barendse, L. Andersson, S. M. Armitage, C. W. Beattie, B. M. Burns, S. M. Kappes, B. W. Kirkpatrick, RZ Ma, R. A. McGraw, R. T. Stone and J. F. Taylor. (1996) Report on the first workshop on the genetic map of bovine chromosome 23. Animal Genetics 27:69-75.

Ma, RZ, I. Russ, C. Park, D. W. Heyen, J. E. Beever, C. A. Green and H. A. Lewin. (1996) Isolation and characterization of 45 polymorphic microsatellites from the bovine genome. Animal Genetics 27:43-47.

Kemp, S. J., O. Hishida, J. Wambugu, A. Rink, RZ Ma, Y. Da, H.A. Lewin, W. Barendse and A. J. Teale. (1995) A panel of bovine, ovine and caprine microsatellites. Animal Genetics 26:299-306.

Shalhevet, D., D. Yang, J. E. Beever, M. J. T. van Eijk, R. Ma, H. A. Lewin and H. R. Gaskins. (1995) Genetic mapping of the LMP2 proteasome subunit gene to the BoLA class IIb region. Immunogenetics 41:44-46.

Ma, R., M. B. Cohen, M. R. Berenbaum and M. A. Schuler. (1994) Black Swallowtail (Papillio polyxenes) alleles encode Cytochrome P-450s that selectively metabolize linear furanocumarins. Arch Biochem Biophysics 310:332-340.

Ma, RZ, D. Swedenborg and R. L. Jones. (1992) Host seeking behavior of Eriborus terebrans (Hymenoptera: Ichneumonidae) toward the European corn borer (Ostrinia nubilalis), and the role of chemical stimuli. Ann Ent Soc Amer 85:72-79.

Ma, RZ, W. C. Black IV and J. C. Reese. (1992) Genome size and organization in an aphid (Schizaphis graminum). J Insect Physiol 38:161-165.

Ma, R, J. C. Reese, W. C. Black IV and P. J. Bramel-Cox. (1990) Detection of pectinesterase and polygalacturonase from salivary secretions of living greenbugs (Schizaphis graminum) (Homoptera: Aphididae). J Insect Physiol. 37:507-512.

Book and Chapters

Chen LX, Li RT, and Ma RZ. (2014) Potentials of RNA Aptamers for viral detection and treatment. In RNA Nanotechnology and Therapeutics (Eds. Guo PX & Haque F.) CRC Press Taylor & Francis Group. pp. 449-463.