姓  名: 丁梅
    职  称: 研究员
    电话/传真: 86-10-64806236
    电子邮件: mding@genetics.ac.cn
    研究方向: 神经元应激和稳态维持

    简历介绍:

    丁梅,博士, 研究员,博士生导师
        1995年厦门大学学士, 2004年美国加州大学圣克鲁斯分校(University of California, Santa Cruz)获博士学位,2004至2008年美国斯坦福大学(Stanford University)博士后。2008年任中国科学院遗传与发育生物学研究所研究员,博士生导师,国家自然科学基金委“国家优秀青年科学基金”获得者。

    研究领域:

    主要研究方向
      在神经系统发育完成后,成熟神经元在其生命周期中需应对外界环境变化、代谢波动及衰老等挑战。然而,神经元如何通过自我调节维持其通讯功能及与周围组织的相互作用,这一机制尚未完全阐明。本课题组聚焦神经元慢性应激反应、细胞外囊泡的动态调控及线粒体形态重塑等关键科学问题,结合多尺度成像技术、分子、细胞及发育生物学等手段,致力于揭示神经元稳态维持的核心调控因子,阐明细胞间物质交换与信号传递的分子机制及其生物学意义。

    代表论著:

    发表论文(*为通讯作者):
    Wu Z, Pang L, Ding M*. (2025). CFI-1 functions unilaterally to restrict gap junction formation in C. elegans. Development. 152(1): dev202955. doi: 10.1242/dev.202955.
    Miao Y#, Du Y#, Wang B, Liang J, Liang Y, Dang S, Liu J, Li D, He K*, Ding M*. (2024). Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation. elife. 13:RP96353. doi: 10.7554/elife.96353.
    Guan L#, YangY#, Jing Liang L#,Miao Y, Shang A, Wang B,Wang Y, Ding M*. (2022). ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Traffic. 23(3):140-157. doi: 10.1111/tra.12830. 
    Cong D#, Ren J#, Zhou Y, Wang S, Liang J, Ding M*, FengW*. (2021) Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A. PLoS Genetics doi: 10.1371/journal.pgen.1009940.
    Yang L, Liang J, Lam S-M, Yavuz A, Shui G, Ding M and Huang X*. (2020) Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. EMBO Reports 21:e50214 PMID: 33034119.
    Guan L#, Zhan Z#, Yang Y, Miao Y, Huang X, and Ding M*. (2020) Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons. PLoS Genetics 16(9):e1008704.
    Ji J, Yuan J, Guo X, Ji R, Quan Q, Ding M*,Li X*, and Liu Y*. (2019) Harmine suppresses hyper-activated Ras-MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans. Cancer Cell Int doi: 10.1186/s12935-019-0880-4.
    Guo X, Yuan J, Song X, Wang X, Sun Q, Tian J,Li X*,Ding M*, and Liu Y*. (2019) Bacteria metabolites from Peganum harmala L. polysaccharides inhibits polyQ aggregation through proteasome-mediated protein degradation inC. elegans. Int J Biol Macromol doi: 10.1016/j.ijbiomac.2020.06.091.
    Yang X, Liang J, Ding L, Li X, Lam S-M, Shui G, Ding M and Huang X*. (2019) Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLoS Genetics15:e1008548 PMID: 31869331
    Wang J and Ding M*. (2018) Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in C. elegans. PNAS doi:10.1073/pnas.1717468115.
    Yao Y, Li X, Wang W, Liu Z, Chen J, Ding M and Huang X*. (2018) MRT, functioning with NURF complex, regulates lipid droplet size. Cell Reports 24:2972-2984 PMID: 30208321
    Ding L, Yang X, Tian H, Liang J, Zhang F, Wang G, Wang Y, Ding M, Shui G and Huang X*. (2018) Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J. 37:e97572PMID: 30049710
    Guan L#, Ma X#, Zhang J, Liu J, Wang Y, and Ding M*. (2016) The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS GeneticsJul 14;12(7):e1006163. 
    Cheng Y#, Wang J#, Wang Y, and Ding M*. (2015) Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife 4:e05118.
    Wu J, Cheng Y, Wang J, Chen L, Ding M, and Wu J*.(2015) Structural insight into the mechanism of synergic autoinhibition of SAD kinases. Nature Communications DOI:10.1038/ncomms9953.
    Wang J, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M* and Huang X*. (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development142:1447-1457.
    Qin J, Liang J, and Ding M*. (2014) Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons. Journal of Neuroscience34(31):10311-10324.
    Zhang J, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X*, andDing M*.(2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics9(6): e1001056.
    Song S#, Zhang B#, Sun H, Li X, Xiang Y, Liu Z, Huang X*, andDing M*. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics6(8): e1003618.
    Ding M*and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay 30: 1075-1083.
    Ding M, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PloS One 3: e3346.
    Ding M, Chao D, Wang G, Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317, 947-951.
    Ding M, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res 301:84-90.
    Ding M, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development 130:5791-5801.