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    姓　　名： 李传友
    职　　称： 研究员
    职　　务：
    电话/传真： 86-10-64806612(O);86-10-64806610(L)
    电子邮件： cyli@genetics.ac.cn
    实验室主页：
    研究方向： 茉莉酸作用机理与番茄功能基因组学

    简历介绍：

    李传友，博士，研究员，博士生导师。
        1991年山东农业大学学士；1994年山东农业大学硕士；1999年中国科学院遗传研究所博士。1999年至2003年，MSU-DOE Plant Research Laboratory博士后。2004年国家杰出青年科学基金获得者。担任国家重大科学研究计划项目首席科学家,主要学术兼职包括《Molecular Plant》、《Horticulture Research》、《Plant Molecular Biology》等国际著名刊物编委。作为执行委员会委员和中方联络人组织实施了国际茄科基因组计划，完成了栽培番茄与其起源种醋栗番茄基因组的精细序列分析。组织召开了第286次香山科学会议“植物激素与绿色革命”和第479次香山科学会议“植物发育与生殖：前沿科学问题与发展战略”。作为学术秘书申请并组织实施了国家自然科学基金委首个重大研究计划项目“植物激素作用的分子机理”（2008–2016年）并在结题验收中获得优秀。
        李传友研究组长期研究植物系统性防御与可塑性发育的机理。创造性地把植物受伤反应分为防御与再生两个密不可分的生理过程，破译了逆境条件下植物通过改变干细胞活性协同调控适应性生长和抗性的分子机制，发现了调控植物组织修复和器官再生的原初受伤信号——再生因子REF1并揭示了其在作物遗传改良中的巨大应用价值。精细解读了模式植物番茄的基因组，致力于健康美味番茄精准设计育种。在Cell、Nature、Nature Plants、PNAS、Molecular Plant、Plant Cell等国际主流学术刊物发表论文130余篇，引用12000余次。在国际权威出版社ELSEVIER出版英文专著《Hormone Metabolism and Signaling in Plants》。H-index为57。入选Clarivate Analytics（科睿唯安）全球前1%高被引学者名单，连续四年入选ELSEVIER（爱思唯尔）中国高被引学者名单。申请PCT专利1项，获得授权专利20余项、植物新品种权2项，育成农业农村部登记番茄品种7个。

    研究领域：

    主要研究内容：
        1. 茉莉酸作用机理
        茉莉酸既调控植物免疫，又在植物可塑性发育中发挥重要作用。茉莉酸信号通路的实质是核心转录因子MYC2介导的转录重编程。一方面，我们研究中介体亚基MED25与MYC2形成的功能复合体MMC (MYC2-MED25 Functional Transcription Complex)在茉莉酸信号的激活、级联放大、终止以及精细调控中的作用机制；另一方面，我们研究免疫激素茉莉酸与生长激素互作通过改变干细胞活性调控植物可塑性发育和器官再生的机理。

        2. 植物防御与再生机理
        与动物相比，固着生长的植物更易遭受机械损伤。在长期的进化过程中，植物形成了动物不可比拟的应对损伤的能力。面对损伤，植物能快速激活防御反应，并轻松自如地进行组织修复和器官再生。在番茄中，人们发现了植物对机械损伤的系统性防御现象，并证实小肽激素系统素(systemin)和经典激素茉莉酸通过共同的信号通路调控植物的系统性防御反应。相比而言，人们对损伤引发植物再生的原初信号及其转导机制知之甚少。我们以番茄为模式，建立了用正向遗传学手段解析植物受伤反应的研究体系。一方面，我们进行了大规模的遗传筛选获得了一系列系统素信号通路的抑制子(suppressor of prosystemin-mediated responses, spr)，通过对这些防御缺陷突变体的研究分离关键组分，在此基础上解析植物的系统性防御反应的调控机理。另一方面，我们创造性地提出在植物受伤反应中防御功能与再生功能是密不可分的这一全新理念，据此从分析防御缺陷突变体的再生表型入手鉴定防御和再生同时发生缺陷的突变体，找到了诱发植物再生的原初受伤信号分子—再生因子REF1，在此基础上系统解析植物组织修复和器官再生的信号网络。

        3. 番茄重要农艺性状形成机理解析与种质创新
        开展番茄功能基因组学研究，与国际同行一道完成了栽培番茄及其起源种醋栗番茄基因组的精细序列分析。聚焦番茄对重大病害（土传病害颈腐根腐病、青枯病，死体营养型病害灰霉病、灰叶斑病，褐色皱果病毒病等）的抗性和品质（风味品质、营养品质和健康品质）等重要农艺性状，从丰富的种质资源入手，鉴定控制番茄抗病性和优质的关键基因，阐明番茄抗病性和品质性状形成的分子机理。鉴定关键抗性基因和优质基因的优异单倍型，解析其驯化和演化规律，创制对番茄抗性和果实品质提升有显著效应的新种质。

        4. 健康美味番茄生物育种
        针对目前对抗性与品质互作机制认识不足的现状，聚焦影响番茄品质的重要病害，建立抗性与品质互作的研究模型，解析番茄抗性与品质基因互作的遗传与代谢基础，发掘同时控制抗性和品质性状形成的节点基因，创制对综合性状提升有显著效应的番茄新种质。在此基础上，采取基因组设计和生物育种新手段，培育营养健康、绿色高效的美味番茄新品种。

    媒体报道：
    1. 【中央电视台】CCTV2《中国经济大讲堂》——“餐桌上的大科技：小番茄如何变身大‘柿’业？”
     
    2. 【中央电视台】CCTV10《透视新科技》——番茄变身记
     
    3. 【中央电视台】CCTV1《新闻联播》——我国主导完成番茄基因组测序
     
    4. 【中央电视台】CCTV13《新闻直播间》——关注番茄基因组测序 我国主导完成番茄基因组测序
     
    5. 【中央电视台】CCTV13《新闻直播间》——关注番茄基因组测序 基因“争夺”：没有硝烟的战争
     
    6. 【CC讲坛】李传友：揭秘番茄的智慧
     
    7. 【民生周刊】小番茄里有“大智慧”，https://www.msweekly.com/mobile/show.html?id=139081
     
    8. 【农民日报】丢掉的番茄味，是怎样找回来的？，https://baijiahao.baidu.com/s?id=1739376282136753673&wfr=spider&for=pc

    社会任职：

    获奖及荣誉：

    承担科研项目情况：

    代表论著：

    KEY PUBLICATIONS (*Corresponding author):
    1. Yang W, Zhai H, Wu F, Deng L*, Chao Y, Meng X, Chen Q, Liu C, Bie X, Sun C, Yu Y, Zhang X, Zhang X, Chang Z, Xue M, Zhao Y, Meng X, Li B, Zhang X, Zhang D, Zhao X, Gao C, Li J, and Li C*. (2024). Peptide REF1 is a local wound signal promoting plant regeneration. Cell 187: 3024–3038.
    新闻公众号：专家点评 Cell | 破解世纪难题——李传友团队首次发现再生因子调控植物组织修复和器官再生，https://mp.weixin.qq.com/s/yc8b5GRtIb-46Xg-FuASDQ
     
    2. Han H, Li X, Li T, Chen Q, Zhao J, Zhai H, Deng L, Meng X*, and Li C*. (2024). Chromosome-level genome assembly of Solanum pimpinellifolium. Sci. Data 11: 577.
     
    3. Yang T, Deng L*, Wang Q, Sun C, Ali M, Wu F, Zhai H, Xu Q, Xin P, Cheng S, Chu J, Huang T, Li C-B, and Li C*. (2024). Tomato CYP94C1 inactivates bioactive JA-Ile to attenuate jasmonate-mediated defense during fruit ripening. Mol. Plant 17: 509–512.
    新闻公众号：李传友团队揭示果实成熟更易腐烂的分子机理并提出打破番茄优质与高抗负相关新策略，https://mp.weixin.qq.com/s/1w7aZWmPSJfLD8DJfEfeFg
     
    4. Liu J, Zhang C, Sun H, Zang Y, Meng X, Zhai H, Chen Q*, and Li C*. (2024) A natural variation in SlSCaBP8 promoter contributes to the loss of saline-alkaline tolerance during tomato improvement. Hortic. Res.10: uhae055.
     
    5. Wang Y, Sun C, Ye Z, Li C, Huang S, and Lin T*. (2024). The genomic route to tomato breeding: Past, present, and future. Plant Physiol. DOI: 10.1093/plphys/kiae248
     
    6. Zhu Q, Deng L, Chen J, Rodriguez GR, Sun C, Chang Z, Yang T, Zhai H, Jiang H, Topcu Y, Francis D, Hutton S, Sun L, Li C-B, van der Knaap E, and Li C* (2023). Redesigning the tomato fruit shape for mechanized production. Nat. Plants 9: 1659–1674.
    Highlighted with a News article in Science, https://doi.org/10.1126/science.adk9188
     
    7. Deng L*, Yang T, Li Q, Chang Z, Sun C, Jiang H, Meng X, Huang T, Li C-B, Zhong S, and Li C*. (2023). Tomato MED25 regulates fruit ripening by interacting with EIN3-like transcription factors. Plant Cell 35: 1038–1057.
    Highlighted with an In Brief article in Plant Cell, https://doi.org/10.1093/plcell/koad015
    新闻公众号：中科院遗传发育所李传友研究组揭示番茄果实成熟调控新机理，https://mp.weixin.qq.com/s/Z0fqI2o3daODidIAbpL60g
     
    8. Yang T, Ali M, Lin L, Li P, He H, Zhu Q, Sun C, Wu N, Zhang X., Huang T, Li C-B, Li C*, and Deng L*. (2023). Recoloring tomato fruit by CRISPR/Cas9-mediated multiplex gene editing. Hortic. Res. 10: uhac214. (Cover story)
    新闻公众号：中科院遗传发育所李传友课题组通过多重基因编辑实现番茄多种果色的快速同步定制，https://mp.weixin.qq.com/s/QKNDQI3WA5VAaPPg1QZd2A
     
    9. Zhou M, Deng L, Yuan G, Zhao W, Ma M, Sun C, Du M*, Li C*, and Li C-B*. (2023). Rapid generation of a tomato male sterility system and its feasible application in hybrid seed production. Theor. Appl. Genet. 136: 197.
     
    10. Zhou M, Deng L, Yuan G, Zhao W, Ma M, Sun C, Du M, Li C, and Li C-B*. (2023). A CRISPR-Cas9-derived male sterility system for tomato breeding. Agronomy 13: 1785.
     
    11. Zhao Q, Zhao P, Wu Y, Zhong C, Liao H, Li C, Fu X, Fang P, Xu P*, and Xiang C*. (2023). SUE4, a novel PIN1-interacting membrane protein, regulates acropetal auxin transport in response to sulfur deficiency. New Phytol. 237: 78–87.
     
    12. An C, Deng L, Zhai H, You Y, Wu F, Zhai Q, Goossens A, and Li C*. (2022). Regulation of jasmonate signaling by reversible acetylation of TOPLESS in Arabidopsis. Mol. Plant 15: 1329–1346.
    Highlighted with a Spotlights article in Molecular Plant, https://doi.org/10.1016/j.molp.2022.07.015
    新闻公众号：李传友研究组发现转录共抑制子TOPLESS通过可逆乙酰化修饰调控茉莉酸信号通路，https://mp.weixin.qq.com/s/HuoKcu40AaFnjupqcsQmyA
     
    13. Du M, Daher F, Liu Y, Steward A, Tillmann M, Zhang X, Wong J, Ren H, Cohen J, Li C*, and Gray W*. (2022). Biphasic control of cell expansion by auxin coordinates etiolated seedling development. Sci. Adv. 8: eabj1570.
    新闻公众号：Science Advances | 打破传统认知，李传友研究组合作解析植物顶端弯钩的形成机制，https://mp.weixin.qq.com/s/mtrVwMLS2fkyQxG15RSbrw
     
    14. Lin L, Du M, Li S, Sun C, Wu F, Deng L, Chen Q*, and Li C*. (2022). Mediator complex subunit MED25 physically interacts with DST to regulate spikelet number in rice. J. Integr. Plant Biol. 64: 871–883
     
    15. Zhou M, Deng L, Guo S, Yuan G, Li C*, and Li C-B*. (2022). Alternative transcription and feedback regulation suggest that SlIDI1 is involved in tomato carotenoid synthesis in a complex way. Hortic. Res. 9: uhab045. (Cover story)
     
    16. Tao H, Miao H, Chen L, Wang M, Xia C, Zeng W, Sun B, Zhang F, Zhang S, Li C*, and Wang Q*. (2022). WRKY33-mediated indolic glucosinolate metabolic pathway confers resistance against Alternaria brassicicola in Arabidopsis and Brassica crops. J. Integr. Plant Biol. 64: 1007–1019.
     
    17. Lian J, Han H, Chen X, Chen Q, Zhao J*, and Li C*. (2022). Stemphylium lycopersici Nep1-like protein (NLP) is a key virulence factor in tomato gray leaf spot disease. J. Fungi 8: 518.
     
    18. Sun C, Li D, Gao Z, Gao L, Shang L, Wang M, Qiao J, Ding S, Li C, Geisler M, Jiang D, Qi Y*, and Qian Q*. (2022). OsRLR4 binds to the OsAUX1 promoter to negatively regulate primary root development in rice. J. Integr. Plant Biol. 64: 118-134.
     
    19. Tu T, Zheng S, Ren P, Meng X, Zhao J, Chen Q*, and Li C*. (2021). Coordinated cytokinin signaling and auxin biosynthesis mediates arsenate-induced root growth inhibition. Plant Physiol. 185: 1166–1181.
     
    20. Liu H, Liu L, Liang D, Zhang M, Jia C, Qi M, Liu Y, Shao Z, Meng F, Hu S, Yin Y*, Li C*, and Wang Q*. (2021). SlBES1 promotes tomato fruit softening through transcriptional inhibition of PMEU1. iScience 24: 102926.
     
    21. Zheng S, Ren P, Zhai M, Li C*, and Chen Q*. (2021). Identification of genes involved in root growth inhibition under lead stress by transcriptome profiling in Arabidopsis. Plant Mol. Biol. Rep. 39: 50–59.
     
    22. Guo P, Chong L, Wu F, Hsu C, Li C, Zhu J-K, and Zhu Y*. (2021). Mediator tail module subunits MED16 and MED25 differentially regulate abscisic acid signaling in Arabidopsis. J. Integr. Plant Biol. 63: 802–815.
     
    23. Zhai Q, Deng L, and Li C*. (2020). Mediator subunit MED25: at the nexus of jasmonate signaling. Curr. Opin. Plant Biol. 57: 78–86.
    新闻公众号：Curr Opin Plant Biol | 李传友研究组应邀撰写茉莉酸信号通路转录调控机理的综述文章，https://mp.weixin.qq.com/s/EoLr2HDCllWA7TtDQ02XeA
     
    24. Zhai H, Zhang X, You Y, Lin L, Zhou W*, and Li C*. (2020). SEUSS integrates transcriptional and epigenetic control of root stem cell organizer specification. EMBO J. 39: e105047.
    新闻公众号：中科院遗传发育所李传友研究组揭示转录调控因子SEUSS调控干细胞命运决定的新机制，https://mp.weixin.qq.com/s/gYfoQGlUNC03udtVNH7RfQ
     
    25. Wu F, Deng L, Zhai Q, Zhao J, Chen Q, and Li C*. (2020). Mediator subunit MED25 couples alternative splicing of JAZ genes with fine-tuning of jasmonate signaling. Plant Cell 32: 429–448.
    新闻公众号：遗传所李传友组揭示可变剪切调控茉莉酸信号通路的机制，https://mp.weixin.qq.com/s/nKNFc8ZE99LVfe-Ii58DQA
     
    26. Du M*, Zhou K, Liu Y, Deng L, Zhang X, Lin L, Zhou M, Zhao W, Wen C, Xing J, Li C-B*, and Li C*. (2020). A biotechnology-based male-sterility system for hybrid seed production in tomato. Plant J. 102: 1090–1100.
    新闻公众号：李传友研究组合作研发新型番茄雄性不育系统用于杂交种子生产，https://mp.weixin.qq.com/s/KfW2m5ByBYqiiBwUWiPGzw
     
    27. You Y, An C, and Li C*. (2020). Insect feeding assays with Spodoptera exigua on Arabidopsis thaliana. Bio-protocol 10: e3538.
     
    28. Sun C, Deng L, Du M, Zhao J, Chen Q, Huang T, Jiang H, Li C-B*, and Li C*. (2020). A transcriptional network promotes anthocyanin biosynthesis in tomato flesh. Mol. Plant 13: 42–58. (Cover story).
    Highlighted with a Spotlights article in Molecular Plant, https://doi.org/10.1016/j.molp.2019.12.012
    新闻公众号：中科院遗传所李传友研究组在番茄花青素合成的转录调控机理研究中取得重要进展，https://mp.weixin.qq.com/s/sty4h0umk23F-K3THH9aMA
     
    29. Sun W, Han H, Deng L, Sun C, Xu Y, Lin L, Ren P, Zhao J, Zhai Q*, and Li C. (2020). Mediator Subunit MED25 Physically Interacts with PHYTOCHROME INTERACTING FACTOR4 to Regulate Shade-Induced Hypocotyl Elongation in Tomato. Plant Physiol. 184:1549–1562.
    Highlighted with a News and Views article in Plant Physiology, https://doi.org/10.1104/pp.20.01324
     
    30. Shao Z, Zhao Y, Liu L, Chen S, Li C, Meng F, Liu H, Hu S, Wang J, and Wang Q*. (2020). Overexpression of FBR41 enhances resistance to sphinganine analog mycotoxin-induced cell death and alternaria stem canker in tomato. Plant Biotechnol. J. 18: 141–154.
     
    31. Ren K, Tian X, Li S, Mei E, He M, Tang J, Xu M, Li X, Wang Z, Li C, and Bu Q*. (2020). Oryza sativa mediator subunit OsMED25 interacts with OsBZR1 to regulate brassinosteroid signaling and plant architecture in rice. J. Integr. Plant Biol. 62: 793–811.
     
    32. Zhu Y, Hu X, Duan Y, Li S, Wang Y, Rehman A, He J, Zhang J, Hua D, Yang L, Chen Z, Li C, Wang B, Song C, Sun Q, Yang S, Gong Z*. (2020). The Arabidopsis nodulin homeobox factor AtNDX interacts with AtRING1A/B and negatively regulates abscisic acid signaling. Plant Cell 32: 703–721.
     
    33. Guo H, Sun Y, Yan H, Li C, and Ge F*. (2020). O-3-induced priming defense associated with the abscisic acid signaling pathway enhances plant resistance to Bemisia tabaci. Front. Plant Sci. 11: 93.
     
    34. Yang T, Deng L, Zhao W, Zhang R, Jiang H, Ye Z*, Li C-B*, and Li C*. (2019). Rapid breeding of pink-fruited tomato hybrids using the CRISPR/Cas9 system. J. Genet. Genomics 46: 505–508. (Cover story)
     
    35. Wang H, Li S, Li Y, Xu Y, Wang Y, Zhang R, Sun W, Chen Q, Wang X, Li C*, and Zhao J*. (2019). MED25 connects enhancer-promoter looping and MYC2-dependent activation of jasmonate signaling. Nat. Plants 5: 616–625.
    新闻公众号：Nature Plants | 遗传所李传友/山东农大赵久海合作团队在植物转录增强子调控基因转录的机理研究中取得重要进展，https://mp.weixin.qq.com/s/_e3yMT_dmXtxVqtXZ-scxQ
     
    36. Liu Y, Du M, Deng L, Shen J, Fang M, Chen Q, Lu Y, Wang Q*, Li C*, and Zhai Q*. (2019). MYC2 regulates the termination of jasmonate signaling via an autoregulatory negative feedback loop. Plant Cell 31: 106–127.
    Highlighted with an In Brief article in Plant Cell, https://doi.org/10.1105/tpc.19.00004
    Highlighted with a Spotlight article in Trends Plant Sci., https://doi.org/10.1016/j.tplants.2019.06.001
     
    37. You Y, Zhai Q*, An C, and Li C*. (2019). LEUNIG_HOMOLOG mediates jasmonate-dependent transcriptional activation in cooperation with the coactivators HAC1 and MED25. Plant Cell 31: 2187–2205.
    新闻公众号：李传友研究组在茉莉酸信号转录调控机理研究中取得新进展，https://mp.weixin.qq.com/s/tEMvfo-ck64eymczhpk7sA
     
    38. Zhai Q, and Li C*. (2019). The plant Mediator complex and its role in jasmonate signaling. J. Exp. Bot. 70: 3415–3424.
     
    39. Zhou W, Lozano-Torres JL, Blilou I, Zhang X, Zhai Q, Smant G, Li C, and Scheres B*. (2019). A jasmonate signaling network activates root stem cells and promotes regeneration. Cell 177: 942–956.
     
    40. Zhang P, Wei J, Zhao C, Zhang Y, Li C, Liu S, Dickee M, Yu X, and Turlings TCJ*. (2019). Airborne host–plant manipulation by whiteflies via an inducible blend of plant volatiles. Proc. Natl. Acad. Sci. USA. 116: 7387–7396.
     
    41. Shi X, Preisser E, Liu B, Pan H, Xiang M, Xie W, Wang S, Wu Q, Li C, Liu Y, Zhou X, and Zhang Y*. (2019). Variation in both host defense and prior herbivory can alter plant-vector-virus interactions. BMC Plant Biol. 19: 556.
     
    42. Wang M, Qiao J, Yu C, Chen H, Sun C, Huang L, Li C, Geisler M, Qian Q, Jiang D, and Qi Y*. (2019). The auxin influx carrier, OsAUX3, regulates rice root development and responses to aluminium stress. Plant Cell Environ. 42: 1125–1138.
     
    43. Qi L, Zhang X, Zhai H, Liu J, Wu F, Li C*, and Chen Q*. (2019). Elongator is required for root stem cell maintenance by regulating SHORT ROOT transcription. Plant Physiol. 179: 220–232.
     
    44. Zhang R, Ge S, He J, Li S, Hao Y, Du H, Liu Z, Cheng R, Feng Y-Q, Xiong L, Li C, Hetherington A, and Liang Y-K*. (2019). BIG regulates stomatal immunity and jasmonate production in Arabidopsis. New Phytol. 222: 335–348.
     
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