姓  名: 孟文翔
    职  称: 研究员
    职  务:
    电话/传真: 86-10-64807922
    电子邮件: wxmeng@genetics.ac.cn
    实验室主页: http://menglab.genetics.ac.cn
    研究方向: 细胞生物学,发育生物学

    简历介绍:

    孟文翔,博士,研究员,博士生导师
            1995年北京中医药大学学士;2002年日本大阪大学医学博士;2002-2004在三重大学从事博士后研究。2004-2010年任日本理化学研究所发生再生综合研究中心研究员。2010年加入中国科学院遗传与发育生物学研究所。

    研究领域:

            主要研究方向为非中心体微管在细胞、个体发育以及疾病中的功能。
            微管包括中心体微管和非中心体微管,在细胞迁移、细胞分裂及囊泡运输等诸多生物学过程中发挥重要作用。在既往研究中,我们首次发现了非中心体微管负端结合蛋白,并命名为Nezha(Cell. 2008)。这个发现,是展开对非中心体研究的一个非常重要的切入点。我们以揭开非中心体微管的功能和调控机理为主要目标,目前建立了Nezha和PLEKHA7基因敲除小鼠模型,通过细胞生物学、生化学手法以及分子成像技术研究其在发生发育以及神经系统中的功能。我们还通过大规模质量分析技术发现并鉴定了一些与Nezha相互作用,可能参与非中心体微管的聚合和锚定的蛋白质。我们正在进一步研究这些蛋白分子在细胞内的功能,并建立基因敲除小鼠模型,深入探究它们在发生发育过程中的作用。

    社会任职:

    获奖及荣誉:

    承担科研项目情况:

    代表论著:

    发表论文:
    Hu, W., Zhang, R., Xu, H., Li, Y., Yang, X., Zhou, Z., Huang, X., Wang, Y., Ji, W., Gao, F., Meng, W. (2023). CAMSAP1 role in orchestrating structure and dynamics of manchette microtubule minus-ends impacts male fertility during spermiogenesis. Proc Natl Acad Sci U S A 120, e2313787120
    Zhang, R., Gu, L., Chen, W., Tanaka, N., Zhou, Z., Xu, H., Xu, T., Ji, W., Liang, X., Meng, W. (2023). CAMSAP2 and CAMSAP3 localize at microtubule intersections to regulate the spatial distribution of microtubules. J Mol Cell Biol.
    Fan, Z., Wang, S., Xu, C., Yang, J., Huang, X., Xu, H., Wang, Y., Meng, W., Cui, B. (2023). Fu Fang Gang Liu aqueous extract inhibits the proliferation of HeLa cells by causing deoxyribonucleic acid damage. J Ethnopharmacol 304, 116083
    Wu, W., Luo, S., Fan, C., Yang, T., Zhang, S., Meng, W., Xu, T., Ji, W., Gu, L. (2023). Tetra-color superresolution microscopy based on excitation spectral demixing. Light Sci Appl 12, 9
    Yuan, J., Ma, L., Wang, Y., Xu, X., Zhang, R., Wang, C., Meng, W., Tian, Z., Zhou, Y., Wang, G. (2023). A recently evolved BAHD acetyltransferase, responsible for bitter soyasaponin A production, is indispensable for soybean seed germination. J Integr Plant Biol 65, 2490-2504
    Jiang, D., Chen, F. X., Zhou, H., Lu, Y. Y., Tan, H., Yu, S. J., Yuan, J., Liu, H., Meng, W., Jin, Z. B. (2020). Bioenergetic Crosstalk between Mesenchymal Stem Cells and various Ocular Cells through the intercellular trafficking of Mitochondria. Theranostics 10, 7260-7272
    Zhou, Z., Xu, H., Li, Y., Yang, M., Zhang, R., Shiraishi, A., Kiyonari, H., Liang, X., Huang, X., Wang, Y., Xie, Q., Liu, S., Chen, R., Bao, L., Guo, W., Wang, Y., Meng, W. (2020). CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity. Proc Natl Acad Sci U S A 117, 22193-22203
    Chang, W. L., Liu, Y. W., Dang, Y. L., Jiang, X. X., Xu, H., Huang, X., Wang, Y. L., Wang, H., Zhu, C., Xue, L. Q., Lin, H. Y., Meng, W., Wang, H. (2018). PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development 145, 1-11
    Pongrakhananon, V., Saito, H., Hiver, S., Abe, T., Shioi, G., Meng, W., Takeichi, M. (2018). CAMSAP3 maintains neuronal polarity through regulation of microtubule stability. Proc Natl Acad Sci U S A 115, 9750-9755
    Dong, C., Xu, H., Zhang, R., Tanaka, N., Takeichi, M., Meng, W. (2017). CAMSAP3 accumulates in the pericentrosomal area and accompanies microtubule release from the centrosome via katanin. J Cell Sci 130, 1709-1715
    Shioi, G., Hoshino, H., Abe, T., Kiyonari, H., Nakao, K., Meng, W., Furuta, Y., Fujimori, T., Aizawa, S. (2017). Apical constriction in distal visceral endoderm cells initiates global, collective cell rearrangement in embryonic visceral endoderm to form anterior visceral endoderm. Dev Biol 429, 20-30
    Wang, J., Xu, H., Jiang, Y., Takahashi, M., Takeichi, M., Meng, W. (2017). CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells. J Genet Genomics 44, 39-49
    Wei, J., Xu, H., Meng, W. (2017). Noncentrosomal microtubules regulate autophagosome transport through CAMSAP2-EB1 cross-talk. FEBS Lett 591, 2379-2393
    Ning, W., Yu, Y., Xu, H., Liu, X., Wang, D., Wang, J., Wang, Y., Meng, W. (2016). The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics. Dev Cell 39, 61-74
    Toya, M., Kobayashi, S., Kawasaki, M., Shioi, G., Kaneko, M., Ishiuchi, T., Misaki, K., Meng, W., Takeichi, M. (2016). CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells. Proc Natl Acad Sci U S A 113, 332-337
    Popov, L. M., Marceau, C. D., Starkl, P. M., Lumb, J. H., Shah, J., Guerrera, D., Cooper, R. L., Merakou, C., Bouley, D. M., Meng, W., Kiyonari, H., Takeichi, M., Galli, S. J., Bagnoli, F., Citi, S., Carette, J. E., Amieva, M. R. (2015). The adherens junctions control susceptibility to Staphylococcus aureus alpha-toxin. Proc Natl Acad Sci U S A 112, 14337-14342
    Sako-Kubota, K., Tanaka, N., Nagae, S., Meng, W., Takeichi, M. (2014). Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions. Mol Biol Cell 25, 3851-3860
    Nagae, S., Meng, W., Takeichi, M. (2013). Non-centrosomal microtubules regulate F-actin organization through the suppression of GEF-H1 activity. Genes Cells 18, 387-396
    Tanaka, N., Meng, W., Nagae, S., Takeichi, M. (2012). Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules. Proc Natl Acad Sci U S A 109, 20029-20034
    Nagae, S., Meng, W. X., Takeichi, M. (2010). Nezha, a microtubule minus end-anchoring protein, regulates axon morphogenesis. Neurosci Res 68, E140-E140
    Meng, W., Takeichi, M. (2009). Adherens junction: molecular architecture and regulation. Cold Spring Harb Perspect Biol 1, a002899
    Meng, W (2009). Adherens Junction.(Short Review). PROTEIN, NUCLEIC ACID AND ENZYME 54,11(759), 5
    Meng, W., Mushika, Y., Ichii, T., Takeichi, M. (2008). Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell 135, 948-959
    Meng, W. X., Numazaki, M., Takeuchi, K., Uchibori, Y., Ando-Akatsuka, Y., Tominaga, M., Tominaga, T. (2004). DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner. EMBO J 23, 760-771
    Ariga, K., Yonenobu, K., Nakase, T., Hosono, N., Okuda, S., Meng, W., Tamura, Y., Yoshikawa, H. (2003). Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study. Spine (Phila Pa 1976) 28, 1528-1533
    Nakase, T., Ariga, K., Meng, W., Iwasaki, M., Tomita, T., Myoui, A., Yonenobu, K., Yoshikawa, H. (2002). Distribution of genes for parathyroid hormone (PTH)-related peptide, Indian hedgehog, PTH receptor and patched in the process of experimental spondylosis in mice. J Neurosurg 97, 82-87
    Tominaga, T., Meng, W., Togashi, K., Urano, H., Alberts, A. S., Tominaga, M. (2002). The Rho GTPase effector protein, mDia, inhibits the DNA binding ability of the transcription factor Pax6 and changes the pattern of neurite extension in cerebellar granule cells through its binding to Pax6. J Biol Chem 277, 47686-47691
    Ariga, K., Miyamoto, S., Nakase, T., Okuda, S., Meng, W., Yonenobu, K., Yoshikawa, H. (2001). The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc. Spine 26, 2414-2420
    Meng, W., Yonenobu, K., Ariga, K., Nakase, T., Okuda, S., Obata, K., Yoshikawa, H. (2001). Localization of cathepsins G and L in spontaneous resorption of intervertebral discs in a rat experimental model. J Musculoskelet Neuronal Interact 2, 171-176