--中国科学院遗传与发育生物学研究所

姓　　名：	李红菊
职　　称：	研究员
职　　务：
电话/传真：	010-64806901
电子邮件：	hjli@genetics.ac.cn
实验室主页：
研究方向：	植物发育生物学

简历介绍：

李红菊，博士，研究员，博士生导师，课题组组长

2004年获河北师范大学学士学位，2010年获中国科学院遗传发育所博士学位。2010-2016年，在遗传发育所任助理研究员、副研究员。2017-至今，研究员。2016年获 “国家优秀青年基金”资助，2024年获“国家杰出青年基金”资助，2018年入选中国科学院青促会优秀会员，2024年获“卫志明青年创新奖”。任Seed Biology编委、中国植物学会理事、植物结构与生殖生物学专业委员会主任。

研究领域：

课题组主要研究植物有性生殖发育的分子调控，以模式植物拟南芥、水稻和豆科植物为材料，重点解析花发育、传粉受精及种子发育启动的分子调控机理，以及发育程序与环境的互作机制。

1.挖掘关键基因，探究其在单双子叶植物生殖效率和杂交育种中的应用，探索杂交技术新策略，以促进种间优良基因重组，创制新物种和新种质、拓展杂种优势利用范围。

2.解析种子发育的分子调控机理，建立种子改良、单倍体诱导和无融合生殖技术体系，服务杂交育种和制种。

3.解析植物发育与环境之间的互作机制，探索环境智能型植物新理论。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

(*Co-first author; #Co-corresponding author)

1. Cao MX*, Li SZ*, and Li HJ. (2024). MpMLO1 controls sperm discharge in liverwort. Nature Plants 10: 1027–1038.

2. Meng JG, Li SZ, and Li HJ. (2024). Central cell: the key to determine persistent pollen tube attraction or termination. Science China Life Sciences 67:2030-2032.

3. Xu YJ*, Luo T*, Zhou PM*, Wang WQ, Yang WC, Li HJ. (2024). Pollen-expressed RLCKs control pollen tube burst. Plant Communications 5:100934.

4. Wang WQ*, Meng JG*, Yang F, Xu YJ, Li, SZ, and Li HJ. (2024). A non-defensin peptide NPA1 attracts pollen tube in Arabidopsis. Seed Biology 3: e003.

5. Zhong S*, Zhao P*, Peng X*, Li HJ*, Duan Q*, Cheung AY. (2024). From gametes to zygote: mechanistic advances and emerging possibilities in plant reproduction. Plant Physiology 195:4-35.

6. Meng JG*, Xu YJ*, Wang WQ*, Yang F*, Chen SY, Jia PF, Yang WC, and Li HJ (2023) Central cell-produced attractants control fertilization recovery. Cell 186:1-13.

7. Wang J, Wang XF, Yang WC#, and Li HJ# (2023) Loss of function of CENH3 causes genome instability in soybean. Seed Biology 2: 24.

8. Li S, Wang J, Jia S, Wang K# and Li HJ# (2023) Synthetic apomixis: from genetic basis to agricultural application. Seed Biology 2: 10.

9. Chen SY, Wang L, Jia PF, Yang WC, Sze H, and Li HJ (2022) Osmoregulation determines sperm cell geometry and integrity for double fertilization in flowering plants. Molecular Plant 15: 1488–1496.

10. Xue Y*, Meng JG*, Jia PF, Zhang ZR, Li HJ# and Yang WC# (2022) POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis. Nature Communications 13: 2703.

11. Xue Y, Jia PF, Li HJ (2022) SUN3/4/5 proteins regulate endoplasmic reticulum tubule formation and luminal spacing in Arabidopsis. Journal of Genetics and Genomics 50: 370-373.

12. Luo Y, Shi DQ, Jia, PF, Bao Y, Li HJ, Yang WC (2021) Nucleolar histone deacetylases HDT1, HDT2 and HDT3 regulate plant reproductive development. Journal of Genetics and Genomics 49:30-39.

13. Li HJ#, Yang WC# (2020) Central cell in flowering plants: specification, signaling, and evolution. Frontiers Plant Science 11: 590307.

14. Chen W, Jia PF, Yang WC#, Li HJ# (2020) Plasma membrane H⁺-ATPases-mediated cytosolic proton gradient regulates pollen tube growth. Journal of Integrative Plant Biology 62: 1817-1822.

15. Zhang MX#, Zhu SS#, YC, Guo YL, Yang WC#, Li HJ# (2020) Transcriptional repression specifies the central cell for double fertilization. Proc Natl Acad Sci U S A117: 6231-6236.

16. Meng JG#, Liang L#, Jia PF, Wang YC, Li HJ#, Yang WC# (2020) Integration of ovular signals and exocytosis of a Ca²⁺ channel by MLOs in pollen tube guidance. Nature Plants 6: 143-153.

17. Meng JG, Zhang MX, Yang WC#, Li HJ# (2019) TICKET attracts pollen tubes and mediates reproductive isolation between relative species in Brassicaceae. Science China Life Sciences 62: 1413-1419.

18. Shi C, Luo P, Du YT, Chen H, Huang X, Cheng TH, Luo A, Li HJ, Yang WC, Zhao P, Sun MX (2019) Maternal control of suspensor programmed cell death via gibberellin signaling. Nature Communications 10: 3484.

19. Jia PF*, Xue Y*, Li HJ#, Yang WC# (2018) Golgi-localized LOT regulates trans-Golgi network biogenesis and pollen tube growth. Proc Natl Acad Sci U S A 115: 12307-12312.

20. Li HJ#, Meng JG, Yang WC# (2018) Multilayered signaling pathways for pollen tube growth and guidance. Plant Reproduction 31: 31-41.

21. Li HJ#, Yang WC# (2018) Ligands switch model for pollen-tube integrity and burst. Trends in Plant Science 23: 369-372.

22. Yuan GL, Li HJ#, Yang WC# (2017) The integration of Gβ and MAPK signaling cascade in zygote development. Scientific Reports 7: 8732.

23. Jia PF, Li HJ, Yang WC (2017) Analysis of peroxisome biogenesis in pollen by confocal microscopy and transmission electron microscopy. Methods in Molecular Biology 1669:173-180. Springer.

24. Jia PF, Li HJ, Yang WC (2017) Transmission electron microscopy (TEM) to study histology of pollen and pollen tubes. Methods in Molecular Biology 1669:181-189. Springer.

25. Wang T, Liang L, Yong X, Jia PF, Chen W, Zhang MX, Wang YC, Li HJ#, Yang WC# (2016) A receptor heteromer mediates the male perception of female attractants in plants. Nature 531: 241-244.

26. Li HJ#, Yang WC# (2016) RLKs orchestrate the signaling in plant male-female interaction. Science China Life Sciences 59: 867-877.

27. Wang JG, Feng C, Liu HH, Ge FR, Li S, Li HJ, Zhang Y (2016) HAPLESS13-mediated trafficking of STRUBBELIG is critical for ovule development in Arabidopsis. PLoS Genetics 12: e1006269.

28. Yu TY, Shi DQ, Jia PF, Tang J, Li HJ, Liu J, Yang WC (2016). The Arabidopsis receptor kinase ZAR1 is required for zygote asymmetric division and its daughter cell fate. PLoS Genetics 12: 0-e1005933.

29. Wang J*, Li HJ*, Han Z, Zhang H, Wang T, Lin G, Chang J, Yang WC#, Chai J# (2015) Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525: 265-268.

30. Li HJ*, Zhu SS*, Zhang MX*, Wang T, Liang L, Xue Y, Shi DQ, Liu J, Yang WC (2015) Arabidopsis CBP1 is a novel regulator of transcription initiation in central cell-mediated pollen tube guidance. Plant Cell 27: 2880-2893.

31. Yan L, Wei S, Wu Y, Hu R, Li HJ, Yang W, Qi Xie (2015) High efficiency genome editing in Arabidopsis using Yao promoter-driven CRISPR/Cas9 system. Molecular Plant 1823: 1820-1823.

32. Li XR*, Li HJ*, Yuan L*, Liu M, Shi DQ, Liu J, Yang WC (2014) Arabidopsis DAYU/ABERRANT PEROXISOME MORPHOLOGY9 is a key regulator of peroxisome biogenesis and plays critical roles during pollen maturation and germination in planta. Plant Cell 26: 619-635.

33. Li HJ, Yang WC (2012) Emerging role of ER quality control in plant cell signal perception. Protein Cell 3: 10-16.

34. Li HJ, Xue Y, Jia DJ, Wang T, Shi DQ, Liu J, Cui F, Xie Q, Ye D, Yang WC (2011) POD1 regulates pollen tube guidance in response to micropylar female signaling and acts in early embryo patterning in Arabidopsis. Plant Cell 23: 3288-3302.

35. Li HJ*, Liu NY*, Shi DQ, Liu J, Yang WC (2010) YAO is a nucleolar WD40-repeat protein critical for embryogenesis and gametogenesis in Arabidopsis. BMC Plant Biology 10: 169.

36. Chen YH, Li HJ, Shi DQ, Yuan L, Liu J, Sreenivasan R, Baskar R, Grossniklaus U, Yang WC (2007) The central cell plays a critical role in pollen tube guidance in Arabidopsis. Plant Cell 19: 3563-3577.