--中国科学院遗传与发育生物学研究所

姓　　名：	冯健
职　　称：	研究员
职　　务：
电话/传真：	86-10-64807534
电子邮件：	jfeng@genetics.ac.cn
实验室主页：
研究方向：	植物与固氮微生物共生互作的分子机理

简历介绍：

冯健，博士，研究员，博士生导师

2001-2005年，南开大学，本科

2005-2013年，中国科学院遗传与发育生物学研究所，博士

2013-2017年，英国John Innes Centre，博士后

2017-2022年，英国剑桥大学Sainsbury Laboratory，博士后

2022年 - 今，中国科学院遗传与发育生物学研究所，研究员

2022年 - 今，中国科学院-英国约翰英纳斯中心植物和微生物科学联合研究中心(CEPAMS)，研究员

研究领域：

生物固氮是指微生物在固氮酶的作用下将空气中的氮气还原为氨的过程。改造利用生物固氮以减少农作物对工业氮肥的依赖对实现可持续农业发展和碳中和目标有着重要的意义。本课题组将围绕豆科植物-根瘤菌共生固氮的分子机理开展深入研究，以期揭示其中的精准调控机制，获得有重要价值的分子网络，为未来利用生物固氮替代化学氮肥以及作物精准设计育种提供理论基础。

1.解析豆科植物与根瘤菌共生固氮的分子机理

本课题组以豆科模式植物苜蓿、百脉根等为材料，利用分子遗传学、细胞生物学、基因组学和生物化学等手段，解析根瘤菌侵染植物、根瘤发生、类菌体中固氮微环境的建立与维持的分子机制；利用比较基因组学、系统生物学等手段了解豆科植物与根瘤菌共生固氮机制的进化规律。为未来改造生物固氮，创造能够自主固氮的粮食作物、蔬菜和水果提供理论依据。

2.分子设计辅助牧草育种

提高牧草固氮效率有利于推动农业减排，助力实现碳中和目标。本课题组以“牧草之王”苜蓿为研究材料，利用分子遗传学、基因组学和生物信息学等手段，对影响牧草固氮性状的调控网络进行解析，为牧草分子设计育种提供理论基础。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

期刊论文

1.Feng, J., Lee, T., Schiessl, K., Oldroyd, G. (2021). Processing of NODULE INCEPTION controls the transition to nitrogen fixation in root nodules. Science, 2021, 374 6567): 629-632

2.Chen, L., Wu, R., Feng, J., Feng, T., Wang, C., Hu, J., Zhan, N., Li, Y., Ma, X., Ren, B., Zhang, J., Song, C,-P., Li, J., Zhou, J.-M., and Zuo, J. (2020). Transnitrosylation mediated by the non-canonical catalase ROG1 regulates nitric oxide signaling in plants. Dev Cell, 2020, 53(4): 444-457.e5

3.Feng, J., Chen, L., and Zuo, J. (2019) Protein S-nitrosylation in plants: Current progresses and challenges. J Integr Plant Biol, 2019, 61(12): 1206-1223

4.Zhan, N.^*, Wang, C.^*, Chen, L., Yang, H., Feng, J., Gong, X., Ren, B., Wu, R., Mu, J., Li, Y., Liu, Z., Zhou, Y., Peng, J., Wang, K., Huang, X., Xiao, S., and Zuo, J. (2018). S-Nitrosylation targets GSNO reductase for selective autophagy during hypoxia responses in plants. Mol Cell, 71:142-154 (^* These authors contributed equally)

5.Wang, Q.^*, Nian, J.^*, Xie, X.^*, Yu, H., Zhang, J., Bai, J., Dong, G., Hu, J., Bai, B., Chen, L., Xie, Q., Feng, J., Yang, X., Peng, J., Chen, F., Qian, Q., Li, J., Zuo, J. (2018). Genetic variations in ARE1 mediate grain yield by modulating nitrogen utilization in rice. Nat Commun 9: 735. (^* These authors contributed equally)

6.Yang, X.^*, Nian, J.^*, Xie, Q., Feng, J., Zhang, F., Jing, H., Zhang, J., Dong, G., Liang, Y., Peng, J., Wang, G., Qian, Q., Zuo, J. (2016). Rice ferredoxin-dependent glutamate synthase regulates nitrogen-carbon metabolomes and is genetically differentiated between japonica and indica subspecies. Mol Plant, 9: 1520-1534. (^* These authors contributed equally)

7.Zhao, W., Guan, C., Feng, J., Liang, Y., Zhan, N., Zuo, J., and Ren, B. (2016) The Arabidopsis CROWDED NUCLEI genes regulate seed germination by modulating degradation of ABI5 protein. J Integr Plant Biol, 58: 669-678.

8.Jing, H.^*, Yang, X.^*, Zhang, J., Liu, X., Zheng, H., Dong, G., Nian, J., Feng, J., Xia, B., Qian, Q., Li, J., and Zuo, J. (2015) Peptidyl-prolyl isomerization targets rice Aux/IAAs for degradation during auxin signaling. Nat Commun, 6:7395. (^* These authors contributed equally)

9.Yang, H.^*, Mu, J.^*, Chen, L., Feng, J., Hu, J., Li, L.,Zhou, J.-M., and Zuo, J (2015). S-nitrosylation positively regulates ascorbate peroxidase activity during plant stress responses. Plant Physiol, 167: 1604-1615. (^* These authors contributed equally)

10.Guan, C., Wang, X., Feng, J., Hong, S., Liang, Y., Ren, B., and Zuo, J. (2014). Cytokinin antagonizes abscisic acid-mediated inhibition of cotyledon greening by promoting the degradation of ABI5 protein in Arabidopsis. Plant Physiol, 164: 1515-1526.

11.Ren, B.^*, Chen, Q.^*, Hong, S., Zhao, W., Feng, J., Feng, H., and Zuo, J. (2013) The Arabidopsis eukaryotic translation initiation factor eIF5A-2 regulates root protoxylem development by modulating cytokinin signaling. Plant Cell. 25: 3841-3857. (^* These authors contributed equally)

12.Feng, J., Wang, C., Chen, Q., Chen, H., Ren, B., Li, X., and Zuo, J. (2013) S-nitrosylation of phosphotransfer proteins represses cytokinin signaling. Nat Commun. 4: 1529.7.

13.Feng, H., Chen, Q., Feng, J., Zhang, J, Yang, X., and Zuo, J. (2007) Functional characterization of the Arabidopsis eukaryotic translation initiation factor 5A-2 (eIF-5A-2) that plays a crucial role in plant growth and development by regulating cell division, cell growth and cell death. Plant Physiol. 144: 1531-1545.

14. 陈立超^* 詹妮^* 李彦莎冯健左建儒. (2019) 植物蛋白质S-亚硝基化修饰的检测与分析. 植物学报 54: 497-502. (^* 同等贡献)

学术专著

1.Feng, J., Shi, Y., Yang, S., and Zuo, J. Chapter 3-Cytokinins, In Hormone Metabolism and Signaling in Plants, edited by Li, J., Li, C., and Smith, SM, Academic Press, 2017, Pages 77-106, ISBN 9780128115626

2.任勃^* 王兴春^* 冯健^* 杨淑华左建儒 (2012) 细胞分裂素 (pp. 40-64, 许智宏薛红卫主编《植物激素作用的分子机理》)，上海科学出版社. (^* 同等贡献)