--中国科学院遗传与发育生物学研究所

姓　　名：	张春霞
职　　称：	研究员
职　　务：
电话/传真：
电子邮件：	cxzhang@genetics.ac.cn
实验室主页：
研究方向：	发育和疾病中细胞命运转变的系统性研究

简历介绍：

张春霞，博士，研究员，博士生导师

2010年于东北林业大学获学士学位，2017年于中国科学院动物研究所获博士学位，毕业论文入选“中国科学院优秀博士学位论文”。2017年-2022年在哈佛医学院/波士顿儿童医院进行博士后研究。2023年加入中国科学院遗传与发育生物学研究所，任分子系统生物学研究中心研究员。

研究领域：

实验室主要对早期胚胎发育和疾病中细胞命运转变的调控机制进行系统性研究。以小鼠为模式动物，通过高通量多组学测序技术结合生物信息学分析，从多维度探索小鼠早期胚胎发育过程中细胞命运转变的调控机制，以及胚胎基因在疾病（如癌症）中的作用机理。包括：

1. 小鼠早期胚胎发育过程中转录和转录后的调控机制

随着精子和卵子的结合，两个终末分化的生殖细胞形成具有发育全能性的受精卵。在此过程中，细胞的表观修饰经历了大规模的重编程，而且母源mRNA逐渐被清除，合子基因组被激活。由于胚胎在早期发育过程中经历了剧烈细胞命运转变，重编程调控网络必须精准运作才能保证胚胎正常发育，我们的研究目标是解析小鼠早期胚胎发育过程中表观遗传和转录后的调控机制。

2. 全能性干细胞的诱导和维持

全能细胞相比于其他细胞类型具有更强的发育潜能，能够产生胚胎和胚外组织。成功在体外诱导和维持与体内全能性胚胎相似的全能性干细胞，有助于利用体外细胞培养体系研究着床前胚胎发育过程，有助于在体外诱导分化胚外组织，最终获得可应用于再生医学的高质量细胞和器官。虽然目前已经有文章报道可以通过小分子抑制剂来诱导产生全能性干细胞，但其发育潜能远低于全能性胚胎。我们的研究目标是寻找能够在体外实现不依赖卵母细胞的体细胞向全能干细胞的诱导和维持的方法。

3. 研究胚胎基因激活在癌症发生发展中的作用

胚胎发生和癌症发生在细胞和分子水平上有许多相似之处，癌细胞通常也会表达与胚胎发育相关的基因。我们的研究目标是通过对早期胚胎发生和癌症发生过程进行全面系统性分析，探究全能性基因在肿瘤发生中激活的激活机制，及其激活在癌症发生发展中的作用，以期能够找到癌症治疗新靶点。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

KEY PUBLICATIONS（ ^# Co-first author，* Corresponding author）

1.Wang WL, Zhang CX*. (2023) Research progress on the study of transcriptome-wide poly(A) tails in mammalian oocytes and early embryos. Hereditas(Beijing), doi: 10.16288/j.yczz.23-047.

2.Zhang CX, Zhang Y. (2023) Start of life controlled by poly(A) tail-mediated remodeling. Trends Genet. doi: 10.1016/j.tig.2023.03.001.

3.Zhang CX^#, Wang M^#, Li Y^#, Zhang Y. (2022) Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition. Sci. Adv. 8(5):eabj3967.

4.Zhang CX, Liu F. (2021) Regulatory signaling pathways in hematopoietic stem cell development. Yi Chuan = Hereditas. 43(4):295-307.

5.Fu XD^#, Zhang CX^#, Zhang Y. (2020) Epigenetic regulation of mouse preimplantation embryo development. Curr. Opin. Genet. Dev. 64:13-20.

6.Zhang CX^#, Chen ZY^#, Yin QZ, Fu XD, Li YS, Stopka T, Skoultchi AI, Zhang Y. (2020) The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression. Genes Dev 34(3-4):166-178.

7.Chen ZY, Yin QZ, Inoue A, Zhang CX, Zhang Y. (2019) Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells. Sci. Adv. 5(12):eaay7246.

8.Djekidel MN, Inoue A, Matoba S, Suzuki T, Zhang CX, Lu FL, Jiang L, Zhang Y. (2018) Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. Cell Rep. 23(7):1939-1947.

9.Lv JH^#, Zhang YF^#, Gao SW^#, Zhang CX^#, Chen YS^#, Li W, Yang YG, Zhou Q, Liu F. (2018) Endothelial-specific m⁶A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling. Cell Res. 28(2):249-252.

10. Zhang CX and Liu F. (2018) RNA methylation regulates hematopoietic stem/progenitor cell specification. Sci China Life Sci. 61(5):610-612.

11. Yan HW^#, Zhang CX^#, Wang ZQ, Tu T, Duan HX, Luo YT, Feng J, Liu F, Yan X. (2017) CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Sci Rep. 7(1):7442

12. Zhang CX^#, Chen YS^#, Sun BF^#, Wang L^#, Yang Y^#, Ma DY, Lv JH, Heng J, Ding YY, Xue YY, Lu XY, Xiao W, Yang YG, Liu F. (2017) m⁶A modulates haematopoietic stem and progenitor cell specification. Nature 549(7671):273-276.

13. Xue YY, Lv JH, Zhang CX, Wang L, Ma DY, Liu F. (2017) The vascular niche regulates hematopoietic stem and progenitor cell lodgment and expansion via klf6a-ccl25b. Dev Cell. 42(4):349-362

14. Zhou WW, He QP, Zhang CX, He Xin, Cui ZB, Liu F, Li W. (2016) BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. Elife. e18108.

15. Hu MJ, Bai Y, Zhang CX, Liu F, Cui ZB, Chen J, Peng JR. (2016) Liver-enriched gene 1, a glycosylated secretory protein, binds to FGFR and mediates an anti-stress pathway to protect liver development in zebrafish. PLoS Genet. 12(2):e1005881.

16. Wang L, Zhang CX, Liu F. (2016) Molecular regulation of hematopoietic stem cell development. Scientia Sinica Vitae. 46(1):16-24.

17. Zhang PP, He QP, Chen DB, Liu WX, Wang L, Zhang CX, Ma DY, Li W, Liu B, Liu F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Res. 25:1093–1107.

18. He QP^#, Zhang CX^#, Wang L^#, Zhang PP, Ma DY, Lv JH, Liu F. (2015) Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood 125(7):1098-1106.

19. Tu T, Zhang CX, Yan H, Luo Y, Kong R, Wen P, Ye Z, Chen J, Feng J, Liu F, Wu JY, Yan X. (2015) CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res. 25(3):275-287.

20. Wei YL, Ma DY, Gao Y, Zhang CX, Wang L, Liu, F. (2014) Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood 124(10):1578-1585.

21. Zhang CX, Lv JH, He QP, Wang SF, G Ya, Meng AM, Yang X, Liu, F. (2014) Inhibition of endothelial ERK signaling by Smad1/5 is essential for hematopoietic stem cell emergence. Nat Commun. 5(3431).

22. Zhang CX, Patient R, Liu F. (2013) Hematopoietic stem cell development and regulatory signaling in zebrafish. Biochim Biophys Acta. 1830(2):2370-2374.

23. Ye ZD, Zhang CX, Tu T, Sun M, Liu D, Lu D, Feng J, Yang DL, Liu F and Yan XY. (2013) Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nat Commun. 4:2803.

24.Huang SJ^#, Zhang Z^#, Zhang CX^#, Lv XD^#, Zheng XD, Chen ZP, Sun LW, Wang HL, Zhu YX, Zhang J, Yang SY, Lu Y, Sun QM, Tao Y, Liu F, Zhao Y, Chen DH. (2013) Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. PLoS Biology (11) e1001721.