姓  名: 邓 娴
    职  称: 研究员
    职  务:
    电话/传真:
    电子邮件: xdeng@genetics.ac.cn
    实验室主页:
    研究方向: 植物表观遗传调控与耐逆饲草种质创新

    简历介绍:

    邓娴,博士,研究员
        长期致力于植物表观遗传调控机制研究,以第一作者或通讯作者身份在PNASNature PlantsNature CommunicationsCell ResearchNational Science Review等国际学术刊物上发表论文20余篇。曾获北京市科学技术二等奖,2022年入选中国科学院青年创新促进会优秀会员。主持多项国家级与院级科研项目,包括国家自然科学基金项目、中国科学院战略性先导专项和盐碱地重大科技专项等。
    教育经历:
        2001 - 2005,哈尔滨工业大学,学士
        2005 - 2007,哈尔滨工业大学,硕士
        2007 - 2011,中国科学院遗传与发育生物学研究所,博士
    工作经历:
        2011 – 2013,中国科学院遗传与发育生物学研究所,博士后
        2013 – 2017,中国科学院遗传与发育生物学研究所,助理研究员
        2018 – 2021,中国科学院遗传与发育生物学研究所,副研究员
        2025 –       ,中国科学院遗传与发育生物学研究所,研究员

    研究领域:

    研究领域:
        主要从事植物表观遗传调控与豆科饲草种质创新利用研究,具体如下:
        1. 植物表观遗传调控机制研究
        以拟南芥组蛋白去甲基化酶为研究对象,综合利用遗传学、生化与分子生物学、表观基因组学及单细胞组学等手段,系统揭示组蛋白去甲基化酶在植物发育可塑性与环境适应性中的表观遗传调控机制。
        2. 豆科饲草耐逆适生机制研究
        以耐逆豆科饲草田菁为核心材料,建立多维度耐逆筛选体系,整合多组学技术和人工智能方法,挖掘耐逆关键基因,解析其经典遗传与表观遗传调控网络,为饲草分子育种提供重要的基因资源。
        3. 豆科饲草饲用功能改良与利用
        聚焦田菁饲用价值优化与边际土地资源化利用。借助基因编辑等技术加速田菁新种质驯化与创制;优化田菁加工收储工艺,开展规模化种植与饲用价值评估,实现边际土地地力提升与生态、经济价值双赢。

    社会任职:

    获奖及荣誉:

    承担科研项目情况:

    代表论著:

    代表论著:
    1.  YanY#, Zhu J#, Qiu Q, Li J, Cao X* and Deng X*. (2025) The Arabidopsis demethylase REF6 physically interacts with phyB to promote hypocotyl elongation under red light. PNAS. 122(11): e2417253122.

    2.  HuangG#*, Wang X#, Liu C#, He K#, Hou X, Luo H, Zhang S, You C, Jia Y, Wang F, Song X, Liu G*, Deng X* and Cao X*. (2025) Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience inSesbania bispinosa. Advanced Science. 12(32):e02600.

    3.  Yin T, Song S, Song X, Pan D, Zhao Q, He L, Tang D, Jia Y, Cao X, Deng X* and Zhang W*. (2025) Effects of Adding Lactobacillus Inoculants on the Nutritional Value of Sesbania cannabina and Whole Corn Mixed Silage. Agriculture. 15(18), 1913.

    4.  Yan Y#, Luo H#, Qin Y#, Yan T, Jia J, Hou Y, Liu Z, Zhai J, Long Y*, Deng X*, and Cao X*. (2024) Light controls mesophyll-specific post-transcriptional splicing of photoregulatory genes by AtPRMT5. PNAS. 121: e2317408121.

    5.  Zhu J, Cao X*, and Deng X*. (2023) Epigenetic and transcription factors synergistically promote the high temperature response in plants. Trends in Biochemical Sciences. 48 (9): 788–800.

    6.  Mo W#, Shu Y#, Liu B, Long Y, Li T, Cao X, Deng X*, and Jixian Zhai*. (2023) Single-molecule targeted accessibility and methylation sequencing of centromeres, telomeres and rDNAs in Arabidopsis. Nature Plants. 9(9): 1439–1450.

    7.  Deng X*, Li T, Cao X*. (2023) Application and Prospect of Gene Editing in Forage Grass Breeding. Chinese Bulletin of Botany. 58(2): 233–240.

    8.  Deng X and Cao X*. Reconciliation between high yield and disease resistance (Research Highlight). Nature Reviews Genetics. 23: 262–263 (2022)

    9.  He K#, Mei H#, Zhu J, Qiu Q, Cao X*, and Deng X*. (2022) The Histone H3K27 demethylase REF6/JMJ12 promotes thermomorphogenesis in Arabidopsis. National Science Review. nwab213

    10.  Cao H, Liang Y, Zhang L, Liu Z, Liu D, Cao X, Deng X*, Jin Z*, Pei Y*. (2022) AtPRMT5-mediated AtLCD methylation improves Cd2+ tolerance via increased H2S production in Arabidopsis. Plant Physiology. 190(4): 2637–2650

    11.  He K, Cao X*, and Deng X*. Histone methylation in epigenetic regulation and temperature responses. Current Opinion in Plant Biology. 61: 102001 (2021)

    12.  Si F, Cao X, Song X*, and Deng X*. Processing of coding and non-coding RNAs in plant development and environmental responses. Essays in Biochemistry. 64: 931-945 (2020)

    13.  Qiu Q#, Mei H#, Deng X#, He K#, Wu B#, Yao Q, Zhang J, Lu F, Ma J*, and Cao X*. DNA methylation repels targeting of Arabidopsis REF6. Nature Communications. 10: 2063 (2019)

    14.  Liu J#, Feng L#, Gu X#, Deng X#, Qiu Q, Li Q, Zhang Y, Wang M, Deng Y, Wang E, He Y, Baurle I, Li J, Cao X*, and He Z*. An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis. Cell Research. 29: 379-390 (2019)

    15.  Deng X, Qiu Q, He K, and Cao X*. The seekers: how epigenetic modifying enzymes find their hidden genomic targets in Arabidopsis. Current Opinion in Plant Biology. 45: 75-81 (2018).

    16.  Deng X and Cao X*. Roles of pre-mRNA splicing and polyadenylation in plant development. Current Opinion in Plant Biology. 35: 45-53 (2017).

    17.  Deng X#, Lu T#, Wang L#, Gu L, Sun J, Kong X, Liu C*, and Cao X*. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Proceedings of the National Academy of Sciences of the United States of America. 113: 5447-5452 (2016).

    18.  Deng X, Song X, Wei L, Liu C, and Cao X*. Epigenetic regulation and epigenomic landscape in rice. National Science Review. 3: 309-327 (2016).

    19.  Hang R, Deng X*, Liu C, Mo B, and Cao X*. Circular RT-PCR assay using Arabidopsis samples. Bio-protocol. 5: e1533 (2015).

    20.  Deng X#, Gu L#, Liu C#, Lu T#, Lu F, Lu Z, Cui P, Pei Y, Wang B, Hu S, and Cao X*. Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 107: 19114-19119 (2010).