姓  名: 赵燕南
    职  称: 青年研究员
    职  务:
    电话/传真: 010-82614420
    电子邮件: ynzhao@genetics.ac.cn
    实验室主页:
    研究方向: 再生医学

    简历介绍:

    赵燕南,博士,青年研究员
            2016年入选中科院青年创新促进会会员,2020入选中科院青年创新促进会优秀会员。
    教育经历
            2000/9-2004/7 内蒙古大学,获学士学位
            2004/9-2010/7 中科院遗传发育所,获博士学位
    工作经历
            2010/07-2012/12 中科院遗传发育所,助理研究员
            2013/01-2020/12 中科院遗传发育所,副研究员
            2021/01-现在 中科院遗传发育所,青年研究员

    研究领域:

    研究内容
            研发脊髓损伤及心肌损伤修复生物材料产品。具体包括:医用胶原支架及水凝胶材料、靶向蛋白药物智能释放、干细胞三维培养及体内递送、组织类器官体外构建等。

    社会任职:

    获奖及荣誉:

    承担科研项目情况:

    代表论著:

    发表文章
    1.  Xue X, Wu X, Fan Y, Han S, Zhang H, Sun Y, Yin Y, Yin M, Chen B, Sun Z, Zhao S, Zhang Q, Liu W, Zhang J, Li J, Shi Y, Xiao Z*, Dai J*, Zhao Y*. Heterogeneous fibroblasts contribute to fibrotic scar formation after spinal cord injury in mice and monkeys. Nature Communications. 2024. 15: 6321
    2.  Sun Z, Chen Z, Yin M, Wu X, Guo B, Cheng X, Quan R, Sun Y, Zhang Q, Fan Y, Jin C, Yin Y, Hou X, Liu W, Shu M, Xue X, Shi Y, Chen B, Xiao Z, Dai J*, Zhao Y*. Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids. Cell Stem Cell. 2024. 31: 772-787
    3.  Guo B, Zhao X, Zou Y, Cheng X, Sun Z, Xue X, Yin M, Jin C, Chen Z, Quan R, Liu W, Chen B, Xiao Z, Zhao Y*, Gu R*, Dai J*. Evaluation of benefits and risks of immunosuppressive drugs in biomaterial-based neural progenitor cell transplantation for spinal cord injury repair. Chemical Engineering Journal. 2024. 487:150404
    4.  Sun Y, Xiao Z, Chen B, Zhao Y*, Dai J*. Advances in Material-Assisted Electromagnetic Neural Stimulation. Advanced Materials. 2024. 2400346
    5.  Fan C, Cai H, Zhang L, Wu X, Yan J, Jin L, Hu B, He J, Chen Y*, Zhao Y*, Dai J*. Constructing Linear-Oriented Pre-Vascularized Human Spinal Cord Tissues for Spinal Cord Injury Repair. Advanced Healthcare Materials. 2024. 2303388
    6.  Fan Y, Wu X, Han S, Zhang Q, Sun Z, Chen B, Xue X, Zhang H, Chen Z, Yin M, Xiao Z*, Zhao Y*, Dai J*. Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury. Nature Communications. 2023. 14: 4796
    7.  Chen Z, Sun Z, Fan Y, Yin M, Jin C, Guo B, Yin Y, Quan R, Zhao S, Han S, Cheng X, Liu W, Chen B, Xiao Z, Dai J*, Zhao Y*. Mimicked Spinal Cord Fibers Trigger Axonal Regeneration and Remyelination after Injury. ACS Nano. 2023. 17: 25591-25613
    8.  Cui Y, Liu W, Zhao S, Zhao Y*, Dai J*. Advances in Microgravity Directed Tissue Engineering. Advanced Healthcare Materials. 2023. 12: 2202768
    9.  Xu B, Liu D, Liu W, Long G, Liu W, Wu Y, He X, Shen Y, Jiang P, Yin M, Fan Y, Shen H, Shi L, Zhang Q, Xue W, Jin C, Chen Z, Chen B, Li J, Hu Y, Li X*, Xiao Z*, Zhao Y*, Dai J*. Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys. Bioactive Materials. 2023. 27: 125-137
    10.  Jin C, Wu Y, Zhang H, Xu B, Liu W, Ji C, Li P, Chen Z, Chen B, Li J, Wu X, Jiang P, Hu Y, Xiao Z*, Zhao Y*, Dai J*. Spinal cord tissue engineering using human primary neural progenitor cells and astrocytes. Bioengineering & Translational Medicine. 2023. 8: e10448
    11.  Xu B, Yin M, Yang Y, Zou Y, Liu W, Qiao L, Zhang J, Wang Z, Wu Y, Shen H, Sun M, Liu W, Xue W, Fan Y, Zhang Q, Chen B, Wu X, Shi Y, Lu F*, Zhao Y*. Xiao Z*, Dai J*. Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat. Bioactive Materials. 2023. 23: 300-313
    12.  Liu W, Xu B, Zhao S, Han S, Quan R, Liu W, Ji C, Chen B, Xiao Z, Yin M, Yin Y, Dai J*, Zhao Y*, Spinal cord tissue engineering via covalent interaction between biomaterials and cells. Science Advances. 2023. 9: eade8829
    13.  Fan C, Yang W, Zhang L, Cai H, Zhuang Y, Chen Y*, Zhao Y*, Dai J*. Restoration of spinal cord biophysical microenvironment for enhancing tissue repair by injury-responsive smart hydrogel. Biomaterials. 2022. 121689
    14.  Shen H, Fan C, You Z, Xiao Z, Zhao Y*, Dai J*. Advances in Biomaterial-Based Spinal Cord Injury Repair. Advanced Functional Materials. 2022. 32: 2110628
    15.  Chen Z, Zhang H, Fan C, Zhuang Y, Yang W, Chen Y, Shen H, Xiao Z, Zhao Y*, Li X*, Dai J*. Adhesive, Stretchable, and Spatiotemporal Delivery Fibrous Hydrogels Harness Endogenous Neural Stem/Progenitor Cells for Spinal Cord Injury Repair. ACS Nano. 2022. 16: 1986-1998
    16.  Jin X, Liu W, Wang J, Xiao Z, Niu Y, Chen B, Zhao Y*, Dai J*. Clinical study of injectable collagen scaffold with autologous fat cells for repair of severe vocal fold injury. Biomedical Materials. 2022.17: 035004
    17.  Tang F#, Tang J#, Zhao Y#, Zhang J#, Xiao Z, Chen B, Han G, Yin N, Jiang X, Zhao C, Cheng S, Wang Z, Chen Y, Chen Q, Song K, Wang Z, Niu J, Wang L, Shi Q, Chen L, Yang H, Hou S*, Zhang S*, Dai J*. Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold. Science China Life Science. 2022. 65: 909-926
    18.  Wang Q#, He X#, Wang B, Pan J, Shi C, Li J, Wang L, Zhao Y*, Dai J*, Wang D*, Injectable collagen scaffold promotes swine myocardial infarction recovery by long-term local retention of transplanted human umbilical cord mesenchymal stem cells. Science China Life Science. 2021; Feb;64(2):269-281
    19.  He X#, Wang Q#, Zhao Y#, Zhang H, Wang B, Pan J, Li J, Yu H, Wang L, Dai J*,Wang D*. Effect of intramyocardial grafting collagen scaffold with mesenchymal stromal cells in patients with chronic ischemic heart disease: A Randomized Clinical Trial. JAMA Network Open. 2020;3(9):e2016236. doi:10.1001/jamanetworkopen.2020.16236
    20.  Liu W, Xu B, Xue W, Yang B; Fan Y; Chen B, Xiao Z, Xue X, Sun Z, Shu M, Zhang Q, Shi Y, Zhao Y*, Dai J*. A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair, Biomaterials. 2020,243:119941.
    21.  Shi J#, Fan C#, Zhuang Y, Sun J, Hou X, Chen B, Xiao Z, Chen Y, Zhan Z, Zhao Y*, Dai J*. Heparan sulfate proteoglycan promotes fibroblast growth factor-2 function for ischemic heart repair. Biomaterials Science. 7(12):5438-5450. 
    22.  Fan C#, Shi J#, Zhuang Y, Zhang L, Huang L, Yang W, Chen B, Chen Y, Xiao Z, Shen H, Zhao Y*, Dai J*. Myocardial-Infarction-Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery. Advanced Materials. 2019 Oct;31(40):e1902900.
    23.  Shi C#, Zhao Y#, Yang Y, Chen C, Hou X, Shao J, Yao H, Li Q, Xia Y, Dai J*. Collagen-binding VEGF targeting the cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction. Biomaterials Science. 2018. 30;6(2):356-363
    24.  Xiao Z#, Tang F#, Zhao Y#, Han G, Yin N, Li X, Chen B, Han S, Jiang X, Yun C, Zhao C, Cheng S, Zhang S*, Dai J*. Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with NeuroRegen Scaffolds and Mesenchymal Stem Cells. Cell Transplantation. 2018. 27(6):907-915
    25.  Chen X#, Zhao Y#, Li X, Xiao Z, Yao Y, Chu Y, Farkas B, Romano I, Brandi F, Dai J*. Functional Multichannel Poly(Propylene Fumarate)-Collagen Scaffold with Collagen-Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury. Advanced Healthcare Materials. 2018. 7(14):e1800315.
    26.  Shi L#, Zhao Y#, Xie Q, Fan C, Hilborn J, Dai J*, Ossipov DA*. Moldable Hyaluronan Hydrogel Enabled by Dynamic Metal-Bisphosphonate Coordination Chemistry for Wound Healing. Advanced Healthcare Materials. 2018 Mar;7(5). doi: 10.1002/adhm.201700973. 
    27.  Chen B#, Xiao Z#Zhao Y#,Dai J*. Functional biomaterial-based regenerative microenvironment for spinal cord injury repair. National Science Review. 2017. 4(4) 530-532
    28.  Li X#, Zhao Y#, Cheng S#, Han S, Shu M, Chen B, Chen X, Tang F, Wang N, Tu Y, Wang B, Xiao Z, Zhang S, Dai J. Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair. Biomaterials. 2017. 137:73-86.
    29.  Zhao Y#, Tang F#, Xiao Z#, Han G, Wang N, Yin N, Chen B, Jiang X, Yun C, Han W, Zhao C, Cheng S, Zhang S*, Dai J*. Clinical Study of NeuroRegen Scaffold Combined with Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury. Cell Transplant. 2017. 26(5):891-900.
    30.  Li X#, Liu S#, Zhao Y#, Li J, Ding W, Han S, Chen B, Xiao Z, Dai J*. Training Neural Stem Cells on Functional Collagen Scaffolds for Severe Spinal Cord Injury Repair. Advanced Functional Materials. 2016. 26(32):5835-5847
    31.  Zhang J#, Zhao Y#, Hou X, Chen B, Xiao Z, Han J, Shi C, Liu J, Miao Q, Dai J*. The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. Biomaterials. 2014. 35(34):9322-31.
    32.  Su G#, Zhao Y#, Wei J#, Han J, Chen L, Xiao Z, Chen B, Dai J*. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials. 2013. 34(13):3215-22. 
    33.  Su G#, Zhao Y#, Wei J#, Xiao Z, Chen B, Han J, Chen L, Guan J, Wang R, Dong Q, Dai J*. The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials. 2013. 34(13):3215-3222.
    34.  Han S#, Zhao Y#, Xiao Z, Han J, Chen B, Chen L, Dai J*. The three-dimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. Journal of Genetics and Genomics. 2012. 39(12):633-41.
    35.  Shi C#, Li Q#, Zhao Y#, Chen W, Chen B, Xiao Z, Lin H, Nie L, Wang D* and Dai J*.(2011) Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration. Biomaterials. 2011. 32(10):2508-2515
    36.  He Q#, Zhao Y#, Chen B, Xiao Z, Zhang J, Chen L, Chen W, Deng F and Dai J*. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomaterialia. 2011. 7:1084-1093.
    37.  Zhao Y#, Zhang J#, Wang X ,Chen B, Xiao Z,Shi C, Wei Z,Hou X,Wang Q and Dai J*. The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies. Journal of Controlled Release. 2010. 141(1):30-37
    38.  Zhang J#, Ding L#, Zhao Y#, Sun W, Chen B, Lin H, Wang X , Zhang L, Xu B* and Dai J*.  Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 2009. 119(13):1776-1784.
    39.  Zhao Y#, Lin H#, Zhang J, Chen B, Sun W, Wang X, Zhao W, Xiao Z and Dai J*. Crosslinked Three-Dimensional Demineralized Bone Matrix for the Adipose-Derived Stromal Cell Proliferation and Differentiation. Tissue Engineering: Part A. 2009. 15(1): 13-21
    40.  Yang Y#, Zhao Y#, Chen B, Han Q, Sun W, Xiao Z and Dai J*. Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds. Tissue Engineering: Part A. 2009. 15(11):3589-3596.
    41.  Zhao Y#, Chen B#, Lin H, Sun W, Zhao W, Zhang J and Dai J*. The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2. Journal of Biomedical Materials Research Part A, 2009. 88(3): 725-734.
    42.  Lin H#, Zhao Y#, Sun W#, Chen B, Zhang J, Zhao W, Xiao Z and Dai J*. The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2. Biomaterials. 2008. 29(9):1189-1197.