近期代表性论文:
Li QY, Qin L, Tang LH, Zhang CR, Huang S, Wang K, Zhang GH, Hao NJ, Xiao Q, Niu T, Su M, Hedrich R, Chen YH. Structural and mechanistic insights into symmetry conversion in plant GORK K+ channel regulation. Protein Cell. 2025 Aug 3:pwaf067. doi: 10.1093/procel/pwaf067. Epub ahead of print. PMID: 40996076.
Lu P, Zhang G, Li J, Gong Z, Wang G, Dong L, Zhang H, Guo G, Su M, Wang K, Wang Y, Zhu K, Wu Q, Chen Y, Li M, Huang B, Li B, Li W, Dong L, Hou Y, Cui X, Fu H, Qiu D, Yuan C, Li H, Zhou JM, Han GZ, Chen Y, Liu Z. A wheat tandem kinase and NLR pair confers resistance to multiple fungal pathogens. Science. 2025 Mar 28;387(6741):1418-1424. doi: 10.1126/science.adp5469IF: 45.8 Q1 . Epub 2025 Mar 27. PMID: 40146830.
Lu X, Li D, Wang Y, Zhang G, Wen T, Lu Y, Jia N, Wang X, Chang S, Zhang X, Lin J, Chen YH, Yang X, Shen Y. Structural insights into the activation mechanism of the human zinc-activated channel. Nat Commun. 2025 Jan 7;16(1):442. doi: 10.1038/s41467-024-55807-5. PMID: 39774710; PMCID: PMC11707272.
Tang S, Shi J, Li X, Yang M, Li C, Zhang D, Yang S, Mei C, Luo Z, Zhang L, Zhang W, Zhang C, Zhu C, Ma X, Xia R, Chen Y, Zhang J, Chen Q, Chen S, Xie Q, Yu F. Development and Breeding of Herbicide-Resistant Sorghum for Effective Cereal-Legume Intercropping. Adv Sci (Weinh). 2025 Jul;12(27):e2503083. doi: 10.1002/advs.202503083IF: 14.1 Q1 . Epub 2025 May 8. PMID: 40344633; PMCID: PMC12279207.
Ban X, Qin L, Yan J, Wu J, Li Q, Su X, Hao Y, Hu Q, Kou L, Yan Z, Xin P, Zhang Y, Dong L, Bouwmeester H, Yu H, Yu Q, Huang S, Lin T, Xie Q, Chen Y, Chu J, Cui X, Li J, Wang B. Manipulation of a strigolactone transporter in tomato confers resistance to the parasitic weed broomrape. Innovation (Camb). 2025 Jan 29;6(3):100815. doi: 10.1016/j.xinn.2025.100815. PMID: 40098680; PMCID: PMC11910882.
Ma L, Qin DB, Sun L, Zhang K, Yu X, Dang AK, Hou S, Zhao X, Yang Y, Wang Y, Chen Y, Guo Y. SALT OVERLY SENSITIVE2 and AMMONIUM TRANSPORTER1;1 contribute to plant salt tolerance by maintaining ammonium uptake. Plant Cell. 2025 Feb 13;37(2):koaf034. doi: 10.1093/plcell/koaf034. PMID: 39963720; PMCID: PMC11840955.
Shi J, Mei C, Ge F, Hu Q, Ban X, Xia R, Xin P, Cheng S, Zhang G, Nie J, Zhang S, Ma X, Wang Y, Chu J, Chen Y, Wang B, Wu W, Li J, Xie Q, Yu F. Resistance to Striga parasitism through reduction of strigolactone exudation. Cell. 2025 Apr 3;188(7):1955-1966.e13. doi: 10.1016/j.cell.2025.01.022. Epub 2025 Feb 12. PMID: 39947180.
Guo G, Bai K, Hou Y, Gong Z, Zhang H, Wu Q, Lu P, Li M, Dong L, Xie J, Chen Y, Zhang P, Zhu K, Li B, Li W, Dong L, Yang Y, Qiu D, Wang G, Ahn HK, Zhao H, Yuan C, Shi W, Xue M, Yang L, Yu D, Zhao Y, Chen Y, Li H, Hu T, Han GZ, Jones JDG, Liu Z. The wheat NLR pair RXL/Pm5e confers resistance to powdery mildew. Plant Biotechnol J. 2025 Apr;23(4):1260-1276. doi: 10.1111/pbi.14584. Epub 2025 Jan 22. PMID: 39840722; PMCID: PMC11933841.
Li Qin, Ya-nan Deng, Xiang-yun Zhang, Ling-hui Tang, Chun-rui Zhang, Shi-min Xu, Ke Wang, Mei-hua Wang, Xian-hui Zhang, Min Su, Qi Xie, Wayne A. Hendrickson, Yu-hang Chen(2024). “Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling". PNAS 121(9)e2323040121
Xiang-yun Zhang,Ling-hui Tang, Jia-wei Nie, Chun-rui Zhang,Xiaonan Han, Qi-yu Li, Li Qin, Mei-hua Wang, Xiahe Huang, Feifei Yu,Min Su, Yingchun Wang, Rui-ming Xu, Yan Guo, Qi Xie,Yu-hang Chen (2023). "Structure and activation mechanism of the rice Salt Overly Sensitive 1(SOS1) Na+/H+ antiporter". Nature Plants 2023:9(11):1924-1936
Xiang-yun Zhang & Yu-hang Chen (2023) "Structural insight into SOS signalling in response to salt stress". Nature Plants 2023:9(11):1793-1794.
Wei Wang*, Li Qin, Wenjing Zhang, Linghui Tang, Chao Zhang, Xiaojing Dong, Pei Miao, Meng Shen, Huilong Du, Hangyuan Cheng, Ke Wang, Xiangyun Zhang, Min Su, Hongwei Lu, Chang Li, Qiang Gao, Xiaojuan Zhang, Yun Huang, Chengzhi Liang, Jian-Min Zhou*, and Yu-hang Chen* (2023) "Weitsing, A Pericycle-Expressed Ion Channel,Safeguards the Stele to Confer Clubroot Resistance" ,Cell 186,2656-2671
Zhou, Y., Zhang, T., Wang, X., Wu, W., Xing, J., Li, Z., Qiao, X., Zhang, C., Wang, X., Wang, G., Li, W., Bai, S., Li, Z., Suo, Y., Wang, J., Niu, Y., Zhang, J., Lan, C., Hu, Z., Li, B., Zhang, X., Wang, W., Galbraith, D.W., Chen, Y., Guo, S., and Song, C.P. (2023). "A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis". Nature Communications 14, 4384.
Alexander Forderer, Ertong Li, Aaron W. Lawson, Ya-nan Deng, Yue Sun,Elke Logemann, Xiaoxiao Zhang, Jie Wen, Zhifu Han, Junbiao Chang, Yuhang Chen*,Paul Schulze-Lefert* & Jijie Chai*.(2022)"A wheat resistosome defines common principles of immune receptor channels",Nature 610,532-539
Qin L, Tang LH, Xu JS, Zhang XH, Zhu Y, Zhang CR, Wang MH, Liu XL, Li F, Sun F, Su M*, Zhai Y*, Chen YH*. (2022) "Cryo-EM structure and electrophysiological characterization of ALMT from Glycine max reveal a previously uncharacterized class of anion channels", Science Advances 8(9): eabm3238.
Pei YR, Deng YN, Zhang HR, Zhang ZG, Liu J, Chen ZB, Cai DR, Li K, Du YM, Zang J, Xin PY, Chu JF, Chen YH, Zhao L, Liu J, Chen HB. (2022) " EAR APICAL DEGENERATION1 regulates maize ear development by maintaining malate supply for apical inflorescence", Plant Cell 16 March 2022
Dong Q, Liu XL, Wang XH, Zhao Y, Chen YH, Li F. (2021) "Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly", PNAS 118(48):e2104459118.
Ban H, Sun W, Chen YH, Chen Y, Li F. (2021) "Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation", Genetics 218(1):iyab032.
Bi GZ, Su M, Li N, Liang Y, Dang S, Xu JC, Hu MJ, Wang JZ, Zou MX, Deng YN, Li QY, Huang SJ, Li JJ, Chai JJ*, He KM*, Chen YH*, Zhou JM*. (2021) "The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling", Cell 184 (13): 3528-3541.e12
Deng YN, Kashtoh H., Wang Q, Zhen GX, Li QY, Tang LH, Gao HL, Zhang CR, Qin L, Su M, Li F, Huang XH, Wang YC, Xie Q, Clarke O.B. *, Hendrickson W.A.*, Chen YH*. (2021) "Structure and activity of SLAC1 channels for stomatal signaling in leaves", PNAS 118 (18): e2015151118
Jin S, Fei H, Zhu Z, Luo Y, Liu J, Gao S, Zhang F, Chen YH, Wang Y, Gao C. (2020) "Rationally Designed APOBEC3B Cytosine Base Editors with Improved Specificity", Molecular Cell. 79(5):728-740.e6.
Li C, Zhang R, Meng XB, Chen S, Zong Y, Lu CJ, Qiu, JL, Chen YH, Li JY* & Gao CX*. (2020) "Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors", Nature Biotechnology 2020: 1-8.
Gao D, Zhou T, Da LT, Bruhn T, Guo LL, Chen YH, Xu J, Xu MJ. (2019) "Characterization and Nonenzymatic Transformation of Three Types 2 of Alkaloids from Streptomyces albogriseolus MGR072 and Discovery 3 of Inhibitors of Indoleamine 2,3-Dioxygenase", Organic Letter 21(21):8577-8581.
Zhang Y, Huang X, Wang J, Wang X, Liu X, Chen YH, Xu W, Wang Y. (2019) "Nitration-induced ubiquitination and degradation control quality of ERK1", Biochemistry Journal 476(13):1911-1926.
Wang XH, Su M, Gao F, Xie WJ, Zeng Y, Li DL, Liu XL, Zhao H, Qin L, Li F, Liu Q, Clarke OB, Lam SM., Shui GH, Hendrickson WA.* & Chen YH* (2019) "Structural basis for activity of TRIC counter-ion channels in calcium release", PNAS 116 (10):201817271.
Yang J, Sun S, Zhang S, Gonzalez M, Dong Q, Chi Z, Chen YH & Li F*.(2018) "Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation", PLoS Genetics 14(8): e1007572.
He HJ, Li Y, Dong QH, Chang AY, Gao F, Chi ZhX, Su M, Zhang FB, Bana H, Martienssend R, Chen YH* &LiF*.(2017) "Coordinated regulation of heterochromatin inheritance by Dpb3–Dpb4 complex", PNAS 114,12524-12529. (*co-corresponding author)
Su M, Gao F, Yuan Q, Mao Y, Li Dl, Guo YZ, Cheng Y, Wang XH, Bruni R, Kloss B, Zhao H, Zeng Y, Zhang FB, Marks AR., Hendrickson WA. & Chen YH. (2017) "Structural basis for conductance through TRIC cation channels", Nature Communications 8:15103.
Dong QH, Yin FX, Gao F, Shen Y, Zhang FB, He HJ, Gonzalez M, Yang JP, Zhang S, Li Y, Su M, Chen YH* & Li F*. (2016) " Ccp1 homodimer mediates chromatin integrity by antagonizing CENP-A loading", Molecular Cell 64, 79–91.
Chen YH, Hu L, Punta M, Bruni R, Hillerich B, Kloss B, Love J. Siegelbaum SA & Hendrickson WA. (2010) "Homology structure of the SLAC1 anion channel for stomata closure in leaves", Nature 467(7319): 1074-80.
Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson WA, Melia TJ, Rothman JE. (2009) "Alternative zippering as an on-off switch for SNARE-mediated fusion", Science 323 (5913): 512-6.
Chen YH, He LL, Buchanan DR, Zhang Y, Fitzmaurice A, Yang J. (2009) "Functional dissection of the intramolecular Src homology 3-guanylate kinase domain coupling in voltage-gated Ca2+ channel beta-subunits", FEBS Letter 583(12): 1969-75.
Zhang Y, Chen YH, Bangaru SD, He L, Abele K, Tanabe S, Kozasa T, Yang J. (2008) "Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels", Journal Neuroscience 28(52): 14176- 88
He LL, Zhang Y, Chen YH, Yamada Y, Yang J.(2007) "Functional modularity of the beta-subunit of voltage-gated Ca2+ channels", Biophyscal Jouranl 93(3): 834-45
Chen YH, Li MH, Zhang Y, He LL, Yamada Y, Fitzmaurice A, Shen Y, Zhang H, Tong L, Yang J. (2004) "Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels", Nature 429(6992):675-80.
团队合照:
