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    姓　　名： 税光厚
    职　　称： 研究员
    职　　务： 脂组学平台主任
    电话/传真： 86-10-64807781
    电子邮件： ghshui@genetics.ac.cn
    实验室主页：
    研究方向： 前沿组学技术研发及重大疾病代谢调控机制研究

    简历介绍：

    税光厚，博士, 研究员，博士生导师

    　　2004年获新加坡国立大学 (National University of Singapore)博士学位，同年进入新加坡国立大学生物化学系从事博士后研究。2008-2012年任新加坡国立大学生命科学院高级研究员；2013年加入中国科学院遗传与发育生物学研究所，研究员。目前担任Journal of Lipid Research, Life Metabolism, European J Lipid Sci Technol 等期刊编委。

    研究领域：

    　　（1）开发多层次（“常规-痕量-单细胞水平”）的前沿组学分析方法及代谢流技术，（2）开发脂质组学数据库和发展“脂质代谢通路分析”软件，开发深度代谢通路分析软件和多维度数据整合分析系统，（3）以果蝇、小鼠等作为模式生物系统研究膜脂代谢稳态的生物学意义，（4）开展功能脂质、代谢异常和相关重大疾病的内在联系等相关机制研究。

     

    　　2024年研究生招生计划：普博1名，工程硕士1名（愿意转博考生优先）

    社会任职：

    获奖及荣誉：

    承担科研项目情况：

    代表论著：

    近年代表作品（*通讯作者）
    1. Xia JG, Li B, Zhang H, Li QX, Lam SM, Yin CL*, Tian H*, Shui G*. Precise Metabolomics Defines Systemic Metabolic Dysregulation Distinct to Acute Myocardial Infarction Associated With Diabetes. Arterioscler Thromb Vasc Biol.  43(2023):581-596.
    2. Wang Z, Cao M, Lam SM, Shui G*. Embracing lipidomics at single-cell resolution: Promises and pitfalls. Trends in Analytical Chemistry,2023, 160:116973.
    3. Mu J, Lam SM*, Shui G*. Emerging roles and therapeutic potentials of sphingolipids in pathophysiology --emphasis on fatty acyl heterogeneity. J Genet. Genomics. 2023.
    4. Ma T, Mao W, Zhang S, Wang Y, Wang T, Liu J, Shi L, Yu X, Xue R*, Shui G*, Xu Z*. Ablation of Mea6/cTAGE5 in oligodendrocytes significantly impairs white matter structure and lipid content, Life Metabolism, 2023,2(2).
    5. Yan C, Ma X, Lam SM, Zhang Y, Cao Y, Dong Y, Su L, Shui G*, Feng Y*. Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation. J Mol Cell Biol. 2023. doi: 10.1093/jmcb/mjad014.
    6. Chen X, Li J, Gao Z, Yang Y, Kuang W, Dong Y, Chua GH, Huang X, Jiang B, Tian H, Wang Y, Huang X, Li Y, Lam SM*, Shui G*. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. National Science Review, 2022, 9(12) nwac148.
    7. Miao H, Li BW, Wang ZH, Mu JM, Tian YL, Jiang BH, Zhang SH, Gong X, Shui G*, Lam SM*. Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation. Research. 2022:2022;0006.
    8. Lam SM, Li J, Sun H, Mao W, Lu Z, Zhao Q, Han C, Gong X, Jiang B, Chua GH, Zhao Z, Meng F*, Shui G*. Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic Pathways Underlying Troglomorphic Adaptations in Cave-Dwelling Fish. Mol Biol Evol. 2022, 39(4):msac050. 
    9. Cao M, Zhang S, Lam SM, Shui G*. Hepatic loss of CerS2 induces cell division defects via a mad2-mediated pathway. Clin Transl Med.  2022, 12(1): e712
    10. Lam SM, Huang X*, Shui G*. Trends Endocrinol Metab. 2022, 33(8):554-568.
    11. Tian H, Ni Z, Lam SM, Jiang W, Li F, Du J*, Wang Y*, Shui G*. Precise Metabolomics Reveals a Diversity of Aging-Associated Metabolic Features. Small Methods 2022, 6(7):e2200130.
    12. Luo XM, Lam SM, Dong Y, Ma XJ, Yan C, Zhang YJ, Cao Y, Su L, Lu G, Yang JK, Shui G*, Feng YM*. The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression. Commun Biol. 2022, 5(1):1088. 
    13. Lam SM, Zhang Chao, Wang Z, Ni Z , Zhang S, Yang S, Huang X, Mo L, Li J, Lee B, Mei M, Huang L, Shi M, Xu Z, Meng FP, Cao WJ, Zhou MJ, Shi L, Chua GH, Li B, Cao J, Wang J, Bao S, Wang Y, Song JW*, Zhang F*, Wang FS*, Shui G*. A multi-omics investigation on the composition and function of extracellular vesicles along the temporal trajectory of COVID-19. Nature Metabolism: 2021, (7):909-922.
    14. Wang X, Lam SM, Cao M, Wang T, Wang Z, Yu M, Li B, Zhang H, Ping F, Song G, Feng K, Zhang Q, Xu J, Zhou L, Deng M, Zhai X, Xiao X*, Shui G*. Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY. Redox Biol. 2021, 40:101855. 
    15. Bai X, Lam SM, Nie PC, Xu, M, Liu SJ, Shui GH*, Hu, GQ*. Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant. Environmental Science: Nano 2022, 9(11):4150-4161
    16. Lam SM, Wang Z, Li B, Shui G*. High-coverage lipidomics for functional lipid and pathway analyses. Anal Chim Acta. 2021, 1147:199-210.
    17. Li P, Wang Z, Lam SM*, Shui G*. Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans. Antioxidants (Basel). 2021, 10:262.
    18. Xu D, Lam SM, Zuo J, Yuan S, Lv J, Shi J, Gao L, Chen B, Sui Y, Shui G*, Geng S*, Wang Q*. Lipidomics reveals the difference of membrane lipid catabolism between chilling injury sensitive and non-sensitive green bell pepper in response to chilling. Postharvest Biology and Technology 2021, 182:111714.
    19. Song JW#, Lam SM#, Fan X#, Cao WJ, Wang SY, Tian H, CHUA GH, Zhang C, Meng FP, Xu Z, Fu JL, Huang L, Xia P, Yang T, Zhang SH, Li BW, Jiang TJ, Wang RX, Wang ZH, Shi M, Zhang JY*, Wang FS*, Shui G*, Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis. Cell Metabolism. 2020, 32: 188-202.
    20. Lam SM#, Zhou TX#, Li J#, Zhang SH, Chua GH, Li BW, Shui G*. A robust, integrated platform for comprehensive analyses of acyl-coenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development. Science Bulletin, 65(2020), 1840-1848.
    21. Wang R，Li B，Lam SM*，Shui G*. Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression. J Genet. Genomics. 2020 Feb 20;47(2):69-83.
    22. Shi Y, Lam SM, Liu H, Luo G, Zhang J, Yao S, Li J, Zheng L, Xu N, Zhang X*, Shui G*. Comprehensive lipidomics in apoM-/- mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation. J Genet. Genomics. 47(2020):523-534.
    23. Zhang C, Hao C, Shui G*, Li W*. BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor. Elife, 2020, 9:e58069.
    24. Li R, Sun Q, Lam SM, Chen R, Zhu J, Gu W, Zhang L, Tian H, Zhang K, Chen LC, Sun Q, Shui G*, Liu C*. Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice. Part Fibre Toxicol. 2020, 17(1):14.
    25. Tian H, Zhou Z, Shui G*, Lam SM*. Extensive Profiling of Polyphenols from two Trollius Species using a combination of untargeted and targeted approaches. Metabolites. 2020 Mar 23;10(3).
    26. Wang W, Li S, Li Z, Zhang J, Fan K, Tan G, Ai G, Lam SM, Shui G, Yang Z, Lu H, Jin P, Li Y, Chen X, Xia X, Liu X, Dannelly HK, Yang C, Yang Y, Zhang S, Alterovitz G, Xiang W, Zhang L. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. Nat Biotechnol. 2020, 38(1):76-83.
    27. Lu J, Lam SM, Wan Q, Shi L, Huo Y, Chen L, Tang X, Li B, Wu X, Peng K, Li M, Wang S, Xu Y, Xu M, Bi Y, Ning G, Shui G*, Wang W*. High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults. Diabetes Care. 42(2019):2117-2126.
    28. Ma J, Wang R, Lam SM, Zhang C, Shui G*, Li W*. Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids. Biosci Rep. 2019, 39(2): BSR20182339.
    30. Wang W, Xin J, Yang X, Lam SM, Shui G*, Wang Y*, Huang X*. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Biochim Biophys Acta Mol Cell Biol Lipids. 2018, 1864(2):168-180. 
    31. Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science. 2018, 362(6418).
    32. Lam SM, Wang Z, Li J, Huang X, Shui G*: Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival. Redox Biol 2017(12), 12:967-977.
    33. Lam SM, Wang Y, Li B, Du J, Shui G*: Metabolomics through the lens of precision cardiovascular medicine. J Genet Genomics 2017, 44(3):127-138.
    34. Tian H, Lam SM, Shui G*. Metabolomics, a Powerful Tool for Agricultural Research. Int J Mol Sci 11(2016):1871.
    35. Lam SM, Chua GH, Li XJ, Su B, Shui G*. Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging. Oncotarget 7 (2016): 55970-89.
    36. Lam SM, Tian H, Shui G*: Lipidomics, en route to accurate quantitation. BBA-Mol Cell Biol Lipids 2017, 1862(8):752-761.
    37. Xiang Y, Lam SM, Shui G*. What can lipidomics tell us about the pathogenesis of Alzheimer disease? Biol Chem. 396(2015):1281-91
    39.  Lam SM, Tong L, Reux B, Duan X, Petznick A, Yong SS, Khee CB, Lear MJ, Wenk MR, Shui G*. Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eyesyndrome. J Lipid Res 55(2014):299-306.
    40. Lam SM, Tong L, Duan X, Petznick A, Wenk MR, Shui G*. Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles. J Lipid Res 55(2014):289-298.
    41. Shui G*，Huang X*. Lipid is moving to the forefront of bio-medical research. J Genet Genomics. 41(2014): 229-30.
    42. Cheong WF, Wenk MR, Shui G*. Comprehensive compositional study of lipid molecular species in crude palm oil using multiple lipidomic approaches. J Genet Genomics. 41(2014):293-304
    43. Lam S.M., Wang Y., Duan XR, Wenk MR, Kalaria,RN, Chen CP, Lai MKP，Shui G*. The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia. Neurobiology of Aging, 35(2014):2369-81.
    44. Liu Y, Wang W, Shui G*, Huang X*. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. Plos Genetics. 10(2014), e1004172.
    45. Guyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang XD, Wenk MR, Goh ELK, Silver DL. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509(2014):503-6.
     
    其他文章（*通讯作者，#共同第一）
    46. Chen Q,Li H,Tian H,Lam S M,Liao Y,Zhang Z,Dong M,Chen S,Yao Y,Meng J,Zhang Y,Zheng L,Meng Z X,Han W,Shui G,Zhu D,Fu S, Global determination of reaction rates and lipid turnover kinetics in Mus musculus. Cell Metabolism，2023, 35 (4), 711-721.e4.
    47. Wu H M,Xie D J,Jia P F,Tang Z S,Shi D Q,Shui GH,Wang G D,Yang W C, Homeostasis of flavonoids and triterpenoids most likely modulates starch metabolism for pollen tube penetration in rice. Plant Biotechnol J，2023.
    48. Chen L,Zhang Q,Meng Y,Zhao T,Mu C,Fu C,Deng C,Feng J,Du S,Liu W,Geng G,Ma K,Cheng H,Liu Q,Luo Q,Zhang J,Du Z,Cao L,Wang H,Liu Y,Lin J,Chen G,Liu L,Lam S M,Shui G,Zhu Y,Chen Q, Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function. EMBO Rep 2023, 24 (4), e54731.
    49. Zhu J,Meng W,Lam S M,Shui G,Huang X, Phosphatidylcholine deficiency increases ferroptosis susceptibility in the Caenorhabditis elegans germline. J Genet Genomics, 2023, 50 (5), 318-329.
    50. Gu WJ, Wang RQ, Cai ZW, Lin XJ, Zhang L, Chen RC, Li R, Zhang WH, Ji XM, Shui GH, Sun QH, Liu CQ. Hawthorn total flavonoids ameliorate ambient fine particulate matter-induced insulin resistance and metabolic abnormalities of lipids in mice. Ecotoxicology and Environmental Safety, 2023, 249(1),114456.
    51. Yang M Y,Yang X,Yan Z,Chao Q,Shen J,Shui GH,Guo P M,Wang B C, OsTST1, a key tonoplast sugar transporter from source to sink, plays essential roles in affecting yields and height of rice (Oryza sativa L.). Planta, 2023, 258 (1), 4.
    52. Bao X,Ma X,Huang R,Chen J,Xin H,Zhou M,Li L,Tong S,Zhang Q,Shui G,Deng F,Yu L,Li M D,Zhang Z, Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice. J Mol Cell Biol 2022, 14 (8).
    53. Choo S W,Chong J L,Gaubert P,Hughes A C,O'Brien S,Chaber A L,Antunes A,Platto S,Sun N C,Yu L,Koepfli K P,Suwal T L,Thakur M,Ntie S,Panjang E,Kumaran J V,Mahmood T,Heighton S P,Dorji D,Gonedelé B S,Nelson B R,Djagoun C,Loh I H,Kaspal P,Pauklin S,Michelena T,Zhu H,Lipovich L,Tian X,Deng S,Mason C E,Hu J,White R,Jakubovics N S,Wee W Y,Tan T K,Wong K T,Paterson S,Chen M,Zhang Y,Othman R Y,Brown L C,Shen B,Shui G,Ang M Y,Zhao Y,Li Y,Zhang B,Chong C T,Meng Y,Wong A,Su J,Omar H,Shen H,Tan C H,Xu H,Paterson I C,Wang M,Chan C K,Zhang S,Dutta A,Tee T S,Juvigny-Khenafou N P D,Mutha N V R,Aziz M A, A collective statement in support of saving pangolins. Sci Total Environ， 2022, 824, 153666.
    54. Deng Z,Yang Y,Luo J,Zhang B,Liu J,Shui G,Jiao R,Wei C, An Integrated Transcriptomics and Lipidomics Analysis Reveals That Ergosterol Is Required for Host Defense Against Bacterial Infection in Drosophila. Front Immunol，2022, 13, 933137.
    55. Guo Z,Jiang C H,Tong C,Yang Y,Wang Z,Lam S M,Wang D,Li R,Shui G,Shi Y S,Liu J J, Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation. Cell Rep， 2022, 38 (9), 110452.
    56. Qiu Z,Wang X,Yang Z,Liao S,Dong W,Sun T,Wu H,Zhang Q,Pan Z,Lam S M,Shui G,Jin J, GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway. Cell Death Dis，2022, 13 (5), 508.
    57. Wang Y,Zhai J,Qi Z,Liu W,Cui J,Zhang X,Bai S,Li L,Shui G,Cui S, The specific glycerolipid composition is responsible for maintaining the membrane stability of Physcomitrella patens under dehydration stress. J Plant Physiol，2022, 268, 153590.
    58. Wu S,Lam S M,Li H,Jiang B,Sun Z,Zhu T,Wei X,Zou X,Shui G,Sui R, Targeted lipidomics reveals plasmalogen phosphatidylethanolamines and storage triacylglycerols as the major systemic lipid aberrations in Bietti crystalline corneoretinal dystrophy. J Genet Genomics， 2022, 49 (4), 380-383.
    59. Xin H,Zhang J,Huang R,Li L,Lam SM,Shui G,Deng F,Zhang Z,Li M D, Circadian signatures of adipose tissue in diet-induced obesity. Front Physiol，2022, 13, 953237.
    60. Xu J,Chen S,Wang W,Man Lam S,Xu Y,Zhang S,Pan H,Liang J,Huang X,Wang Y,Li T,Jiang Y,Wang Y,Ding M,Shui G,Yang H,Huang X, Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis. Sci Bull，2022, 67 (3), 299-314.
    61. Yu Y,Liu B,Liu X,Zhang X,Zhang W,Tian H,Shui G,Wang W,Song M,Wang J, Mesenteric lymph system constitutes the second route in gut-liver axis and transports metabolism-modulating gut microbial metabolites. J Genet Genomics，2022, 49 (7), 612-623.
    62. Yue F,Xing L,Wu S,Wei L,Zhou Z,Shi Y,Lam S M,Shui G,Xiang X,Russell R,Zhang D, Constant light exposure alters gut microbiota and short-/medium-chain fatty acids and aggravates PCOS-like traits in HFD-fed rats. Obesity (Silver Spring) 2022, 30 (3), 694-706.
    63. Zhang Y,Ji S,Zhang X,Lu M,Hu Y,Han Y,Shui G,Lam S M,Zou X, Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells. Int J Biol Sci 2022, 18 (13), 4963-4983.
    64. Liu Z C,Wu W H,Huang S,Li Z W,Li X,Shui GH,Lam S M,Li B W,Li Z X,Zhang Y,Zhou T,You W C,Pan K F,Li W Q, Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer: a prospective targeted lipidomics study. Theranostics 2022, 12 (10), 4671-4683.
    65. Zhu J, Lam SM, Yang L, Liang J, Ding M, Shui G, Huang X. Reduced phosphatidylcholine synthesis suppresses the embryonic lethality of seipin deficiency, Life Metabolism 2022, 1 (2), 175–189.
    66. Ma P,Wang Z,Wang Y,Hou B,Sun J,Tian H,Li B,Shui G,Yang X,Yang X,Qiang G,Liew C W,Du G, Integration of Metabolomics and Transcriptomics Reveals Ketone Body and Lipid Metabolism Disturbance Related to ER Stress in the Liver. J Proteome Res 2021, 20 (8), 3875-3888.
    67. Mak H Y,Ouyang Q,Tumanov S,Xu J,Rong P,Dong F,Lam S M,Wang X,Lukmantara I,Du X,Gao M,Brown A J,Gong X,Shui G,Stocker R,Huang X,Chen S,Yang H, AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway. Nat Commun 2021, 12 (1), 6877.
    68. Méndez-Sánchez N,Bugianesi E,Gish R G,Lammert F,Tilg H,Nguyen M H,Sarin S K,Fabrellas N,Zelber-Sagi S,Fan J G,Shiha G,Targher G,Zheng M H,Chan W K,Vinker S,Kawaguchi T,Castera L,Yilmaz Y,Korenjak M,Spearman C W,Ungan M,Palmer M,El-Shabrawi M,Gruss H J,Dufour J F,Dhawan A,Wedemeyer H,George J,Valenti L,Fouad Y,Romero-Gomez M,Eslam M, Global multi-stakeholder endorsement of the MAFLD definition. Lancet Gastroenterol Hepatol 2022, 7 (5), 388-390.
    69. Zhao H,Zhao J,Wu D,Sun Z,Hua Y,Zheng M,Liu Y,Yang Q,Huang X,Li Y,Piao Y,Wang Y,Lam S M,Xu H,Shui G,Wang Y,Yao H,Lai L,Du Z,Mi J,Liu E,Ji X,Zhang Y Q, Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications. Sci China Life Sci 2022, 65 (7), 1342-1356.
    70. Pan Y,Li Y,Liu P,Zhang Y,Li B,Liu Z,Shui G,Ma L, Metabolomics-Based Frailty Biomarkers in Older Chinese Adults. Front Med (Lausanne) 2021, 8, 830723.
    71. Wang Z,Ma P,Wang Y,Hou B,Zhou C,Tian H,Li B,Shui G,Yang X,Qiang G,Yin C,Du G, Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung. Sci Rep 2021, 11 (1), 14680.
    72. Wen H, You H, Li Y, Ma K, Jiao M, Wu S, You S, Huang J, Su J, Gu Y,Wang Z, Zheng P, Shui G,Wang Y,Jin M,Du J, Higher Serum Lysophosphatidic Acids Predict Left Ventricular Reverse Remodeling in Pediatric Dilated Cardiomyopathy. Front Pediatr 2021, 9, 710720.
    73. Zhang Z,Shui G,Li M D, Time to eat reveals the hierarchy of peripheral clocks. Trends Cell Biol 2021, 31 (11), 869-872.
    74. Zhou H,Wu Y,Jiang B,Li B,Li M,Tian H,Shui G,Lam SM, Kwok T, Metabolic Basis of Cognitive Improvement Associated With Active B Vitamin Supplementation in Cognitively Impaired Elderly Subjects - A Metabolomics Study. Front Med (Lausanne) 2022, 9, 864152.
    75. Hu M,Zhao H,Yang B,Yang S,Liu H,Tian H,Shui G,Chen Z,E L,Lai J,Song W, ZmCTLP1 is required for the maintenance of lipid homeostasis and the basal endosperm transfer layer in maize kernels. New Phytol 2021, 232 (6), 2384-2399.
    76. Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ. Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer. JAMA Netw Open. 4(2021): e2114186. 
    77. Wu L, Liu C, Chang DY, Zhan R, Zhao M, Lam SM, Shui G, Zhao MH, Zheng L, Chen M.
    The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through AMPK/PPARα/CPT1b pathway. Diabetes. 2021, 70:2192-2203.
    78.  Li J, Zeng Y, Pan Y, Zhou L, Zhang Z, Guo H, Lou Q, Shui G, Huang H, Tian H, Guo Y, Yuan P, Yang H, Pan G, Wang R, Zhang H, Yang S, Guo Y, Ge S, Li J, Li Z. Stepwise selection of natural variations at CTB2 and CTB4a improves cold adaptation during domestication of japonica rice. New Phytol. 231(2021):1056-1072. 
    79. Xin H, Deng F, Zhou M, Huang R, Ma X, Tian H, Tan Y, Chen X, Deng D, Shui G, Zhang Z, Li MD. A multi-tissue multi-omics analysis reveals distinct kineztics in entrainment of diurnal transcriptomes by inverted feeding. iScience. 24(2021):102335. 
    80. Zhou X, Gao Y, Wang W, Yang X, Yang X, Liu F, Tang Y, Lam SM, Shui G, Yu L, Tian C, Guddat LW, Wang Q, Rao Z, Gong H. PNAS;118(2021): e2022308118. 
    82. Shen L, Hu P, Zhang Y, Ji Z, Shan X, Ni L, Ning N, Wang J, Tian H, Shui G, Yuan Y, Li G, Zheng H, Yang XP, Huang D, Feng X, Li MJ, Liu Z, Wang T, Yu Q. Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation. Cell Metabolism, 2021 33(2021):971-987.
    83. Pang Q, Liu C, Qiao Y, Zhao J, Lam SM, Mei M, Shui G, Bao S, Li Q. GM130 regulates pulmonary surfactant protein secretion in alveolar type II cells. Sci China Life Sci. 2021. doi: 10.1007/s11427-020-1875-x. 
    84. Ye J, Ye X, Jiang W, Lu C, Geng X, Zhao C, Ma Y, Yang P, Man Lam S, Shui G, Yang T, Zhong Li J, Gong Y, Fu Z, Zhou H. Targeted lipidomics reveals associations between serum sphingolipids and insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. Diabetes Res Clin Pract. 173(2021):108699.
    85. Xing G, Li J, Li W, Lam SM, Yuan H, Shui G, Yang J. AP2/ERF and R2R3-MYB family transcription factors: potential associations between temperature stress and lipid metabolism in Auxenochlorella protothecoides. Biotechnol Biofuels. 2021, 14:22. 
    86.Xing C, Li J,Lam SM, Yuan H,Shui G,Yang J.The role of glutathione-mediated triacylglycerol synthesis in the response to ultra-high cadmium stress in Auxenochlorella protothecoides. Journal of Environmental Sciences. 2021, 108: 58-69
    87. Wojnacki J, Nola S, Bun P, Cholley B, Filippini F, Pressé MT, Lipecka J, Man Lam S, N'guyen J, Simon A, Ouslimani A, Shui G, Fader CM, Colombo MI, Guerrera IC, Galli T. Cell Rep. 2020, 33:108536. 
    88. Gong H, Gao Y, Zhou X, Xiao Y, Wang W, Tang Y, Zhou S, Zhang Y, Ji W, Yu L, Tian C, Lam SM, Shui G, Guddat LW, Wong LL, Wang Q, Rao Z. Nat Commun. 2020, 11(1):4245.
    89. He M, Su J, Xu Y, Chen J, Chern M, Lei M, Qi T, Wang Z, Ryder LS, Tang B, Osés-Ruiz M, Zhu K, Cao Y, Yan X, Eisermann I, Luo Y, Li W, Wang J, Yin J, Lam SM, Peng G, Sun X, Zhu X, Ma B, Wang J, Liu J, Qing H, Song L, Wang L, Hou Q, Qin P, Li Y, Fan J, Li D, Wang Y, Wang X, Jiang L, Shui G, Xia Y, Gong G, Huang F, Wang W, Wu X, Li P, Zhu L, Li S, Talbot NJ, Chen X. Discovery of broad-spectrum fungicides that block septin-dependent infection processes of pathogenic fungi. Nat Microbiology, 2020, 5:1565-1575..
    90. Yang L, Liang J, Lam SM, Yavuz A, Shui G, Ding M, Huang X. Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. EMBO Rep. 2020, 21:e50214. 
    91. Meng W, Xu L, Du ZY, Wang F, Zhang R, Song X, Lam SM, Shui G, Li Y, Chye ML. Rice (N Y). 2020, 13:75. 
    92. Liu RQ, Qiao SH, Shen WS, Liu Y, Lu Y, Huang LY, Guo Z, Gong JF, Shui G, Li Y, Zhu WM*. Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocytes Contributes to Chronic Inflammation of Crohn's Disease. J Crohns Colitis. 2020, 14(11):1581-1599..
    93. Wei L, Yue F, Xing L, Wu S, Shi Y, Li J, Xiang X, Lam SM, Shui G, Russell R, Zhang D. Front Microbiol. 2020, 11:1975. Constant Light Exposure Alters Gut Microbiota and Promotes the Progression of Steatohepatitis in High Fat Diet Rats. Front Microbiol. 2020,11:1975
    94. Li R, Wang YX, Hou BY, Lam SM, Zhang WH, Chen RC, Shui G, Sun QH, Qiang GF, Liu CQ*. Lipidomics Insight Into Chronic Exposure to Ambient Air Pollution in Mice. Environ Pollut. 2020, 262:114668.
    95. Quan LH, Zhang C, Dong MJiang J, Xu H, Yan C, Liu X, Zhou H, Zhang H, Chen L, Zhong FL, Luo ZB, Lam SM, Shui G, Li D, Jin W. Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 2020，69(7):1239-1247. 
    96. Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, Li L, Jia J, Pilo M8, Wang J, Cigliano A, Ma Z, Kuang W, Tang Z, Zhang Z, Shui G, Ribback S, Dombrowski F, Evert M, Pascale RM, Cossu C, Pes GM, Osborne TF, Calvisi DF Chen X, Chen L. Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut. 2020, 69(1):177-186.
    97. Hou B, He P, Ma P, Yang X, Xu C, Lam SM, Shui G, Yang X, Zhang L, Qiang G, Du G. Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy. Front Endocrinol (Lausanne). 2020, 11:359.
    98. Shi JH, Lu JY, Chen HY, Wei CC, Xu X, Li H, Bai Q, Xia FZ, Lam SM, Zhang H, Shi YN, Cao D, Chen L, Shui G, Yang X, Lu Y, Chen YX, Zhang WJ. Liver ChREBP Protects Against Fructose-Induced Glycogenic Hepatotoxicity by Regulating L-Type Pyruvate Kinase. Diabetes. 2020; 69(4):591-602.
    99. Zhao H, Ma B, Duan KX, Li XK, Lu X, Yin CC, Tao JJ, Wei W, Zhang WK, Xin P, Lam SM, Chu J, Shui G, Chen SY, Zhang JS. The GDSL Lipase MHZ11 Modulates Ethylene Signaling in Rice Roots. Plant Cell. 2020, 32(5):1626-1643. .
    100.  Li X, Shi Z, Zhu Y, Shen T, Wang H, Shui G, Loor JJ, Fang Z, Chen M, Wang X, Peng Z, Song Y, Wang Z1, Du X, Liu G. Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. Br J Pharmacol. 2020, 177(15):3591-3607.
    101.  Hou B, Zhao Y, He P, Xu C, Ma P, Lam SM, Li B, Gil V, Shui G, Qiang G, Liew CW, Du G. Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue. Life Sci. 2020, 245:117352.
    102.  Wu L, Zhang X, Zheng L, Zhao H, Yan G, Zhang Q, Zhou Y, Lei J, Zhang J, Wang J, Xin R, Jiang L, Peng J, Chen Q, Lam SM, Shui G, Miao H, Li Y. RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis. Cancer Immunol Res. 2020, 8(5):710-721.
    103.  Yue F, Xia K, Wei L, Xing L, Wu S, Shi Y, Lam SM, Shui G, Xiang X, Russell R, Zhang D. Effects of constant light exposure on sphingolipidomics and progression of NASH in high-fat-fed rats. J Gastroenterol Hepatol. 2020, 35(11):1978-1989..
    104.  Chen Y, Lin C, Guo Z, Zhao S, Zhu Y, Huang F, Shui G, Lam SM, Pu J, Yan Y, Liu Z, Zhang B. Altered Expression Profile of Phosphatidylinositols in Erythrocytes of Alzheimer's Disease and Amnestic Mild Cognitive Impairment Patients. J Alzheimers Dis. 2020;73(2):811-818.
    105.  Huang D, Sun Y, Ma Z, Ke M, Cui Y, Chen Z, Chen C, Ji C, Tran TM, Yang L, Lam SM, Han Y, Shui G, Friml J, Miao Y, Jiang L, Chen X. Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization. Proc Natl Acad Sci. 2019, 116(42): 21274-21284.
    106.  Sun X, Li X, Jia H, Wang H, Shui G, Qin Y, Shu X, Wang Y, Dong J, Liu G, Li X. Nrf2 mediates oxidative stress-induced lipid accumulation in adipocytes by increasing adipogenesis and decreasing lipolysis. Antioxid Redox Signal. 2020, 32(3):173-192.
    107.  Yang X, Liang J, Ding L, Li X, Lam SM, Shui G, Ding M, Huang X. Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLoS Genet. 2019,15(12):e1008548.
    108.  He P, Hou B, Li Y, Xu C, Ma P, Lam SM, Gil V, Yang X, Yang X, Zhang L, Shui G, Song J, Qiang G, Liew CW, Du G. Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation. Biomolecules. 2019, 9,444
    109.  Chen L, Ma MY, Sun M, Jiang LY, Zhao XT, Fang XX, Lam SM, Shui GH, Luo J, Shi XJ, Song BL. Endogenous sterol intermediates of the mevalonate pathway regulate HMG-CoA reductase degradation and SREBP-2 processing. J Lipid Res. 60(2019):1765-1775.
    110.  Pan J, Tao C, Cao C, Zheng Q, Lam SM, Shui G, Liu X, Li K, Zhao J, Wang Y. Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs. Biochim Biophys Acta Mol Cell Biol Lipids. 1864(2019):1375-1383.
    111.  Cao Z, Hao Y, Fung CW, Lee YY, Wang P, Li X, Xie K, Lam WJ, Qiu Y, Tang BZ, Shui G, Liu P, Qu J, Kang BH, Mak HY. Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain. Nat Commun. 10(2019):2902.
    112.  Pan S, Lin Y, Liu Q, Duan J, Lin Z, Wang Y, Wang X, Lam SM, Zou Z, Shui G, Zhang Y, Zhang Z, Zhan X. Convergent genomic signatures of flight loss in birds suggest a switch of main fuel. Nat Commun. 2019, 10(1):2756.
    113.  Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.
    114.  Wang XH, Su M, Gao F, Xie W, Zeng Y, Li DL, Liu XL, Zhao H, Qin L, Li F, Liu Q, Clarke OB, Lam SM, Shui GH, Hendrickson WA, Chen YH. Structural basis for activity of TRIC counter-ion channels in calcium release. Proc Natl Acad Sci. 2019, 116(10): 4238-43.
    115.  Liu Y, Ji Y, Li X, Shui G, Huang X. Lipid storage regulator CdsA is essential for Drosophila metamorphosis. J Genet Genomics. 2019, 46(4):231-234.
    116.  Wang X, Cao C, Li Y, Hai T, Jia Q, Zhang Y, Zheng Q, Yao J, Qin G, Zhang H, Song R, Wang Y, Shui G, Lam SM, Liu Z, Wei H, Meng A, Zhou Q, Zhao J. A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment. J Mol Cell Biol. 2019, 11(12):1029-1041.
    117.  Si X, Li Y, Shang W, Shui G, Lam SM, Blanchard CL, Strappe P, Zhou Z. Gamma-Aminobutyric Acid Attenuates High-Fat Diet Induced Cerebral Oxidative Impairment via Enhanced Synthesis of Hippocampal Sulfatides. J Agric Food Chem. 2019; 67(4):1081-1091/
    118.  Zhang F, Wang Y, Wang T, Yao L, Lam SM, Huang X, Fan J, Wang Q, Liu L, Jiang Y, Zhang H, Shi L, Yu M, Shui G, Wang Y, Gao F, Zhang X, Xu Z. cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. PNAS. 2018, 115(40):E9449-E9458.
    119.  Deng X, Yuan S, Cao H, Lam SM, Shui G, Hong Y, Wang X. Phosphatidylinositol-hydrolyzing phospholipase C4 modulates rice response to salt and drought. Plant Cell Environ. 2019;42(2):536-548.
    120.  Ding L, Yang X, Tian H, Liang J, Zhang F, Wang G, Wang Y, Ding M, Shui G, Huang X. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J. 2018, 37(17): e97572.
    121.   Li TY, Song L, Sun Y, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018, 15;9(1):1916.
    122.  Liao J, Guan Y, Chen W, Shi C, Yao D, Wang F, Lam SM, Shui G, Cao X. ACBD3 is required for FAPP2 transferring glucosylceramide through maintaining the Golgi integrity. J Mol Cell Biol. 2019;11(2):107-117..
    124.  Gao M, Yin X, Yang W, Lam SM, Tong X, Liu J, Wang X, Li Q, Shui G, He Z, GDSL lipases modulate immunity through lipid homeostasis in rice. PLoS pathogens 2017, 13(11):e1006724.
    125.  Tian H, Li B, Shui G*, Untargeted LC–MS Data Preprocessing in Metabolomics. Journal of Analysis and Testing 2017, 1:187-192.
    126.  Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindstrom-Battle A , Lam SM, Shui G, Deng W, Jiao R*, HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. Dev Cell 2017, 43(1):99-111.
    127.  Fan W, Lam SM, Xin J, Yang X, Liu Z, Liu Y, Wang Y, Shui G, Huang X: Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. Plos Genet 2017, 13(3) :e1006664.
    128.  Zhang J, Zhang Y, Wu W, Wang F, Liu X, Shui G, Nie CL: Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion. Cell Death Dis 2017, 8(10):e3151
    129.  Li Q, Lu X, Song Q, Chen H, Wei W, Tao J, Bian X, Shen M, Ma B, Zhang W, Bi Y, Li W, Lai Y, Lam SM, Shui G, Chen S, Zhang J, Selection for a Zinc-Finger Protein Contributes to Seed Oil Increase during Soybean Domestication. Plant Physiol 2017, 173(4):2208-2224.
    130.  Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu MJ, Pei RJ, Chen XW*: Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. BBA-Mol Cell Biol L 2017, 1862(7):692-705.
    131.  Huang Y, Huang S, Lam SM, Liu Z, Shui G, Zhang YQ. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. J Cell Sci 129(2016):4034-4045.
    132.  Wang Y, Liu L, Zhang H, Fan J, Zhang F, Yu M, Shi L, Yang L, Lam SM, Wang H, Chen X, Wang Y, Gao F, Shui G, Xu Z. Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Res. 26(2016):787-804.
    133.  Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, et al. Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study. J Alzheimers Dis. 50(2016):887-94.
    134.  Begum H, Li B, Shui G, Cazenave-Gassiot A, Soong R, Ong RT, Little P, Teo YY, Wenk MR. Discovering and validating between-subject variations in plasma lipids in healthy subjects. Sci Rep. 6(2016):19139
    135.  Jin J, Li Y, Ren J, Lam SM, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ. Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 54(2016):410-23.
    136.  Heinz LX, Baumann CL, K？berlin MS, Snijder B, Gawish R, Shui G, et al. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep. 11(2015):1919-28.
    137.  Chua EC, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ. Changes in Plasma Lipids during Exposure to Total Sleep Deprivation. Sleep. 38(2015):1683-91.
    138.  Portevin D, Sukumar S, Coscolla M, Shui G, Li B, Guan XL, Bendt AK, Young D, Gagneux S, Wenk MR. Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis. Microbiologyopen.3(2014):823-35.
    139.  Nakamura Y, Teo NZ, Shui G, Chua CH, Cheong WF, Parameswaran S, Koizumi R, Ohta H, Wenk MR, Ito T. Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development. New Phytol. 203(2014):310-22。
    140.  Liu L, Jiang Q, Wang X, Zhang Y, Lin RC, Lam SM, Shui G, Zhou L, Li P, Wang Y, Cui X, Gao M, Zhang L, Lv Y, Xu G, Liu G, Zhao D, Yang H. Adipose-specific knockout of Seipin/Bscl2 results in progressive lipodystrophy. Diabetes, 63(2014):2320-31.
    141.  Zhang S, Shui G, Wang G, Wang C, Sun S, Zouboulis CC, Xiao R, Ye J, Li W, Li P. Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands. Mol Cell Biol. 34(2014):1827-38.
    142.  Ng LF, Gruber J, Cheah I, Kiat Goo C, Fun Cheong W, Shui G, Ping Sit K, Wenk MR, Halliwell B. The mitochondria-targeted antioxidant, MitoQ extends lifespan and improves healthspan of a transgenic C. elegans models of Alzheimer disease. Free Radic Biol Med. 71(2014):390-4.
    143.  Liu YF, Li QT, Lu X, Song QX, Lam SM, Zhang WK, Ma B, Lin Q, Man WQ, Du WG, Shui GH, Chen SY, Zhang JS. Soybean GmMYB73 promotes lipid accumulation in transgenic plants. BMC Plant Biol. 14(2014):73.
    144.  Ang ML, Zainul Rahim SZ, Shui G, et al, Alonso S. An ethA/R-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo which correlate with altered mycolic acids composition. Infection and Immunity 82(2014):1850-9.
    145.  Ee SM, Lo YL, Shui G, Wenk MR, Shin EJ, Kim HC, Ong WY. Distribution of Secretory Phospholipase A2 XIIA in the Brain and its Role in Lipid Metabolism and Cognition. Mol Neurobiol. 50(2014):60-75.
    146.  Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk M, Shen HM. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled Akt-FoxO1 signalling pathway. Autophagy 10(2014):226-42.
    147.  Xue Y, Shui G, Wenk MR. TPS1 drug design for rice blast disease in magnaporthe oryzae. Springerplus 3(2014):18.
    148.  Yaligar J, Gopalan V, Kiat OW, Sugii S, Shui G, Lam BD, Henry CJ, Wenk MR, Tai ES, Velan SS. Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques. PLoS One 9(2014):e91436.
    149.  Chua ECP#, Shui G#, Lee I, Lau P; Tan LC, Yeo SY, Lam BD, Puvanendran K, Bulchand S, Summers SA, Rozen S, Wenk MR, Gooley JJ. Extensive diversity in the circadian lipidome: evidence for different circadian metabotypes. PNAS. 110(2013):14468-73. (#co-first author).
    150.  Shui G*, Lam SM, Stebbins J, Kusunoki J, Duan X, Li B, Wei Cheong F, Soon D, Kelly R, & Wenk M Polar lipid derangements in type 2 diabetes mellitus: potential pathological relevance of fatty acyl heterogeneity in sphingolipid. Metabolomics 4(2013) 786-799.
    151.  Lam SM, Shui G*. Lipidomics as a principal tool for advancing biomedical research. J Genet Genomics. 40(2013):375-90.　
    152.  Lam SM, Tong L, Reux B, Lear MJ, Wenk MR, Shui G*. Rapid and sensitive profiling of tear wax ester species using high performance liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. A. 1308(2013):166-71.
    153.  Liu Z, Lim CY, Su MY, Soh SL, Shui G, Wenk MR, Grove KL, Radda GK, Han W, Xiao X. Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations. J Endocrinol. 219(2013):131-43.
    154.  Lim WL, Lam SM, Shui G, Mondal A, Ong D, Duan X, Creegan R, Martins IJ, Sharman MJ, Taddei K, Verdile G, Wenk MR, Martins RN. Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice. Neurobiol Aging 34(2013):2217-24.
    155.  Jovanovi？ V, Abdul Aziz N, Lim YT, Ng Ai Poh A, Jin Hui Chan S, Ho Xin Pei E, Lew FC, Shui G, Jenner AM, Bowen L, McKinney EF, Lyons PA, Kemeny MD, Smith KG, Wenk MR, Macary PA.Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus. PLoS One 8(2013)：e55639.
    156.  Blanc M, Hsieh wy, Robertson KA, Kai KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P. Signal transducer and activator of transcription (Stat-1) couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity 38(2013):106-18.
    157.  Guan XL, Cestra G，Shui G, Kuhrs A, Schittenhelm R, Hafen E, van der Goot FG, Gonzalez-Gaitan M, Wenk MR. Biochemical membrane lipidomics during Drosophila development -an informational resource. Development Cell 24(2013):98-111.
    158.  Summermatter S, Shui G, Maag D, Santos G, Wenk MR, Handschin C. PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes 62(2013):85-95
    159.  Vigant F, Lee J, Hollman A, Tanner L, Akyol-Ataman Z, Yun T, Shui G, et al. A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. Plos Pathogens 9(2013): e1003297.
    160.  Watterson S, Guerriero ML, Blanc M, Mazein A, Loewe L, Robertson KA, Gibb H, Shui G, Wenk MR, Hillston J and Ghazal P. A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction. Biochimie 95(2013):613-21.
    161.  Chan R, Oliveira TG, Small SA, Duff KE, Wenk MR, Shui G*, Di Paolo G*. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J. Bio. Chem. 287(2012):2678-88.
    162.  Baig S, Lim JY, Fernandis AZ, Wenk MR, Kale A, Su LL, Biswas A, Vasoo S, Shui G*, Choolani M*. Lipidomic analysis of human placental syncytiotrophoblast microvesicles in adverse pregnancy outcomes.Placenta 34(2013):436-42.
    163.  Nakatsu F, Baskin JM, Chung J, Tanner LB, Shui G, Lee SY, Pirruccello M, Ingolia NT, Wenk MR, Camilli PD. A plasma membrane PI4P pool controlled by PI 4-kinase III impacts cholesterol homeostasis. J Cell Biol. 199(2012):1003-1016.
    164.  Thibault G, Shui G, Woong K, McAlister G, Gygi SP, Wenk MR, Ng DTW. The unfolded protein response buffers the lethal effects of lipid disequilibrium. Molecular Cell: 48(2012):16-27.
    165.  Patkar RN, Suresh A, Xue YK, Shui G, Wenk MR, Naqvi NI. Abc3-mediated efflux of an endogenous digoxin-like steroidal glycoside by Magnaporthe oryzae is necessary for host invasion during blast disease. Plos Pathogen 8(2012):e1002888.
    166.  Siddique MM, Bikman BT, Wang L, Ying L, Reinhardt E, Shui G, Wenk MR, Summers SA. Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro. PLoS One: 7(2012):e44042
    167.  Bikman BT, Guan Y, Shui G, Siddique MM, Holland WL, Kim JY, Fabriàs G, Wenk MR, Summers SA. Fenretinide prevents lipid-induced insulin resistance by inhibiting dihydroceramide desaturase and blocking ceramide synthesis. J. Bio. Chem. 287(2012):17426-37.
    168.  Tan SH, Shui G, Zhou J, Wenk MR, Shen HM. Induction of autophagy by palmitic acid via a PKC-mediated signaling pathway independent of Mtor. J. Bio. Chem. 287(2012):14364-76.
    169.  Mathuru AS, Kibat C, Cheong CF, Shui G, Korzh V, Wenk MR, Friedrich RW and Jesuthasan S. Chondroitin fragments are odorants that trigger fear behavior. Current Biology 22(2012):538-44.
    170.  Rodriguez-Navarro JA, Kaushik S, Koga H, Dall’Armi C, Shui G, Wenk MR, Di Paolo G, Cuervo AM. Inhibitory effect of dietary lipids on chaperone-mediated autophagy. PNAS 109(2012):E705-14 .
    171.  Wang WS, Lv Na, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P. Cidea is an essential transcriptional co-activator of C/EBP|？ to control newborn survival and lipid secretion in mammary gland. Nature Medicine 18(2012):235-43.
    172.  Sundram JR, Chan HH, Poore CP, Pareek T, Cheong WF, Shui G, Tan N, Low CM, Wenk MR and Kesavapany S. Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration. J. Neurosci. 32(2012):1020-34.
    173.  Gong J, Sun Z, Wu L, Xu W，Schieber N,Xu D, Shui G, Yang H, Parton RG, Li P. Fsp27 is localized to the contact site of lipid droplets and promotes their growth by fusion. J Cell Biol: 195(2011):953-63.
    174.  Lee HW, Tan CH, Long LY, Farooqui AQ, Shui G, Wenk MR, Ong WY. Lipidomic analyses of the rat brain after transcranial magnetic stimulation. Metabolomics: 8(2012): 19-33.
    175.  Lee HW, Tan CH, Shui G, Wenk MR, Ong WY. Role of prefrontal cortex calcium independent phospholipase A2 activity in the antidepressant like effect of maprotiline. Int J Neuropsychopharmacol. 15(2012):1087-98.
    176.  Ma MT; Yeo JF; Shui G, Wenk MR, Ong WY. Systems wide analyses of lipids in the brainstem during inflammatory orofacial pain -Evidence of increased phospholipase A(2) activity. Eur J Pain 16(2012):38-48.
    177.  Lim L, Jackson-Lewis V, Wong LC, Shui G, Goh XH, Kesavapany S, Jenner AM, Fivaz M, Przedborski S, Wenk MR. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from oxidative stress. Cell Death and Diff.19(2012): 416-27.
    178.  Poh MK, Shui G, Shi PY, Wenk MR, Gu F. The importance of cholesterol during the entry and replication event of dengue virus. Antiviral Res: 93(2012):191-8.
    179.  Shui G*, et al. Mycolic acids as diagnostic markers for tuberculosis case detection and drug efficacy. EMBO Mol Med: 4(2012):27-37.
    180.  Shui G*. Systems level analysis of lipidome. Front. Biol. 6(2011): 183-189
    181.   Shui G*, Cheong WF, Jappar IA, Hoi A, Xue YK, Fernandis AZ, Tan BKH, Wenk MR. Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: Applications to a rabbit model for atherosclerosis. J. Chromatogr. A. 1218 (2011): 4357-4365.
    182.   Shui G*, Stebbins JW, Lam BD, Cheong WF, Lam SM, Gregoire F, Kusonoki J, Wenk MR. Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys? Plos One 6 (2011): e19731
    183.  Fei W, Zhong L, Ta MT, Shui G, Wenk MR, Yang H. The size and phospholipid composition of lipid droplets can influence their proteome. Biochem Biophys Res Commun. 415(2011):455-62.
    184.  Fei W, Li H, Shui G, Bielby C, Du X, Brown AJ, Wenk MR, Li P, Yang H. Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis. J Lipid Res 52(2011):2136-47.
    185.  Lam SM, Tong L, Yong SS, Li BW, Chaurasia SS, Shui G*, Wenk MR*. Meibum lipid composition in Asians with Dry Eye Disease. Plos One 6(2011): e24339
    186.  Fei W#, Shui G#, Zhang P, Fergsuon C, Kapterian TS, Lin RC, Dawes IW, Zhang Y, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC and Yang H. A role for phosphatidic acid in the formation of “supersized” lipid droplets. Plos Genetics7(2011): e1002201. (#co-first author).
    187.  Gruber J, Ng LF, Fong S, Wong YT, Koh SA, Chen CB, Shui G, Cheong WF, Schaffer S, Wenk MR, Halliwell B. Mitochondrial ageing in Caenorhabditis elegans - shutting down rather than vicious cycling. Plos One 6 (2011): e19444
    188.  Tian Y, Bi J, Shui G, Xiang Y, Liu Y, Liu Z, Yang H, Wenk MR, and Huang X. Tissue-autonomous function of Drosophila Seipin in preventing ectopic lipid accumulation. Plos Genetics 7(2011):e1001364.
    189.  Holland WL, Bikman BT, Wang LP, Guan YG, Sargent KM, Knotts TA, Shui G, Wenk MR, Pagliassotti MJ and Summers SA. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin Invest. 121(2011):1858-70.
    190.  Peng ZF, Chen MJ, Manikandan J, Melendez AJ, Shui G, Russo-Marie F, Whiteman M, Beart PM, Moore PK, Cheung NS. Multifaceted involvement of NO in mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signaling cascades. J Cell Mol Med: 16(2012):41-58
    191.  Gamage AM, Shui G, Wenk MR, Chua KL. N-octanoyl homoserine lactone is the major quorum signaling molecule regulating biofilm formation and antibiotic production in B. pseudomallei. Microbiology 157(2011): 1176-1186.
    192.  Blanc M, Watterson S, O’Sullivan MC, Shui G, Gibbs H, Sing S, Khondoker M, Dickinson P, Lacaze P, Wall DM, Rodríguez-Martín S, Riemersma R, Wenk MR, Angulo A, Ghazal P. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. Plos Biology 9(2011): e1000598.
    193.  Cheng D, Jenner AM, Shui G, Cheong WF, Mitchell TW, Nealon JR, Kim WS, McCann H, Wenk MR, Halliday GM, Garner B. Lipid pathway alterations in Parkinson’s disease primary visual cortex. Plos One 6(2011): e17299.
    194.  Oliveira T, Chan R, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff K, Wenk MR, Arancio O and Di Paolo G. Phospholipase D2 ablation ameliorates Alzheimer’s disease-linked synaptic dysfunction and cognitive deficits. J. Neurosci. 30(2010), 16419-16428.
    195.  Low KL, Shui G, Natter K, Yeo WK, Kohlwein S, Dick T, Rao S, Wenk MR.. Lipid droplet-associated proteins in Mycobacterium bovis BCG function in the biosynthesis and hydrolysis of triacylglycerol. J. Bio. Chem. 285(2010):21662-70
    196.   Shui G*, Guan XL, Gopalakrishnan P, Xue Y, Goh JSY, Yang H, Wenk MR Characterization of Substrate Preference for Slc1p and Cst26p in Saccharomyces cerevisiae Using Lipidomic Approaches and Non-radioactive LPAAT Activity Assay. Plos One 5(2010): e11956.
    197.   Shui G*, Guan XL, Low CP, Goh SYJ, Yang H, Wenk MR.. Toward One Step Analysis of Cellular Dynamic Lipidome Using Liquid Chromatography Coupled with Mass Spectrometry: Application to Saccharomyces Cerevisiae and Schizosaccharomyces Pombe Lipidomics. Mol BioSyst 6(2010):1008-17.
    198.  Jenner AM, Lim WLF, Ng MPE, Wenk MR, Shui G, Sharman MJ, Gandy SE, Martins RN. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE e2, e3 and e4 mice. Neurosciences 169(2010):109-15.
    199.  Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM. Dual role of 3-methyladenine on modulation of autophagy via different temporal patterns on Class I and III phosphoinositide 3-kinase. J. Bio. Chem.285(2010):10850-61
    200.  Sharman MJ#, Shui G#, Fernandis AZ, Lim WL, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum J, Gandy S, Wenk MR and Martins RN. Subtle changes in brain and plasma lipids in aged APOE knock-in mice. J Alzheimers Dis. 20(2010):105-11 (#Co-First Author)
    201.  Nakamura Y, Koizumi R, Shui G, Shimojima M, Wenk MR, Ito T, Ohta H. Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism to/and cope critically with phosphate starvation. PNAS 106(2009):20978-83.
    202.  McGehee AM, Dougan SK, Klemm E, Shui G, Park B, Kim YM, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts have normal protein folding but defects in glycosylation and lipid synthesis. Journal of Immunology 183(2009):3690-3699.
    203.  Novem V, Shui G, Wang D, Bendt AK, Sim SH, Liu Y, Thong TW, Sivalingam SP, Ooi EE, Wenk MR, Tan G.Structural characterization and comparison of lipid A from Burkholderia pseudomallei and Burkholderia thailandensis. Clinical and Vaccine Immunology 16(2009):1420-1428
    204.  Low KL, Rao S, Shui G, Bendt AK, Pethe K, Dick T, Wenk MR. Tetrahydrolipstatin, a lipase inhibitor is bactericidal to non-replicative Mycobacterium bovis BCG. Journal of Bacteriol.: 191(2009):5037-43.
    205.  Deng Y, Almsherqi ZA, Shui G, Wenk MR, Kohlwein SD. Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria. FASEB J. 23(2009):2866-71.
    206.  Lee HW, Shui G, Farooqui AQ, Wenk MR, Tan CH, Ong WY. Lipidomic analyses of the mouse brain after antidepressant treatment – evidence for endogenous release of omega-3 fatty acids? Int J Neuropsychopharmacol 12(2009) : 953-964
    207.  Kutik S, Rissler m, Guan X, Guiard B, Shui G, Meisinger G, Rehling P, Wenk MR, Pfanner N, Wiedemann N. The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol. 183(2008):1213-1221.
    208.  Chan R, Uchil OD, Jin J, Shui G, Ott DE, Mothes W, and Wenk MR. Retroviruses Human Immunodeficiency Virus and Murine Leukemia Virus Are Enriched in Phosphoinositides. J Virol. 82(2008): 11228-38.
    209.  Low CP, Shui G, Li PL, Buttner S, Madeo F, Dawes IW, Wenk MR, and Yang H. Distinct lipotoxic cell death pathways in the fission yeast. J Cell Sci. 121(2008):2671-84.
    210.  Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG, Yang H. Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol. 180(2008):473-82.
    211.  Lu LE, Yung LYL, Ong CN, Tan YL, Balasubramaniam S, Hartono D, Shui G, Wenk MR, and Ong WY. Translocation and effects of gold nanoparticles after inhalation exposure in rats. Nanotoxicology 1 (2007), 235-242.
    212.   Shui G, Bendt AK, Pethe K, Dick T and Wenk MR. Sensitive profiling of chemically diverse bioactive lipids. J. Lipid Res. 48(2007):1976-84.
    213.  Wang H, Jenner A, Lee CY, Shui G, Tang SY, Whiteman M, Wenk MR, Halliwell B. The identification of antioxidants in dark soya sauce. Free Radical Res. 41(2007):479-88
    214.  Guan XL, He X, Ong WY, Yeo WK, Shui G. and Wenk MR. Unbiased global profiling of lipids during kainite induced neuronal injury. FASEB J. 20 (2006), 1152-61.
    215.  Huang Q, Shen HM, Shui G, Wenk MR, Wong CN. Emodin inhibits tumor cell adhesion through disruption of the membrane lipid rafts-associated integrin signaling pathway. Cancer Res. 66 (2006), 5807-15.
    216.   Shui G, Leong LP. Residue from star fruitJuice processing waste as a value-added food ingredient and its potential as antioxidant nutraceuticals. Food Chem. 97 (2006), 277-284.
    217.   Shui G, Leong LP. Rapid Screening and Identification of Antioxidants in Biological Samples Using High Performance Liquid Chromatography/Mass Spectrometry and Its Application on Salacca Edulis Reinw. J. Agric. Food Chem. (2005), 53(4), 880-886.
    218.   Shui G, Leong LP and Wong SP. “Rapid Screening and Characterisation of Antioxidants of Cosmos Caudatus Using Liquid Chromatography Coupled with Mass Spectrometry. J. Chromatogr. B. 827(2005), 127-138.
    219.   Shui G, Wong SP, Leong LP. Characterization of Antioxidants and Change of Antioxidant Levels during Storage of Manilkara zapota L. J. Agric. Food Chem. 52(2004), 7834-7841.
    220.   Shui G, Leong LP. An Improved Method for the Analysis of Major Antioxidants of Hibiscus Esculentus Linn. J. Chromatogr. A. 1048 (2004) 17-24.
    221.  Shui G, Leong LP. Analysis of Polyphenolic Antioxidants in Star Fruit Using High Performance Liquid Chromatography and Mass Spectrometry. J. Chromatogr. A. 1022 (2004) 67-75.
    222.  Shui G, Leong LP. Separation and Determination of Organic Acids and Phenolic Compounds of Fruit Juices and Drinks by High Performance Liquid Chromatography. J. Chromatogr. A 977 (2002) 89-97
    223.  Leong LP, Shui G. An Investigation of Antioxidant Capacity of fruits in the Singapore markets. Food Chem. 76(2002) 69-75.

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