--中国科学院遗传与发育生物学研究所

姓　　名：	田烨
职　　称：	研究员
职　　务：	主任
电话/传真：
电子邮件：	ytianATgenetics.ac.cn
实验室主页：	http://tian_lab.genetics.ac.cn
研究方向：	线粒体应激信号与衰老调控

简历介绍：

田烨，博士，研究员，博士生导师

2010年获北京师范大学和北京生命科学研究所联合培养项目博士学位。2010-2016年先后在美国索尔克生物研究所和加州大学伯克利分校从事博士后研究。2016年加入中国科学院遗传与发育生物学研究所。先后获得科技部国家重点研发计划青年科学家项目、国家自然科学基金重点项目、国家杰出青年基金项目等资助。2021年入选细胞生物学杂志线粒体专刊人物专访，曾获得2019年国家自然科学奖二等奖（第三完成人）、2021年中源协和生命医学奖-创新突破奖、2022年中国科学院青年科学家奖、2023年顾孝诚讲座奖、2024年科学探索奖等。

研究领域：

线粒体不仅是细胞能量代谢的核心细胞器，也是感知环境变化、调控细胞命运和维持组织稳态的重要信号枢纽。线粒体功能受损后，细胞可启动线粒体未折叠蛋白反应（Mitochondrial unfolded protein response，UPR^mt）、整合应激反应、代谢重塑和细胞器质量控制等适应性机制，以恢复细胞稳态并增强机体抗逆能力。线粒体应激反应的强度、持续时间和发生阶段，决定其是促进修复与健康寿命，还是导致组织功能障碍和疾病发生。

本实验室聚焦线粒体应激信号、细胞与组织抗应激能力以及衰老调控机制，综合利用秀丽隐杆线虫、哺乳动物细胞和小鼠模型，从细胞器、细胞、组织和整体动物等不同层次，研究线粒体损伤如何被感知、传递和记忆，以及这些过程如何影响组织稳态、机体衰老和衰老相关疾病。

1. 线粒体应激感知与细胞稳态重塑

线粒体损伤可产生多种逆向信号，调控核基因表达、染色质状态、脂质代谢、钙信号以及其他细胞器的结构与功能。我们研究细胞如何识别不同类型的线粒体应激，并协调线粒体修复、细胞器互作、核膜完整性和细胞存活，揭示适应性应激与病理性损伤之间的分子界限。

2. 神经系统介导的跨组织应激通讯与系统性衰老

线粒体应激并不局限于受损细胞本身。神经系统能够感知局部线粒体功能变化，并通过神经递质、神经肽、生长因子及其他分泌信号，将应激信息传递至肠道、代谢组织和免疫系统，从而调控全身线粒体稳态、代谢状态、屏障功能和寿命。我们重点研究神经元线粒体应激如何重塑神经活动和细胞间通讯，并探索这些跨组织调控机制在衰老及衰老相关功能衰退中的保守性。

3. 应激记忆、表观遗传调控与衰老

生命早期经历的轻度线粒体应激可对成年期乃至整个生命周期产生持久影响，提示短暂的细胞器压力能够形成长期的分子记忆。我们研究线粒体应激如何调控染色质重塑、转录因子活性和表观遗传状态，并进一步影响后续应激反应、组织功能和寿命，阐明发育期环境和细胞器状态如何设定个体的衰老轨迹。

4. 宿主—微生物互作与个体化衰老

肠道微生物及其代谢产物能够影响宿主营养代谢、氧化还原平衡、免疫反应和屏障功能，但相同微生物在不同遗传背景宿主中可能产生截然不同的健康效应。我们利用线虫天然微生物资源和宿主遗传学方法，研究微生物来源的代谢物、脂质和细胞组分如何调控宿主线粒体功能、应激防御和寿命，并解析宿主遗传背景如何决定微生物干预的有益或有害效应，为精准化健康干预提供理论依据。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

(^#Co-first author; * Corresponding author)

1. Zhang Q^#, Dong HY^#, Jiang YY^#, Wang ZH, Li JS, Tian Y* (2026). FUBL-3/FUBP1 Mediates Mitochondrial Stress-induced Chromatin Remodeling and Longevity. Science Advances, 12(26):eaec8143.

2. Hao XS, Yuan RW, Guo YF, Chen GY, Guo YQ, Liu LM, Lu F, Bai Y, Tian Y* (2026). Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions. Aging Cell, 25(2):e70418.

3. Chen P^#, Zhang LY^#, Wu XY, Liang ZQ, Hao XS, Zhu QY, Liu Y, Zheng JR, Zhang Q, Yang QM, Zhou F, Zhou CB, Tian Y* (2026). Mitochondrial Superoxide Regulates Nuclear Envelope Integrity and Aging via Redox-mediated Lipid Metabolism. Nature Metabolism, 8(2):371-388.

4. Chen GY^#, Dong HY^#, Tian Y* (2026). Mito-nuclear Communication: From Cellular Responses to Organismal Health. Molecular Cell, 86(3):522-532.

5. Thaiss CA*, Tian Y*, Winer DA*, Linterman M*, Liston A*, Amor C*, Lowe SW*, Liu GH* (2025). Aging and Immunity. Immunity, 58(11):2609-2612.

6. Zhu HD, Zhang Q, Tian Y* and Cohen E* (2025). TGF-β Signaling as an Organismal Proteostasis Regulator. Trends in Cell Biology, 35(12):1016-1027.

7. Zhou J^#, Zhu D^#, Wang YB, Wang ZL, Zhang N, Huang XH, Zhang YQ, Wang YC, Wu XY* and Tian Y* (2025). Mitochondrial Stress Orchestrates Chromatin Remodeling and Longevity via Phosphoregulation of the NuRD Component LIN-40. SCIENCE CHINA Life Sciences, 68(11):3340-3352.

8. 张宁, 田烨* (2025). 基于荧光蛋白的生物探针设计策略及其应用[J]. 遗传, 47(7):711-728.

9. Li JS, Cui JM, Li XY, Zhu D, Chen ZH, Huang XH, Wang YC, Wu QF and Tian Y* (2025). TMBIM-2 Orchestrates Systemic Mitochondrial Stress Response via Facilitating Ca²⁺ Oscillations. Journal of Cell Biology, 224(5):e202408050.

10. Liu LM^#*, Hao XS^#, Bai Y* and Tian Y* (2025). The soil Mycobacterium sp. Promotes Health and Longevity through Different Bacteria-derived Molecules in Caenorhabditis elegans. Aging Cell, 24(3):e14416.

11. Wu JC^#, Liu Y^#, Ou LQ^#, Gan TT^#, Zhangding ZR, Yuan SP, Liu XY, Liu MZ, Li JS, Yin JH, Xin CC, Tian Y and Hu JZ* (2024). Transfer of Mitochondrial DNA into the Nuclear Genome during Induced DNA Breaks. Nature Communications, 15(1):9438.

12. Wang ZH^#, Zhang Q^#, Jiang YY, Zhou J and Tian Y* (2024). ASI-RIM Neuronal Axis Regulates Systemic Mitochondrial Stress Response via TGF-β Signaling Cascade. Nature Communications, 15(1):8997.

13. Chen P, Zhang LY, Chen D* and Tian Y* (2024). Mitochondrial Stress and Aging: Lessons from C. elegans. Seminars in Cell and Developmental Biology, 154(Pt A):69-76.

14. Ren J, Song MS, Zhang WQ, Cai JP, Cao F, Cao ZW, Chan P, Chen C, Chen GB, Chen HZ, Chen J, Chen XC, Ci WM, Ding BS, Ding QR, Gao F, Gao SR, Han JJ, He QY, Huang K, Ju ZY, Kong QP, Li J, Li J, Li JY, Li X, Liu BH, Liu F, Liu JP, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo XH, Ma S, Ma XR, Mao ZY, Nie J, Peng YJ, Qu J, Ren RB, Song WH, Songyang Z, Sun L, Sun YE, Sun Y, Tian M, Tian XL, Tian Y, Wang JW, Wang SS, Wang S, Wang WG, Wang X, Wang XN, Wang YJ, Wang YF, Wong CCL, Xiang AP, Xiao YC, Xiao ZX, Xie ZW, Xiong W, Xu DC, Yang Z, Ye J, Yu W, Yue R, Zhang CT, Zhang HB, Zhang L, Zhang XC, Zhang Y, Zhang YW, Zhang ZH, Zhao TB, Zhao YZ, Zhou ZJ, Zhu DH, Zou WG, Pei G and Liu GH (2023). The Aging Biomarker Consortium Represents a New Era for Aging Research in China. Nature Medicine, 29(9):2162-2165.

15. 张茜^#, 王子豪^#, 田烨* (2023). 跨组织线粒体应激信号交流调控机体衰老的研究进展[J]. 遗传, 45(3):187-197.

16. Zhang HL^#, Li XY^#, Fan WD, Pandovski S, Tian Y* and Dillin A* (2023). Inter-tissue Communication of Mitochondrial Stress and Metabolic Health. Life Metabolism, 2(1):1-11.

17. Li JS^#, Cui JM^# and Tian Y* (2022). Neuron-Periphery Mitochondrial Stress Communication in Aging and Diseases. Life Medicine, 1(2):168-178.

18. Liu YL^#, Zhou J^#, Zhang N, Wu XY, Zhang Q, Zhang WF, Li XY and Tian Y* (2022). Two Sensory Neurons Coordinate the Systemic Mitochondrial Stress Response via GPCR Signaling in C. elegans. Developmental Cell, 57(21):2469-2482.e5.

19. Cai YS^#, Song W^#, Li JM^#, Jing Y^#, Liang CQ^#, Zhang LY^#, Zhang X^#, Zhang WH^#, Liu BB^#, An YP^#, Li JY^#, Tang BX^#, Pei SY^#, Wu XY^#, Liu YX^#, Zhuang CL^#, Ying YL^#, Dou XF^#, Chen Y^#, Xiao FH^#, Li DF^#, Yang RC^#, Zhao Y^#, Wang Y^#, Wang LH^#, Li YJ^#, Ma S*, Wang S*, Song XY*, Ren J*, Zhang L*, Wang J*, Zhang WQ*, Xie ZW*, Qu J*, Wang JW*, Xiao YC*, Tian Y*, Wang GL*, Hu P*, Ye J*, Sun Y*, Mao ZY*, Kong QP*, Liu Q*, Zou QG*, Tian XL*, Xiao ZX*, Liu Y*, Liu JP*, Song MS*, Han JD* and Liu GH* (2022). The Landscape of Aging. Science China-Life Sciences, 65(12):2354-2454.

20. Li XY, Li JS, Zhu D, Zhang N, Hao XS, Zhang WF, Zhang Q, Liu YL, Wu XY and Tian Y* (2022). Protein Disulfide Isomerase PDI-6 Assists Wnt Secretion to Coordinate Inter-tissue UPR^mt and Lifespan Extension in C. elegans. Cell Reports, 39(10):110931.

21. Zhu D^#, Li XY^# and Tian Y* (2022). Mitochondrial-to-nuclear Communication in Aging: An Epigenetic Perspective. Trends in Biochemical Sciences, 47(8):645-659.

22. Zhang Q and Tian Y* (2022). Molecular Insights into the Transgenerational Inheritance of Stress Memory. Journal of Genetics and Genomics, 49(2):89-95.

23. Zhang Q, Wang ZH, Zhang WF, Wen QB, Li XY, Zhou J, Wu XY, Guo YQ, Liu YL, Wei CS, Qian WF and Tian Y* (2021). The Memory of Neuronal Mitochondrial Stress is Inherited Transgenerationally via Elevated mtDNA Levels. Nature Cell Biology, 23(8):870-880.

24. Wang YL^#, He KX^#, Sheng BF^#, Lei XQ, Tao WY, Zhu XL, Wei Z, Fu RJ, Wang AL, Bai SD, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li MS, Zhang KG, Li L, Yang H*, Li HB*, Flavell RA* and Zhu S* (2021). The RNA Helicase Dhx15 Mediates Wnt-Induced Antimicrobial Protein Expression in Paneth Cells. PNAS, 118(4):e2017432118.

25. Rong BW^#, Zhang Q^#, Wan JK, Xing SH, Dai RF, Li Y, Cai JB, Xie JY, Song Y, Chen JW, Zhang L, Yan GQ, Zhang W, Gao H, Han JD, Qu QH, Ma HH*, Tian Y* and Lan F* (2020). Ribosome 18S m⁶A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth. Cell Reports, 33(12):108544.

26. Zhu D^#, Wu XY^#, Zhou J, Li XY, Huang XH, Li JS, Wu JB, Bian Q, Wang YC and Tian Y* (2020). NuRD Mediates Mitochondrial Stress-Induced Longevity via Chromatin Remodeling in Response to Acetyl-CoA Level. Science Advances, 6(31):eabb2529.

27. Zhang Q^#, Wu XY^#, Chen P^#, Liu LM, Xin N, Tian Y* and Dillin A* (2018). The Mitochondrial Unfolded Protein Response is Mediated Cell-non-Autonomously by Retromer-Dependent Wnt Signaling. Cell, 174(4):870-883.e17.

28. Tian Y, Garcia G, Bian Q, Steffen KK, Joe L, Wolff S, Meyer BJ and Dillin A* (2016). Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR^mt. Cell, 165(5):1197-1208.

29. Tian Y^#, Merkwirth C^# and Dillin A* (2016). Mitochondrial UPR: A Double-Edged Sword. Trends in Cell Biology, 26(8):563-565.

30. Berendzen KM^#, Durieux J^#, Shao LW, Tian Y, Kim H, Wolff S, Liu Y and Dillin A* (2016). Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis. Cell, 166(6):1553-1563.e10.

31. Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A and Guan KL* (2013). ULK1 Induces Autophagy by Phosphorylating Beclin-1 and Activating VPS34 Lipid Kinase. Nature Cell Biology, 15(7):741-750.

32. Tian Y^#, Li Z^#, Hu W^#, Ren H^#, Tian E, Zhao Y, Lu Q, Huang X, Yang P, Li X, Wang X, Kovacs A, Yu L* and Zhang H* (2010a). C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell, 141(6):1042-1055.

33. Tian Y, Ren HY, Zhao Y, Lu Q, Huang XX, Yang PG and Zhang H* (2010b). Four Metazoan Autophagy Genes Regulate Cargo Recognition, Autophagosome Formation and Autolysosomal Degradation. Autophagy, 6(7):984-985.