--中国科学院遗传与发育生物学研究所

姓　　名：	李红菊
职　　称：	研究员
职　　务：
电话/传真：	010-64806901
电子邮件：	hjli@genetics.ac.cn
实验室主页：
研究方向：	植物发育生物学

简历介绍：

李红菊，博士，研究员，博导,课题组组长

2004年获河北师范大学学士学位，2010年获中科院遗传发育所博士学位。2010/3-2016/12年，在遗传发育所任助理研究员和副研究员。2017/1-至今，研究员，2017/9-2017/12德国Münster大学访问学者。2013年获国家自然科学二等奖（第五排名），2016年获国家自然科学基金委“优秀青年基金”资助，2018年入选中科院青年创新促进会优秀会员。任Seed Biology编委、中国植物学会理事、植物结构与生殖生物学专业委员会主任。

研究领域：

研究领域：
研究方向为植物有性生殖发育，重点关注传粉受精及种子发育启动的分子调控机理，探索通过大豆远缘杂交和从头驯化改良和创制新型作物。

研究内容：

1.植物传粉受精的分子机制和演化

开花植物有性生殖过程涉及花序和花发育，传粉受精和种子发育和成熟等过程。每个过程都受到精细的分子调控，并且与作物杂交育种和产量形成密切相关。课题组以拟南芥和豆科植物为材料，重点解析花序和花发育、传粉受精和种子发育的分子机理，探究关键基因在单双子叶植物生殖效率和杂交育种中的应用，探索远缘杂交技术策略，以实现不同物种间的优良基因重组，创制新物种和新种质资源、以拓展杂种优势利用范围，服务农业生产。

2. 植物双受精和种子发育的遗传调控和演化

被子植物双受精启动种子发育，这一过程受复杂的分子机制调控。课题组通过多种手段，解析种子发育的分子调控机理，建立种子改良、单倍体诱导和无融合生殖技术体系，服务农业杂交育种和制种需求。

近期招聘信息：

本课题组目前招收博士后（受精恢复机制、种子发育、豆科植物发育特征改造和驯化）、客座研究生、科研助理。欢迎对植物发育与驯化感兴趣的有志青年申请。（hjli@genetics.ac.cn）

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

(*Co-first author; #Co-corresponding author)

1. Wang WQ*, Meng JG*, Yang F, Xu YJ, Li, SZ, and Li HJ. (2024). A non-defensin peptide NPA1 attracts pollen tube in Arabidopsis. Seed Biology 3: e003.

2. Meng JG*, Xu YJ*, Wang WQ*, Yang F*, Chen SY, Jia PF, Yang WC, and Li HJ (2023) Central cell-produced attractants control fertilization recovery. Cell 186:1-13.

3. Wang J, Wang XF, Yang WC*, and Li HJ* (2023) Loss of function of CENH3 causes genome instability in soybean. Seed Biology 2: 24.

4. Li S, Wang J, Jia S, Wang K* and Li HJ* (2023) Synthetic apomixis: from genetic basis to agricultural application. Seed Biology 2: 10.

5. Chen SY, Wang L, Jia PF, Yang WC, Sze H, and Li HJ (2022) Osmoregulation determines sperm cell geometry and integrity for double fertilization in flowering plants. Mol Plant 15: 1488–1496.

6. Xue Y*, Meng JG*, Jia PF, Zhang ZR, Li HJ# and Yang WC# (2022) POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis. Nat Commun 13: 2703.

7. Xue Y, Jia PF, Li HJ (2022) SUN3/4/5 proteins regulate endoplasmic reticulum tubule formation and luminal spacing in Arabidopsis. J Genet Genomics 50: 370-373.

8. Luo Y, Shi DQ, Jia, PF, Bao Y, Li HJ, Yang WC (2021) Nucleolar histone deacetylases HDT1, HDT2 and HDT3 regulate plant reproductive development. J Genet Genomics 49:30-39.

9. Li HJ#, Yang WC# (2020) Central cell in flowering plants: specification, signaling, and evolution. Front Plant Sci 11: 590307.

10. Chen W, Jia PF, Yang WC#, Li HJ# (2020) Plasma membrane H⁺-ATPases-mediated cytosolic proton gradient regulates pollen tube growth. J Integr Plant Biol 62: 1817-1822.

11. Zhang MX#, Zhu SS#, YC, Guo YL, Yang WC#, Li HJ# (2020) Transcriptional repression specifies the central cell for double fertilization. Proc Natl Acad Sci U S A117: 6231-6236.

12. Meng JG#, Liang L#, Jia PF, Wang YC, Li HJ#, Yang WC# (2020) Integration of ovular signals and exocytosis of a Ca²⁺ channel by MLOs in pollen tube guidance. Nat Plants 6: 143-153.

13. Meng JG, Zhang MX, Yang WC#, Li HJ# (2019) TICKET attracts pollen tubes and mediates reproductive isolation between relative species in Brassicaceae. Sci China Life Sci 62: 1413-1419.

14. Shi C, Luo P, Du YT, Chen H, Huang X, Cheng TH, Luo A, Li HJ, Yang WC, Zhao P, Sun MX (2019) Maternal control of suspensor programmed cell death via gibberellin signaling. Nat Commun 10: 3484.

15. Jia PF*, Xue Y*, Li HJ#, Yang WC# (2018) Golgi-localized LOT regulates trans-Golgi network biogenesis and pollen tube growth. Proc Natl Acad Sci U S A 115: 12307-12312.

16. Li HJ#, Meng JG, Yang WC# (2018) Multilayered signaling pathways for pollen tube growth and guidance. Plant Reprod 31: 31-41.

17. Li HJ#, Yang WC# (2018) Ligands switch model for pollen-tube integrity and burst. Trends Plant Sci 23: 369-372.

18. Yuan GL, Li HJ#, Yang WC# (2017) The integration of Gβ and MAPK signaling cascade in zygote development. Sci Rep 7: 8732.

19. Jia PF, Li HJ, Yang WC (2017) Analysis of peroxisome biogenesis in pollen by confocal microscopy and transmission electron microscopy. Methods Mol Biol 1669:173-180. Springer.

20. Jia PF, Li HJ, Yang WC (2017) Transmission electron microscopy (TEM) to study histology of pollen and pollen tubes. Methods Mol Biol 1669:181-189. Springer.

21. Wang T, Liang L, Yong X, Jia PF, Chen W, Zhang MX, Wang YC, Li HJ#, Yang WC# (2016) A receptor heteromer mediates the male perception of female attractants in plants. Nature 531: 241-244.

22. Li HJ#, Yang WC# (2016) RLKs orchestrate the signaling in plant male-female interaction. Sci China Life Sci 59: 867-877.

23. Wang JG, Feng C, Liu HH, Ge FR, Li S, Li HJ, Zhang Y (2016) HAPLESS13-mediated trafficking of STRUBBELIG is critical for ovule development in Arabidopsis. PLoS Genetics 12: e1006269.

24. Yu TY, Shi DQ, Jia PF, Tang J, Li HJ, Liu J, Yang WC (2016). The Arabidopsis receptor kinase ZAR1 is required for zygote asymmetric division and its daughter cell fate. PLoS Genetics 12: 0-e1005933.

25. Wang J*, Li HJ*, Han Z, Zhang H, Wang T, Lin G, Chang J, Yang WC#, Chai J# (2015) Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525: 265-268.

26. Li HJ*, Zhu SS*, Zhang MX*, Wang T, Liang L, Xue Y, Shi DQ, Liu J, Yang WC (2015) Arabidopsis CBP1 is a novel regulator of transcription initiation in central cell-mediated pollen tube guidance. Plant Cell 27: 2880-2893.

27. Yan L, Wei S, Wu Y, Hu R, Li HJ, Yang W, Qi Xie (2015) High efficiency genome editing in Arabidopsis using Yao promoter-driven CRISPR/Cas9 system. Mol Plant 1823: 1820-1823.

28. Li XR*, Li HJ*, Yuan L*, Liu M, Shi DQ, Liu J, Yang WC (2014) Arabidopsis DAYU/ABERRANT PEROXISOME MORPHOLOGY9 is a key regulator of peroxisome biogenesis and plays critical roles during pollen maturation and germination in planta. Plant Cell 26: 619-635.

29. Li HJ, Yang WC (2012) Emerging role of ER quality control in plant cell signal perception. Protein Cell 3: 10-16.

30. Li HJ, Xue Y, Jia DJ, Wang T, Shi DQ, Liu J, Cui F, Xie Q, Ye D, Yang WC (2011) POD1 regulates pollen tube guidance in response to micropylar female signaling and acts in early embryo patterning in Arabidopsis. Plant Cell 23: 3288-3302.

31. Li HJ*, Liu NY*, Shi DQ, Liu J, Yang WC (2010) YAO is a nucleolar WD40-repeat protein critical for embryogenesis and gametogenesis in Arabidopsis. BMC Plant Biol 10: 169.

32. Chen YH, Li HJ, Shi DQ, Yuan L, Liu J, Sreenivasan R, Baskar R, Grossniklaus U, Yang WC (2007) The central cell plays a critical role in pollen tube guidance in Arabidopsis. Plant Cell 19: 3563-3577.