姓  名: 段力辉
    职  称: 研究员
    职  务:
    电话/传真: 86-10-64806596
    电子邮件: lihui.duan@genetics.ac.cn
    实验室主页:
    研究方向: 神经免疫互作与工程(Neuro-Immune Crosstalk & Engineering Lab)

    简历介绍:

    段力辉,博士,研究员,博士生导师
        2010年在华中农业大学生物学基地班获得理学学士学位;2018年在中国科学院神经所获得博士学位;2018年至2022年在加州大学旧金山分校从事博士后研究工作;2022年加入中国科学院遗传与发育生物学研究所任研究员。

    研究领域:

    主要研究内容:
        1)   前沿组学技术开发;
        2)   神经系统衰老与疾病;
        3)   脑膜的结构与功能。

    社会任职:

    获奖及荣誉:

    承担科研项目情况:

    代表论著:


    Li, X., Huang, Y., Wang, S., Li, Y. et al. (2025). OpenFISH eables integrated high-resolution spatial transcriptomics  and metabolomics on a single tissue section. bioRxiv
    Ye D, Feng S, Yang X, et al. Hedgehog-interacting protein orchestrates alveologenesis and protects against bronchopulmonary dysplasia and emphysema. Sci Adv 11(19) (2025) eadu2958.
    Li YZ, Gao L, Sun X-L, et al. Neural cell competition sculpting brain from cradle to grave. National Science Review 12(5) (2025).
    Ben-Shaanan TL, Knöpper K, Duan L, et al. Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice. Developmental Cell  (2024).
    Duan L,Yu X Fibroblasts: New players in the central nervous system? Fundamental Research  (2023).
    Wolf EW, Howard ZP, Duan L, et al. GPR174 signals via Galphas to control a CD86-containing gene expression program in B cells. Proc Natl Acad Sci U S A 119(23) (2022) e2201794119.
    Liu, D., Duan, L., Rodda, L., Lu, E., Xu, Y., An, J., Qiu, L., Liu, F., Looney, M., Yang, Z., Allen, C., Li, Z., Marson, A., Cyster, J.G. CD97 promotes spleen dendritic cell homeostasis through mechanosensing of red blood cells. Science
    Liu, D., Duan, L., Cyster, J.G. Chemo- and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen. Immunological Reviews.
    Duan, L.*, Liu, D.*, Chen, H., Mintz, M.A., Chou, M.Y., Kotov, D.I., Xu, Y., An, J., Laidlaw, B.J., and Cyster, J.G. (2021). Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation. Immunity 2021 Sep 18; 10.1016/j.immuni.2021.08.028. (Highlighted by Nature Immunology)
    Laidlaw, B.J., Duan, L., Xu, Y., Vazquez, S.E., and Cyster, J.G. (2020). The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nat Immunol 21, 1082-1093.
    Duan, L.*, Zhang, X.*, Miao, W., Sun, Y., Xiong, G., Wu, Q., Li, G., Yang, P., Yu, H., Li, H., Wang, Y., Zhang, M., Hu, L., Tong, X., Zhou, W., Yu, X. (2018). PDGFRbeta Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2. Neuron 100, 183-200 e188. (Preview highlight on Neuron)
    Zhang, S.*, Duan, L.*, He, S., Zhuang, G. & Yu, X. (2017). Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation. Cell Research 27, 253-273, doi:10.1038/cr.2017.13.
    Zhang, S.*, Duan, L.*, Qian, H. & Yu, X. (2016). Actin Aggregations Mark the Sites of Neurite Initiation. Neuroscience Bulletin 32, 1-15, doi:10.1007/s12264-016-0012-2.
    翻译书籍:
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