--中国科学院遗传与发育生物学研究所

姓　　名：	武照伐
职　　称：	研究员
职　　务：
电话/传真：	86-10-64801204
电子邮件：	wuzhaofa@genetics.ac.cn
实验室主页：
研究方向：	神经通讯与脑功能

简历介绍：

武照伐，博士，研究员，博士生导师

2013年获西北农林科技大学学士学位；2019年获北京大学博士学位（导师：李毓龙教授）；2019-2023年获勃林格殷格翰博士后基金、CLS杰出博士后基金，在北京大学从事博士后研究（合作导师：李毓龙教授和‪Bastian Hengerer教授）；‬2023年10月加入中国科学院遗传与发育生物学研究所。获国家自然科学青年科学基金B类（原优青）、中国科学院稳定支持基础研究领域青年团队等项目支持。入选北京市青年人才托举工程、中国科学院大学小米青年学者，获朝阳区凤凰计划高层次人才认定。‬‬‬‬‬‬‬

研究领域：

研究方向介绍：

大脑是已知最复杂的器官，近860亿个神经元编织成浩瀚网络，每个神经元可形成上万个连接点；它也是最奢侈的耗能者，仅占体重2%，却消耗全身20%的能量。如此庞大的通讯系统，如何为瞬息万变的神经活动和递质释放精准供能，是神经科学的一个核心谜题。围绕这一谜题，我们融合荧光探针开发、活体成像、光遗传学/基因编辑操控和化学生物学等跨学科手段，解析脑细胞间的通讯逻辑与代谢基础。具体从三个层面展开：

1)神经代谢分子的动态检测与功能解码：发展高时空分辨的荧光探针，实时追踪核苷、脂类等关键代谢分子，揭示它们在睡眠、情绪等生理过程及癫痫、中风等病理状态下的动态规律与功能。

2）细胞类型特异的能量代谢机制：探究神经元、胶质细胞等不同脑细胞如何协同调控能量的生产、分配与利用，以响应神经网络时刻变化的能量需求。

3）神经-肿瘤-免疫通讯：挖掘神经系统与肿瘤、免疫系统之间的双向对话，重点解析代谢信号在其中的介导作用与调控机制。

课题组现开放：副/助理研究员、博士后（特别研究助理）、硕博/直博生（暂不招收仅硕士计划）。如果你对脑科学充满好奇，渴望用新技术破解生命最复杂的谜题，别犹豫，请发邮件至：wuzhaofa@genetics.ac.cn。欢迎加入我们，一起“脑”洞大开！

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

代表性论文（*Corresponding author; #Co-first author）：

1. Wei, Q.# Bai, Z.#, Wang, L.#, ... Li, Y.*, Wu, Z.*, & Wang, J.* (2025). A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo. Nature Communications, 16(1), 1-18.

2. Li, YM., Zhang, L., Li, B., Li, YL. & Wu, Z.* (2025). State of the art indicators for imaging purinergic dynamics in vitro and in vivo. Purinergic Signalling, 21(4), 945-957.

3. Yahiro, T., ..., Cragg, S.*, Lopes, L.*, Wu Z.*, Chen, J.* & Zhong, H*. (2025). Adenosine in the Brain: Recent Progress on Detection, Function, and Translation. Journal of Neuroscience, 45(46).

4. Zhou, X.#, He, Y.#, Xu, T.#, Wu, Z.#, Guo, W., Xu, X., ... & Chen, J.* (2024). 40 Hz light flickering promotes sleep through cortical adenosine signaling. Cell Research, 1-18.

5. Wu, Z.#, Cui, Y.#, Wang, H.#, …, Xu, M., Luo, M.* & Li, Y.* (2023), Neuronal activity-induced, ENT-dependent, somatodendritic adenosine release revealed by a GRAB sensor. PNAS, 120(14), e2212387120.

6. Wu, Z.*, He, K., Chen, Y., …, Du, J., Jing, M., & Li, Y.* (2022). A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. Neuron, 110, 770-782 e775. —Selected as the “Best of Neuron 2021-2022”.

7. Peng, W.#, Wu, Z.#, Song, K.#, Zhang, S., Li, Y. & Min, X.* (2020). Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons. Science, 369, 1208.

8. Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics.

9. Wu, Z., Lin, D., & Li, Y.* (2022), Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. Nature Reviews Neuroscience, 23, 257–274.

10. Wu, Z.*, & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, 35-43. (Cover).

其它论文：

11. Zhang, Q.#, Lin, H.#, Yuan, J.#, Zhang, S. P.#, ..., Wu, Z., ... & Yan, B.* (2026). Discovery of 2-Chloro-pyrrolo [2, 3-d] pyrimidin-4-one Derivatives as Protein Disulfide Isomerase Inhibitors with a Novel Allosteric-Covalent Binding Mode and Anti-Glioblastoma Activity. Journal of Medicinal Chemistry.

12. Wu, D.#, Wu, J.#, Chen, H.#, Luo, R.#, ... Wu, Z., ...Chen, Y.* & Gao, T.* (2026). ATP release from the amygdala-prefrontal pathway regulates vulnerability to social stress in male mice. Molecular Psychiatry, 1-17.

13. Chen, B.#, Guo, H.#, …, Wu, Z., Chen, Y.* & Qin, W.* (2026). In vivo-compatible spatial multi-omics via hydrogen peroxide-independent APEX2 labeling. bioRxiv, 2026-03.

14. Yue, C.#, Wang, N.#, ..., Wu, Z. ..., Wang, X.* & Luo, M.* (2026). Adenosine signalling drives antidepressant actions of ketamine and ECT. Nature, 649(8096), 423-431.

15. Xin, Q.#, Wang, J.#, ..., Wu, Z, ..., Hu, H.* (2025). Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors. Cell, 188(12), 3291-3309.

16. Park, G.#, Lee, G.#, …, Wu, Z., Li, Y., & Choi M.* (2025). Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation. Cell, 188, 141-156 e16

17. Wang, W.#, Guo, H.#, Yan, X.# …, Wu, Z., Qin, W.*, & Chu, L.* (2025). Silicon-rhodamine-enabled identification for near-infrared light controlled proximity labeling in vitro and in vivo. Nature Communications, 16(1), 8134.

18. Zhang, Z.#, Wang, Y.#, ... Wu, Z., & Qin, W.* (2025). Spatiotemporally-resolved mapping of extracellular proteomes via in vivo-compatible TyroID. Nature Communications, 16, 2553

19. Liu, X., Huang, H., … Wu, Z., ... & Wang, F.* (2025). A neural circuit for female-specific defensive homeostasis in risk assessment. bioRxiv, 2025-09.

20. Li, H., Zhao, Y., …, Wu, Z., Li, Y., & Luo, M.* (2024). Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis. Molecular Psychiatry, 1-15.

21. Umpierre, A. D.#, Li, B.#, …, Wu, Z., ... & Wu, L.* (2024). Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis. Neuron, 112(12), 1959-1977.

22. Chen, Y.#, Luan, P.#, Liu, J.#, …, Wu, Z., & Jing, M.* (2024). Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice. Nature Neuroscience, 1-12.

23. Berki, P.#, Cserép, C.#, Környei, Z.#, …, Wu, Z., ... & Dénes, Á.* (2024). Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices. Nature Communications, 15(1), 5402.

24. Roy, K.#, Zhou, X.#, Otani, R.#, Yuan, P. C.#, …, Wu, Z., ... & Lazarus, M.* (2024). Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors. Nature Communications, 15(1), 3661.

25. Bayazitov, I. T., Teubner, B. J., Feng, F., Wu, Z., Li, Y., Blundon, J. A., & Zakharenko, S.* (2024). Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning. Cell Reports, 43(2).

26. Ji, E., Zhang, Y., Li, Z., Wei, L., Wu, Z., Li, Y., Yu, X.*, & Song, TJ.* (2024). The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking. Neuroscience Bulletin, 1-18.

27. Guo, Q. #, Hou, T.#, Xie, W.#, ... Wu, Z., … & Wang, S.* (2024). Calcium Homeostasis Modulator 2 Constitutes an ATP-regulation Pore in Mitochondria. bioRxiv, 2024-09.

28. Peng, W.#*, Liu, X.#, Ma, G.#, Wu, Z., … Zhang, S.*, & Min, X.* (2023). Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity. Cell Discovery, 9(1), 16.

29. Li, X., Li, Y., Zhou, Y., …, Wu, Z., ... & Dai, Q.* (2023). Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit. Nature Biotechnology, 41, 282–292.

30. Hatashita, Y., Wu, Z., …, & Inoue, T.* (2023). Spontaneous and multifaceted ATP release from astrocytes at the scale of hundreds of synapses. Glia, 71(9), 2250-2265.

31. Lin, R.#*, Zhou, Y.#, Yan, T.#, Wang, R.#, Li, H., Wu, Z., ... & Luo, M.* (2022). Directed evolution of adeno-associated virus for efficient gene delivery to microglia. Nature Methods, 1-10.

32. Pittolo, S., Yokoyama, S., Willoughby, D., ... Wu, Z., … & Poskanzer, K.* (2022). Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors. Cell Reports, 40.

33. Roberts, B., Lambert, E., Livesey, J., Wu, Z., Li, Y. & Cragg, S.* (2022). Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol. The Journal of Neuroscience, 42, 1738-1751.

34. Lu, C.#, Ren, J.#, Mo J., …, Wu, Z., Li, Y., Gao, T., Cao, X.* (2022). Glucocorticoid receptor-dependent astrocytes mediate stress vulnerability. Biological Psychiatry, 92(3), 204-215.

35. Dai, R., Yu, T., Weng, D., Li, H., Cui, Y., Wu, Z., ... & Luo, M.* (2022). A neuropsin-based optogenetic tool for precise control of Gq signaling. Sci. China Life Sci., 1-14.

36. Qian, C., Wu, Z.#, Sun, R.#, …, & Li, Y.* (2021). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. eLife, 10, e65417.

37. Wang, Q.#, Kong, Y.#, Wu, D. Y., ..., Wu, Z., Li, Y., Yang, J.*, & Gao, T.* (2021). Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice. Nature Communications, 12(1), 1-13.

38. Feng, J., Zhang, C., Lischinsky, J. E., …, Wu, Z., ... Lin, D., Du, J., & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761.

39. Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., …, Lei, X., Luo, W.* & Li, Y.* (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431.